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Murcko scaffold

Ring system with 3 rings and 22 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
12
With full pages
7
Scaffold SMILES

O=C(CSc1nnc(Cc2ccccc2)o1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnc(Cc2ccccc2)o1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

2-(5-Benzyl-[1,3,4]oxadiazol-2-ylsulfanyl)-1-(4-methoxy-phenyl)-ethanone chemical structure, C18H16N2O3S, CAS 321981-05-9
2-(5-Benzyl-[1,3,4]oxadiazol-2-ylsulfanyl)-1-(4-methoxy-phenyl)-ethanone
CAS 321981-05-9C18H16N2O3S
2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(4-chlorophenyl)ethanone chemical structure, C17H13ClN2O2S, CAS 303226-51-9
2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(4-chlorophenyl)ethanone
CAS 303226-51-9C17H13ClN2O2S
2-{[5-(4-Methoxybenzyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-1-(4-methoxyphenyl)ethanone chemical structure, C19H18N2O4S, CAS 460364-48-1
2-{[5-(4-Methoxybenzyl)-1,3,4-oxadiazol-2-yl]sulfanyl}-1-(4-methoxyphenyl)ethanone
CAS 460364-48-1C19H18N2O4S
2-((5-Benzyl-1,3,4-oxadiazol-2-yl)thio)-1-(4-((difluoromethyl)thio)phenyl)ethanone chemical structure, C18H14F2N2O2S2, CAS 302552-45-0
2-((5-Benzyl-1,3,4-oxadiazol-2-yl)thio)-1-(4-((difluoromethyl)thio)phenyl)ethanone
CAS 302552-45-0C18H14F2N2O2S2
2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(4-nitrophenyl)ethanone chemical structure, C17H13N3O4S, CAS 825596-42-7
2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(4-nitrophenyl)ethanone
CAS 825596-42-7C17H13N3O4S
N-[4-[2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]phenyl]acetamide chemical structure, C19H17N3O3S, CAS 713106-61-7
N-[4-[2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]phenyl]acetamide
CAS 713106-61-7C19H17N3O3S
2-((5-Benzyl-1,3,4-oxadiazol-2-yl)thio)-1-(4-bromophenyl)ethanone chemical structure, C17H13BrN2O2S, CAS 326004-27-7
2-((5-Benzyl-1,3,4-oxadiazol-2-yl)thio)-1-(4-bromophenyl)ethanone
CAS 326004-27-7C17H13BrN2O2S
1-(4-Chlorophenyl)-2-[[5-[(4-ethoxyphenyl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone chemical structure, C19H17ClN2O3S, CAS 325853-75-6
1-(4-Chlorophenyl)-2-[[5-[(4-ethoxyphenyl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
CAS 325853-75-6C19H17ClN2O3S
2-((5-Benzyl-1,3,4-oxadiazol-2-yl)thio)-1-(3-nitrophenyl)ethanone chemical structure, C17H13N3O4S, CAS 303227-88-5
2-((5-Benzyl-1,3,4-oxadiazol-2-yl)thio)-1-(3-nitrophenyl)ethanone
CAS 303227-88-5C17H13N3O4S
2-((5-(4-Ethoxybenzyl)-1,3,4-oxadiazol-2-yl)thio)-1-(4-methoxyphenyl)ethanone chemical structure, C20H20N2O4S, CAS 325853-73-4
2-((5-(4-Ethoxybenzyl)-1,3,4-oxadiazol-2-yl)thio)-1-(4-methoxyphenyl)ethanone
CAS 325853-73-4C20H20N2O4S
2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(4-fluorophenyl)ethanone chemical structure, C17H13FN2O2S, CAS 303227-84-1
2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(4-fluorophenyl)ethanone
CAS 303227-84-1C17H13FN2O2S
2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(4-methylphenyl)ethanone chemical structure, C18H16N2O2S, CAS 886512-16-9
2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(4-methylphenyl)ethanone
CAS 886512-16-9C18H16N2O2S