Murcko scaffold
Ring system with 3 rings and 24 atoms
110 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 24
- Chemicals
- 110
- With full pages
- 5
Scaffold SMILES
O=C(CN1C(=O)SC(=Cc2ccccc2)C1=O)Nc1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 110 chemicals
![2-[(5Z)-5-(2,4-Diethoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide chemical structure, C23H24N2O5S, CAS 430468-68-1](/s/PVMQPMSYPSCSFQ-NDENLUEZSA-N.svg)
2-[(5Z)-5-(2,4-Diethoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide
CAS 430468-68-1C23H24N2O5S
![2-[(5Z)-5-[(3-Chloro-5-ethoxy-4-hydroxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide chemical structure, C21H19ClN2O5S, CAS 431066-39-6](/s/GIKDUOJRUFZKBU-YVLHZVERSA-N.svg)
2-[(5Z)-5-[(3-Chloro-5-ethoxy-4-hydroxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide
CAS 431066-39-6C21H19ClN2O5S
![2-[(5Z)-5-(3-Ethoxy-4-hydroxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide chemical structure, C21H20N2O5S, CAS 431056-62-1](/s/AVGBQADAPYDLDV-WQRHYEAKSA-N.svg)
2-[(5Z)-5-(3-Ethoxy-4-hydroxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide
CAS 431056-62-1C21H20N2O5S
![2-[5-(3,4-Dimethoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide chemical structure, C20H17FN2O5S, CAS 430471-15-1](/s/TXXMJNCHIOTWEK-YVLHZVERSA-N.svg)
2-[5-(3,4-Dimethoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide
CAS 430471-15-1C20H17FN2O5S
![N-(2-Fluorophenyl)-2-[(5Z)-5-(4-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide chemical structure, C19H15FN2O4S, CAS 430469-19-5](/s/USOTUWFUUNUYDF-YBEGLDIGSA-N.svg)
N-(2-Fluorophenyl)-2-[(5Z)-5-(4-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
CAS 430469-19-5C19H15FN2O4S
![2-[2,4-Dioxo-5-(2,4,6-trimethoxybenzylidene)-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide chemical structure, C21H19FN2O6S, CAS 431893-23-1](/s/ORKPWFBDNWEFJZ-ZDLGFXPLSA-N.svg)
2-[2,4-Dioxo-5-(2,4,6-trimethoxybenzylidene)-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide
CAS 431893-23-1C21H19FN2O6S
(Z)-4-(2-(5-(4-Chlorobenzylidene)-2,4-dioxothiazolidin-3-yl)acetamido)benzoic acid
CAS 514201-57-1C19H13ClN2O5S
![2-[(5Z)-5-(2,3-Dimethoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide chemical structure, C20H17FN2O5S, CAS 431057-41-9](/s/UXSJSZVHIAATES-YBEGLDIGSA-N.svg)
2-[(5Z)-5-(2,3-Dimethoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide
CAS 431057-41-9C20H17FN2O5S
![2-[(5Z)-5-[(5-Chloro-2-hydroxy-3-methoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide chemical structure, C19H14ClFN2O5S, CAS 431941-84-3](/s/IHNJYQUXYBMDKQ-CHHVJCJISA-N.svg)
2-[(5Z)-5-[(5-Chloro-2-hydroxy-3-methoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide
CAS 431941-84-3C19H14ClFN2O5S
![2-[(5Z)-5-(2-Ethoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide chemical structure, C21H20N2O4S, CAS 431979-23-6](/s/XHLYJKSMWNRKDS-PDGQHHTCSA-N.svg)
2-[(5Z)-5-(2-Ethoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide
CAS 431979-23-6C21H20N2O4S
![N-(3,4-Dimethylphenyl)-2-[(5E)-5-(4-methylbenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide chemical structure, C21H20N2O3S, CAS 432515-03-2](/s/GETHMOZZEPVXML-WOJGMQOQSA-N.svg)
N-(3,4-Dimethylphenyl)-2-[(5E)-5-(4-methylbenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
CAS 432515-03-2C21H20N2O3S
![2-[(5E)-5-(3,4-Diethoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(3,4-dimethylphenyl)acetamide chemical structure, C24H26N2O5S, CAS 432533-05-6](/s/GFSSQXZEQFSABY-FYJGNVAPSA-N.svg)
2-[(5E)-5-(3,4-Diethoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(3,4-dimethylphenyl)acetamide
CAS 432533-05-6C24H26N2O5S
![N-(2-Fluorophenyl)-2-[(5E)-5-(2-hydroxy-3-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide chemical structure, C19H15FN2O5S, CAS 431066-42-1](/s/SUTOPYAQSVYCTR-OQLLNIDSSA-N.svg)
N-(2-Fluorophenyl)-2-[(5E)-5-(2-hydroxy-3-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
CAS 431066-42-1C19H15FN2O5S
![N-(2-Fluorophenyl)-2-[(5Z)-5-(4-methoxy-3-methylbenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide chemical structure, C20H17FN2O4S, CAS 431075-10-4](/s/JDCVTVTYNRIQNN-YVLHZVERSA-N.svg)
N-(2-Fluorophenyl)-2-[(5Z)-5-(4-methoxy-3-methylbenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
CAS 431075-10-4C20H17FN2O4S
![2-[(5Z)-5-[[4-(Diethylamino)phenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide chemical structure, C22H22FN3O3S, CAS 431075-87-5](/s/OMKADZKFXQXGOX-UYRXBGFRSA-N.svg)
2-[(5Z)-5-[[4-(Diethylamino)phenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide
CAS 431075-87-5C22H22FN3O3S
![2-[(5Z)-2,4-Dioxo-5-(2,3,4-trimethoxybenzylidene)-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide chemical structure, C21H19FN2O6S, CAS 431883-00-0](/s/LVAMNLMXYAQHCH-YBEGLDIGSA-N.svg)
2-[(5Z)-2,4-Dioxo-5-(2,3,4-trimethoxybenzylidene)-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide
CAS 431883-00-0C21H19FN2O6S
![2-[(5Z)-5-(4-Ethylbenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide chemical structure, C21H20N2O3S, CAS 432009-08-0](/s/DPWVMFKCFGIERW-PDGQHHTCSA-N.svg)
2-[(5Z)-5-(4-Ethylbenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide
CAS 432009-08-0C21H20N2O3S
![5-[[4-(2-Amino-2-oxoethoxy)phenyl]methylene]-N-(3-methylphenyl)-2,4-dioxo-3-thiazolidineacetamide chemical structure, C21H19N3O5S, CAS 432010-15-6](/s/QPWBNASRBFQENL-UHFFFAOYSA-N.svg)
5-[[4-(2-Amino-2-oxoethoxy)phenyl]methylene]-N-(3-methylphenyl)-2,4-dioxo-3-thiazolidineacetamide
CAS 432010-15-6C21H19N3O5S
![N-(3,4-Dimethylphenyl)-2-[(5E)-5-(3-methylbenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide chemical structure, C21H20N2O3S, CAS 432011-87-5](/s/AGOBCSRTLBHHPR-WOJGMQOQSA-N.svg)
N-(3,4-Dimethylphenyl)-2-[(5E)-5-(3-methylbenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
CAS 432011-87-5C21H20N2O3S
![2-[(5Z)-5-(3-Bromo-4-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide chemical structure, C19H14BrFN2O4S, CAS 431886-45-2](/s/BHGXZNSXWGBUEV-SXGWCWSVSA-N.svg)
2-[(5Z)-5-(3-Bromo-4-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide
CAS 431886-45-2C19H14BrFN2O4S
![Methyl 4-[(Z)-(3-{2-[(2-fluorophenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoate chemical structure, C20H15FN2O5S, CAS 432012-37-8](/s/SLDMQZDGGISMHH-YBEGLDIGSA-N.svg)
Methyl 4-[(Z)-(3-{2-[(2-fluorophenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzoate
CAS 432012-37-8C20H15FN2O5S
![N-(2-Fluorophenyl)-2-[(5Z)-5-(3-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide chemical structure, C19H15FN2O4S, CAS 431916-29-9](/s/BOEWSNCBYTZVDG-YBEGLDIGSA-N.svg)
N-(2-Fluorophenyl)-2-[(5Z)-5-(3-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
CAS 431916-29-9C19H15FN2O4S
![2-[(5Z)-5-[(5-Chloro-2-methoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide chemical structure, C19H14ClFN2O4S, CAS 431922-80-4](/s/YGUXVBZKDYTNPE-SXGWCWSVSA-N.svg)
2-[(5Z)-5-[(5-Chloro-2-methoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide
CAS 431922-80-4C19H14ClFN2O4S
![2-[(5Z)-5-(3-Ethoxy-2-hydroxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide chemical structure, C21H20N2O5S, CAS 431923-47-6](/s/RAWFIDAVEQHTFR-BOPFTXTBSA-N.svg)
2-[(5Z)-5-(3-Ethoxy-2-hydroxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide
CAS 431923-47-6C21H20N2O5S
- 2-[(5Z)-5-(3-Bromo-4-ethoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide431924-65-1C21H19BrN2O4S
- 2-[(5Z)-5-(2-Ethoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide431927-53-6C20H17FN2O4S
- 2-[(5Z)-5-(2,5-Dimethoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide431926-05-5C20H17FN2O5S
- N-(4-Fluorophenyl)-2-[(5Z)-5-[(3-hydroxy-4-methoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide429635-48-3C19H15FN2O5S
- 2-[(5Z)-5-(3,4-Dimethoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-hydroxyphenyl)acetamide429643-99-2C20H18N2O6S
- 2-[(5E)-5-[(2-Fluorophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(3-hydroxyphenyl)acetamide6028-70-2C18H13FN2O4S
- 2-[(5Z)-5-[(3-Methoxy-4-propan-2-yloxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide431929-53-2C23H24N2O5S
- 2-[(5Z)-5-[[4-(2-Amino-2-oxoethoxy)-3-methoxyphenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide431912-73-1C21H18FN3O6S
- 2-[(5E)-5-(5-Chloro-2-hydroxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(3,4-dimethylphenyl)acetamide431909-10-3C20H17ClN2O4S
- 2-[(5Z)-5-(3-Chloro-4-hydroxy-5-methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide431066-72-7C20H17ClN2O5S
- Methyl {4-[(Z)-(3-{2-[(4-methylphenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetate431890-31-2C22H20N2O6S
- Methyl {2-[(Z)-(3-{2-[(4-methylphenyl)amino]-2-oxoethyl}-2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]phenoxy}acetate431053-78-0C22H20N2O6S
- 2-[(5E)-5-[(2-Hydroxy-3-methoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide431055-86-6C20H18N2O5S
- N-(3,4-Dimethylphenyl)-2-[(5E)-5-[(4-ethoxy-2-methyl-5-propan-2-ylphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide431918-28-4C26H30N2O4S
- 2-{5-[(3,4-Dimethoxyphenyl)methylene]-2,4-dioxo(1,3-thiazolidin-3-yl)}-N-(2-me thylphenyl)acetamide430445-19-5C21H20N2O5S
- 2-[(5Z)-5-[(4-Ethylphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-sulfamoylphenyl)acetamide637326-71-7C20H19N3O5S2
- N-(2-Fluorophenyl)-2-[(5Z)-5-(4-hydroxy-3-methoxy-5-nitrobenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide431919-65-2C19H14FN3O7S
- N-(4-Methylphenyl)-2-[(5Z)-5-[(4-methylsulfanylphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide431892-80-7C20H18N2O3S2
- 2-[5-(4-Methoxy-3-methylbenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide431895-42-0C21H20N2O4S
- 2-[(5Z)-2,4-Dioxo-5-[(4-prop-2-enoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide431884-96-7C22H20N2O4S
- 2-[(5Z)-5-(3-Methoxybenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide430470-73-8C20H18N2O4S
- 2-[(5Z)-2,4-Dioxo-5-[(4-prop-2-ynoxyphenyl)methylidene]-1,3-thiazolidin-3-yl]-N-(4-methylphenyl)acetamide431075-55-7C22H18N2O4S
- 2-[(5Z)-5-[(3-Ethoxy-4-hydroxy-5-nitrophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide430469-29-7C20H16FN3O7S
- 2-[(5Z)-5-[(3,5-Dichloro-4-prop-2-ynoxyphenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2-fluorophenyl)acetamide431056-31-4C21H13Cl2FN2O4S
Related scaffolds
Same ring framework with different atoms or bond orders
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