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Murcko scaffold

Ring system with 3 rings and 23 atoms

86 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
86
With full pages
5
Scaffold SMILES

O=C(NCCN1CCN(c2ccccc2)CC1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCCN1CCN(c2ccccc2)CC1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 86 chemicals

Benzamide, 4-amino-2,6-dimethyl-N-(2-(4-phenyl-1-piperazinyl)ethyl)- chemical structure, C21H28N4O, CAS 39728-52-4
Benzamide, 4-amino-2,6-dimethyl-N-(2-(4-phenyl-1-piperazinyl)ethyl)-
CAS 39728-52-4C21H28N4O
Benzamide, 4-amino-N-(2-(4-phenyl-1-piperazinyl)ethyl)- chemical structure, C19H24N4O, CAS 54998-45-7
Benzamide, 4-amino-N-(2-(4-phenyl-1-piperazinyl)ethyl)-
CAS 54998-45-7C19H24N4O
Benzamide, 2-methoxy-5-(methylsulfonyl)-N-(2-(4-(alpha,alpha,alpha-trifluoro-m-tolyl)-1-piperazinyl)ethyl)- chemical structure, C22H26F3N3O4S, CAS 82608-06-8
Benzamide, 2-methoxy-5-(methylsulfonyl)-N-(2-(4-(alpha,alpha,alpha-trifluoro-m-tolyl)-1-piperazinyl)ethyl)-
CAS 82608-06-8C22H26F3N3O4S
Benzamide, 2-methoxy-5-sulfamoyl-N-(2-(4-(alpha,alpha,alpha-trifluoro-m-tolyl)-1-piperazinyl)ethyl)- chemical structure, C21H25F3N4O4S, CAS 82608-07-9
Benzamide, 2-methoxy-5-sulfamoyl-N-(2-(4-(alpha,alpha,alpha-trifluoro-m-tolyl)-1-piperazinyl)ethyl)-
CAS 82608-07-9C21H25F3N4O4S
3-Methyl-N-[2-(4-phenylpiperazin-1-yl)ethyl]benzamide chemical structure, C20H25N3O, CAS 185299-21-2
3-Methyl-N-[2-(4-phenylpiperazin-1-yl)ethyl]benzamide
CAS 185299-21-2C20H25N3O
3-Methoxy-N-[2-(4-phenylpiperazin-1-yl)ethyl]benzamide chemical structure, C20H25N3O2, CAS 313231-63-9
3-Methoxy-N-[2-(4-phenylpiperazin-1-yl)ethyl]benzamide
CAS 313231-63-9C20H25N3O2
3-Chloro-N-[2-(4-phenylpiperazin-1-yl)ethyl]benzamide chemical structure, C19H22ClN3O, CAS 313231-70-8
3-Chloro-N-[2-(4-phenylpiperazin-1-yl)ethyl]benzamide
CAS 313231-70-8C19H22ClN3O
N-(2-(4-(4-Chlorophenyl)piperazin-1-yl)ethyl)-3-methoxybenzamide chemical structure, C20H24ClN3O2, CAS 219125-63-0
N-(2-(4-(4-Chlorophenyl)piperazin-1-yl)ethyl)-3-methoxybenzamide
CAS 219125-63-0C20H24ClN3O2
Benzamide, 3-chloro-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]- chemical structure, C20H24ClN3O2, CAS 91616-73-8
Benzamide, 3-chloro-N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-
CAS 91616-73-8C20H24ClN3O2
3-Methoxy-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}benzamide chemical structure, C21H27N3O3, CAS 192132-97-1
3-Methoxy-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}benzamide
CAS 192132-97-1C21H27N3O3
2-Methoxy-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]benzamide chemical structure, C21H27N3O3, CAS 219125-67-4
2-Methoxy-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]benzamide
CAS 219125-67-4C21H27N3O3
3-Methoxy-N-(2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)benzamide chemical structure, C21H27N3O3, CAS 772334-88-0
3-Methoxy-N-(2-(4-(4-methoxyphenyl)piperazin-1-yl)ethyl)benzamide
CAS 772334-88-0C21H27N3O3
N-{2-[4-(4-Fluorophenyl)piperazin-1-yl]ethyl}-3-methoxybenzamide chemical structure, C20H24FN3O2, CAS 486393-08-2
N-{2-[4-(4-Fluorophenyl)piperazin-1-yl]ethyl}-3-methoxybenzamide
CAS 486393-08-2C20H24FN3O2
Benzamide, N-[2-[4-(4-chlorophenyl)-1-piperazinyl]ethyl]-3-hydroxy- chemical structure, C19H22ClN3O2, CAS 351459-64-8
Benzamide, N-[2-[4-(4-chlorophenyl)-1-piperazinyl]ethyl]-3-hydroxy-
CAS 351459-64-8C19H22ClN3O2
2-Amino-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}benzamide chemical structure, C20H26N4O2, CAS 88068-66-0
2-Amino-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}benzamide
CAS 88068-66-0C20H26N4O2
N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}benzamide chemical structure, C20H25N3O2, CAS 91616-69-2
N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}benzamide
CAS 91616-69-2C20H25N3O2
2-Chloro-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}benzamide chemical structure, C20H24ClN3O2, CAS 91616-71-6
2-Chloro-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}benzamide
CAS 91616-71-6C20H24ClN3O2
4-Fluoro-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)benzamide chemical structure, C20H24FN3O2, CAS 27227-14-1
4-Fluoro-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)benzamide
CAS 27227-14-1C20H24FN3O2
2,6-Difluoro-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}benzamide chemical structure, C20H23F2N3O2, CAS 91617-21-9
2,6-Difluoro-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}benzamide
CAS 91617-21-9C20H23F2N3O2
2,3-Dimethoxy-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}benzamide chemical structure, C22H29N3O4, CAS 91616-88-5
2,3-Dimethoxy-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}benzamide
CAS 91616-88-5C22H29N3O4
4-Methoxy-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)benzamide chemical structure, C21H27N3O3, CAS 91616-90-9
4-Methoxy-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)benzamide
CAS 91616-90-9C21H27N3O3
3,4,5-Trimethoxy-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}benzamide chemical structure, C23H31N3O5, CAS 91616-91-0
3,4,5-Trimethoxy-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}benzamide
CAS 91616-91-0C23H31N3O5
Methyl 4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)carbamoyl)benzoate chemical structure, C22H27N3O4, CAS 700797-69-9
Methyl 4-((2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)carbamoyl)benzoate
CAS 700797-69-9C22H27N3O4
2-Hydroxy-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}benzamide chemical structure, C20H25N3O3, CAS 91617-13-9
2-Hydroxy-N-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}benzamide
CAS 91617-13-9C20H25N3O3