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Murcko scaffold

Ring system with 3 rings and 22 atoms

49 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
22
Chemicals
49
With full pages
17
Scaffold SMILES

O=C(Nc1ccccc1)Nc1nnc(Cc2ccccc2)s1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)Nc1nnc(Cc2ccccc2)s1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 49 chemicals

1-(5-Benzyl-1,3,4-thiadiazol-2-yl)-3-(4-fluorophenyl)urea chemical structure, C16H13FN4OS, CAS 426249-70-9
1-(5-Benzyl-1,3,4-thiadiazol-2-yl)-3-(4-fluorophenyl)urea
CAS 426249-70-9C16H13FN4OS
1-(5-Benzyl-1,3,4-thiadiazol-2-yl)-3-(2-fluorophenyl)urea chemical structure, C16H13FN4OS, CAS 428477-67-2
1-(5-Benzyl-1,3,4-thiadiazol-2-yl)-3-(2-fluorophenyl)urea
CAS 428477-67-2C16H13FN4OS
1-[5-(4-Fluorobenzyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea chemical structure, C16H12F2N4OS, CAS 428479-71-4
1-[5-(4-Fluorobenzyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea
CAS 428479-71-4C16H12F2N4OS
1-[5-[(4-Fluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]-3-phenylurea chemical structure, C16H13FN4OS, CAS 420808-60-2
1-[5-[(4-Fluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]-3-phenylurea
CAS 420808-60-2C16H13FN4OS
1-(5-Benzyl-1,3,4-thiadiazol-2-yl)-3-(3-methoxyphenyl)urea chemical structure, C17H16N4O2S, CAS 496773-76-3
1-(5-Benzyl-1,3,4-thiadiazol-2-yl)-3-(3-methoxyphenyl)urea
CAS 496773-76-3C17H16N4O2S
1-(4-Chlorophenyl)-3-[5-[(3,4-dimethoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]urea chemical structure, C18H17ClN4O3S, CAS 328561-54-2
1-(4-Chlorophenyl)-3-[5-[(3,4-dimethoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]urea
CAS 328561-54-2C18H17ClN4O3S
1-[5-(4-Methoxybenzyl)-1,3,4-thiadiazol-2-yl]-3-(4-methoxyphenyl)urea chemical structure, C18H18N4O3S, CAS 428478-20-0
1-[5-(4-Methoxybenzyl)-1,3,4-thiadiazol-2-yl]-3-(4-methoxyphenyl)urea
CAS 428478-20-0C18H18N4O3S
1-[5-(3,4-Dimethoxybenzyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea chemical structure, C18H17FN4O3S, CAS 426240-14-4
1-[5-(3,4-Dimethoxybenzyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea
CAS 426240-14-4C18H17FN4O3S
1-(4-Methylphenyl)-3-[5-[(4-nitrophenyl)methyl]-1,3,4-thiadiazol-2-yl]urea chemical structure, C17H15N5O3S, CAS 500106-35-4
1-(4-Methylphenyl)-3-[5-[(4-nitrophenyl)methyl]-1,3,4-thiadiazol-2-yl]urea
CAS 500106-35-4C17H15N5O3S
1-[5-(3-Bromobenzyl)-1,3,4-thiadiazol-2-yl]-3-(4-methoxyphenyl)urea chemical structure, C17H15BrN4O2S, CAS 426235-22-5
1-[5-(3-Bromobenzyl)-1,3,4-thiadiazol-2-yl]-3-(4-methoxyphenyl)urea
CAS 426235-22-5C17H15BrN4O2S
1-(4-Ethoxyphenyl)-3-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]urea chemical structure, C19H20N4O3S, CAS 426243-98-3
1-(4-Ethoxyphenyl)-3-[5-[(4-methoxyphenyl)methyl]-1,3,4-thiadiazol-2-yl]urea
CAS 426243-98-3C19H20N4O3S
1-[5-(3-Bromobenzyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea chemical structure, C16H12BrFN4OS, CAS 426252-28-0
1-[5-(3-Bromobenzyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea
CAS 426252-28-0C16H12BrFN4OS
1-[5-(4-Methoxybenzyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea chemical structure, C18H18N4O2S, CAS 426240-13-3
1-[5-(4-Methoxybenzyl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)urea
CAS 426240-13-3C18H18N4O2S
1-[5-(3-Bromobenzyl)-1,3,4-thiadiazol-2-yl]-3-(3,4-dimethylphenyl)urea chemical structure, C18H17BrN4OS, CAS 429627-31-6
1-[5-(3-Bromobenzyl)-1,3,4-thiadiazol-2-yl]-3-(3,4-dimethylphenyl)urea
CAS 429627-31-6C18H17BrN4OS
1-[5-(3,4-Dimethoxybenzyl)-1,3,4-thiadiazol-2-yl]-3-(3,4-dimethylphenyl)urea chemical structure, C20H22N4O3S, CAS 429627-39-4
1-[5-(3,4-Dimethoxybenzyl)-1,3,4-thiadiazol-2-yl]-3-(3,4-dimethylphenyl)urea
CAS 429627-39-4C20H22N4O3S
1-(3,4-Dimethylphenyl)-3-[5-(4-methoxybenzyl)-1,3,4-thiadiazol-2-yl]urea chemical structure, C19H20N4O2S, CAS 429627-78-1
1-(3,4-Dimethylphenyl)-3-[5-(4-methoxybenzyl)-1,3,4-thiadiazol-2-yl]urea
CAS 429627-78-1C19H20N4O2S
1-[5-[(4-Fluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-methoxyphenyl)urea chemical structure, C17H15FN4O2S, CAS 328561-91-7
1-[5-[(4-Fluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-methoxyphenyl)urea
CAS 328561-91-7C17H15FN4O2S
1-(4-Chlorophenyl)-3-[5-[(4-chlorophenyl)methyl]-1,3,4-thiadiazol-2-yl]urea chemical structure, C16H12Cl2N4OS, CAS 420811-03-6
1-(4-Chlorophenyl)-3-[5-[(4-chlorophenyl)methyl]-1,3,4-thiadiazol-2-yl]urea
CAS 420811-03-6C16H12Cl2N4OS
1-(4-Chlorophenyl)-3-[5-[(4-fluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]urea chemical structure, C16H12ClFN4OS, CAS 424815-02-1
1-(4-Chlorophenyl)-3-[5-[(4-fluorophenyl)methyl]-1,3,4-thiadiazol-2-yl]urea
CAS 424815-02-1C16H12ClFN4OS
1-[5-(4-Nitrobenzyl)-1,3,4-thiadiazol-2-yl]-3-phenylurea chemical structure, C16H13N5O3S, CAS 424815-43-0
1-[5-(4-Nitrobenzyl)-1,3,4-thiadiazol-2-yl]-3-phenylurea
CAS 424815-43-0C16H13N5O3S
1-[5-[(3-Bromophenyl)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-chlorophenyl)urea chemical structure, C16H12BrClN4OS, CAS 424814-57-3
1-[5-[(3-Bromophenyl)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-chlorophenyl)urea
CAS 424814-57-3C16H12BrClN4OS
1-[5-(4-Chlorobenzyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea chemical structure, C16H12ClFN4OS, CAS 426245-79-6
1-[5-(4-Chlorobenzyl)-1,3,4-thiadiazol-2-yl]-3-(4-fluorophenyl)urea
CAS 426245-79-6C16H12ClFN4OS
1-[5-[(3-Bromophenyl)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-ethoxyphenyl)urea chemical structure, C18H17BrN4O2S, CAS 426238-66-6
1-[5-[(3-Bromophenyl)methyl]-1,3,4-thiadiazol-2-yl]-3-(4-ethoxyphenyl)urea
CAS 426238-66-6C18H17BrN4O2S
1-(5-(3,4-Dimethoxybenzyl)-1,3,4-thiadiazol-2-yl)-3-(4-methoxyphenyl)urea chemical structure, C19H20N4O4S, CAS 428482-44-4
1-(5-(3,4-Dimethoxybenzyl)-1,3,4-thiadiazol-2-yl)-3-(4-methoxyphenyl)urea
CAS 428482-44-4C19H20N4O4S