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Murcko scaffold

Ring system with 3 rings and 22 atoms

55 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 22
Chemicals: 55
With full pages: 4

Scaffold SMILES

O=C1NC(=NN=Cc2ccccc2)SC1Cc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C1NC(=NN=Cc2ccccc2)SC1Cc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

(2E)-3-Allyl-5-(3-(trifluoromethyl)benzyl)-1,3-thiazolidine-2,4-dione 2-(((E)-1-(4-fluorophenyl)ethylidene)hydrazone) chemical structure, C22H19F4N3OS, CAS 303093-57-4

(2E)-3-Allyl-5-(3-(trifluoromethyl)benzyl)-1,3-thiazolidine-2,4-dione 2-(((E)-1-(4-fluorophenyl)ethylidene)hydrazone)

CAS 303093-57-4C₂₂H₁₉F₄N₃OS

(Z)-3-Allyl-5-benzyl-2-((E)-benzylidenehydrazono)thiazolidin-4-one chemical structure, C20H19N3OS, CAS 301227-82-7

(Z)-3-Allyl-5-benzyl-2-((E)-benzylidenehydrazono)thiazolidin-4-one

CAS 301227-82-7C₂₀H₁₉N₃OS

(Z)-3-Allyl-2-((E)-(4-chlorobenzylidene)hydrazono)-5-(2-methylbenzyl)thiazolidin-4-one chemical structure, C21H20ClN3OS, CAS 461693-74-3

(Z)-3-Allyl-2-((E)-(4-chlorobenzylidene)hydrazono)-5-(2-methylbenzyl)thiazolidin-4-one

CAS 461693-74-3C₂₁H₂₀ClN₃OS

(2Z)-5-(3-Methylbenzyl)-2-[(2E)-(3-nitrobenzylidene)hydrazinylidene]-1,3-thiazolidin-4-one chemical structure, C18H16N4O3S, CAS 327075-42-3

(2Z)-5-(3-Methylbenzyl)-2-[(2E)-(3-nitrobenzylidene)hydrazinylidene]-1,3-thiazolidin-4-one

CAS 327075-42-3C₁₈H₁₆N₄O₃S

(Z)-2-((E)-(4-(Dimethylamino)benzylidene)hydrazono)-5-(2-methylbenzyl)thiazolidin-4-one chemical structure, C20H22N4OS, CAS 303792-15-6

(Z)-2-((E)-(4-(Dimethylamino)benzylidene)hydrazono)-5-(2-methylbenzyl)thiazolidin-4-one

CAS 303792-15-6C₂₀H₂₂N₄OS

(Z)-5-(4-Chlorobenzyl)-2-((E)-(4-(dimethylamino)benzylidene)hydrazono)thiazolidin-4-one chemical structure, C19H19ClN4OS, CAS 292051-98-0

(Z)-5-(4-Chlorobenzyl)-2-((E)-(4-(dimethylamino)benzylidene)hydrazono)thiazolidin-4-one

CAS 292051-98-0C₁₉H₁₉ClN₄OS

2-((E)-(4-Hydroxybenzylidene)hydrazono)-5-(3-methylbenzyl)thiazolidin-4-one chemical structure, C18H17N3O2S, CAS 306321-27-7

2-((E)-(4-Hydroxybenzylidene)hydrazono)-5-(3-methylbenzyl)thiazolidin-4-one

CAS 306321-27-7C₁₈H₁₇N₃O₂S

(2Z)-2-[(2E)-(4-Hydroxybenzylidene)hydrazinylidene]-5-(2-nitrobenzyl)-1,3-thiazolidin-4-one chemical structure, C17H14N4O4S, CAS 290835-29-9

(2Z)-2-[(2E)-(4-Hydroxybenzylidene)hydrazinylidene]-5-(2-nitrobenzyl)-1,3-thiazolidin-4-one

CAS 290835-29-9C₁₇H₁₄N₄O₄S

4-Methoxybenzaldehyde [5-(2,4-dichlorobenzyl)-4-oxo-1,3-thiazolidin-2-ylidene]hydrazone chemical structure, C18H15Cl2N3O2S, CAS 314258-24-7

4-Methoxybenzaldehyde [5-(2,4-dichlorobenzyl)-4-oxo-1,3-thiazolidin-2-ylidene]hydrazone

CAS 314258-24-7C₁₈H₁₅Cl₂N₃O₂S

(2Z)-2-[(2E)-Benzylidenehydrazinylidene]-5-(3-methylbenzyl)-2,5-dihydro-1,3-thiazol-4-ol chemical structure, C18H17N3OS, CAS 5325-11-1

(2Z)-2-[(2E)-Benzylidenehydrazinylidene]-5-(3-methylbenzyl)-2,5-dihydro-1,3-thiazol-4-ol

CAS 5325-11-1C₁₈H₁₇N₃OS

(2Z)-5-(2-Methylbenzyl)-2-[(2E)-(3-nitrobenzylidene)hydrazinylidene]-1,3-thiazolidin-4-one chemical structure, C18H16N4O3S, CAS 327074-36-2

(2Z)-5-(2-Methylbenzyl)-2-[(2E)-(3-nitrobenzylidene)hydrazinylidene]-1,3-thiazolidin-4-one

CAS 327074-36-2C₁₈H₁₆N₄O₃S

(Z)-2-((E)-(4-(Dimethylamino)benzylidene)hydrazono)-5-(3-methylbenzyl)thiazolidin-4-one chemical structure, C20H22N4OS, CAS 306321-34-6

(Z)-2-((E)-(4-(Dimethylamino)benzylidene)hydrazono)-5-(3-methylbenzyl)thiazolidin-4-one

CAS 306321-34-6C₂₀H₂₂N₄OS

5-[[4-(Difluoromethylsulfanyl)phenyl]methyl]-2-[(2-hydroxyphenyl)methylidenehydrazinylidene]-1,3-thiazolidin-4-one chemical structure, C18H15F2N3O2S2

5-[[4-(Difluoromethylsulfanyl)phenyl]methyl]-2-[(2-hydroxyphenyl)methylidenehydrazinylidene]-1,3-thiazolidin-4-one

C₁₈H₁₅F₂N₃O₂S₂

5-[(2,6-Dichlorophenyl)methyl]-2-[(2-methoxyphenyl)methylidenehydrazinylidene]-1,3-thiazolidin-4-one chemical structure, C18H15Cl2N3O2S

5-[(2,6-Dichlorophenyl)methyl]-2-[(2-methoxyphenyl)methylidenehydrazinylidene]-1,3-thiazolidin-4-one

C₁₈H₁₅Cl₂N₃O₂S

(Z)-5-Benzyl-2-((E)-(1-phenylethylidene)hydrazono)thiazolidin-4-one chemical structure, C18H17N3OS, CAS 463325-17-9

(Z)-5-Benzyl-2-((E)-(1-phenylethylidene)hydrazono)thiazolidin-4-one

CAS 463325-17-9C₁₈H₁₇N₃OS

(Z)-5-(4-Ethoxybenzyl)-2-((E)-(4-methoxybenzylidene)hydrazono)thiazolidin-4-one chemical structure, C20H21N3O3S

(Z)-5-(4-Ethoxybenzyl)-2-((E)-(4-methoxybenzylidene)hydrazono)thiazolidin-4-one

C₂₀H₂₁N₃O₃S

(2Z)-5-(4-Bromobenzyl)-2-{(2E)-[4-(dimethylamino)benzylidene]hydrazinylidene}-2,5-dihydro-1,3-thiazol-4-ol chemical structure, C19H19BrN4OS, CAS 301175-22-4

(2Z)-5-(4-Bromobenzyl)-2-{(2E)-[4-(dimethylamino)benzylidene]hydrazinylidene}-2,5-dihydro-1,3-thiazol-4-ol

CAS 301175-22-4C₁₉H₁₉BrN₄OS

(2Z)-5-(3-Chlorobenzyl)-2-[(2E)-(3,4-dimethoxybenzylidene)hydrazinylidene]-1,3-thiazolidin-4-one chemical structure, C19H18ClN3O3S, CAS 301174-88-9

(2Z)-5-(3-Chlorobenzyl)-2-[(2E)-(3,4-dimethoxybenzylidene)hydrazinylidene]-1,3-thiazolidin-4-one

CAS 301174-88-9C₁₉H₁₈ClN₃O₃S

5-[(3,4-Dichlorophenyl)methyl]-2-[(2E)-2-[(3,4-dimethoxyphenyl)methylidene]hydrazinyl]-1,3-thiazol-4-one chemical structure, C19H17Cl2N3O3S, CAS 327062-19-1

5-[(3,4-Dichlorophenyl)methyl]-2-[(2E)-2-[(3,4-dimethoxyphenyl)methylidene]hydrazinyl]-1,3-thiazol-4-one

CAS 327062-19-1C₁₉H₁₇Cl₂N₃O₃S

(Z)-2-((E)-Benzylidenehydrazono)-5-(4-bromobenzyl)thiazolidin-4-one chemical structure, C17H14BrN3OS, CAS 301174-69-6

(Z)-2-((E)-Benzylidenehydrazono)-5-(4-bromobenzyl)thiazolidin-4-one

CAS 301174-69-6C₁₇H₁₄BrN₃OS

5-[(4-Bromophenyl)methyl]-2-[(2E)-2-[(2-methoxyphenyl)methylidene]hydrazinyl]-1,3-thiazol-4-one chemical structure, C18H16BrN3O2S, CAS 301174-86-7

5-[(4-Bromophenyl)methyl]-2-[(2E)-2-[(2-methoxyphenyl)methylidene]hydrazinyl]-1,3-thiazol-4-one

CAS 301174-86-7C₁₈H₁₆BrN₃O₂S

5-[(4-Fluorophenyl)methyl]-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]-1,3-thiazol-4-one chemical structure, C18H16FN3O2S, CAS 327063-46-7

5-[(4-Fluorophenyl)methyl]-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]-1,3-thiazol-4-one

CAS 327063-46-7C₁₈H₁₆FN₃O₂S

(2Z)-2-[(2E)-2-{[4-(Dimethylamino)phenyl]methylidene}hydrazin-1-ylidene]-5-{[3-(trifluoromethyl)phenyl]methyl}-1,3-thiazolidin-4-one chemical structure, C20H19F3N4OS, CAS 292056-90-7

(2Z)-2-[(2E)-2-{[4-(Dimethylamino)phenyl]methylidene}hydrazin-1-ylidene]-5-{[3-(trifluoromethyl)phenyl]methyl}-1,3-thiazolidin-4-one

CAS 292056-90-7C₂₀H₁₉F₃N₄OS

(Z)-2-((E)-(2-Chlorobenzylidene)hydrazono)-5-(4-ethoxybenzyl)thiazolidin-4-one chemical structure, C19H18ClN3O2S, CAS 301174-75-4

(Z)-2-((E)-(2-Chlorobenzylidene)hydrazono)-5-(4-ethoxybenzyl)thiazolidin-4-one

CAS 301174-75-4C₁₉H₁₈ClN₃O₂S