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Murcko scaffold

Ring system with 3 rings and 24 atoms

15 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
15
With full pages
6
Scaffold SMILES

O=C(CCN1C(=O)C(=Cc2ccccc2)SC1=S)N1CCCCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCN1C(=O)C(=Cc2ccccc2)SC1=S)N1CCCCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 15 of 15 chemicals

(E)-5-(3-Methoxybenzylidene)-3-(3-oxo-3-(piperidin-1-yl)propyl)-2-thioxothiazolidin-4-one chemical structure, C19H22N2O3S2, CAS 300827-04-7
(E)-5-(3-Methoxybenzylidene)-3-(3-oxo-3-(piperidin-1-yl)propyl)-2-thioxothiazolidin-4-one
CAS 300827-04-7C19H22N2O3S2
(E)-5-(4-Methoxybenzylidene)-3-(3-oxo-3-(piperidin-1-yl)propyl)-2-thioxothiazolidin-4-one chemical structure, C19H22N2O3S2, CAS 307525-60-6
(E)-5-(4-Methoxybenzylidene)-3-(3-oxo-3-(piperidin-1-yl)propyl)-2-thioxothiazolidin-4-one
CAS 307525-60-6C19H22N2O3S2
(Z)-5-(4-Methylbenzylidene)-3-(3-oxo-3-(piperidin-1-yl)propyl)-2-thioxothiazolidin-4-one chemical structure, C19H22N2O2S2, CAS 300827-06-9
(Z)-5-(4-Methylbenzylidene)-3-(3-oxo-3-(piperidin-1-yl)propyl)-2-thioxothiazolidin-4-one
CAS 300827-06-9C19H22N2O2S2
(E)-5-(2-Chlorobenzylidene)-3-(3-oxo-3-(piperidin-1-yl)propyl)-2-thioxothiazolidin-4-one chemical structure, C18H19ClN2O2S2, CAS 380881-70-9
(E)-5-(2-Chlorobenzylidene)-3-(3-oxo-3-(piperidin-1-yl)propyl)-2-thioxothiazolidin-4-one
CAS 380881-70-9C18H19ClN2O2S2
(5E)-5-[(2-Fluorophenyl)methylidene]-3-[3-(4-methylpiperidin-1-yl)-3-oxopropyl]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C19H21FN2O2S2, CAS 477488-33-8
(5E)-5-[(2-Fluorophenyl)methylidene]-3-[3-(4-methylpiperidin-1-yl)-3-oxopropyl]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 477488-33-8C19H21FN2O2S2
3-{3-[2-(2-Hydroxyethyl)piperidyl]-3-oxopropyl}-5-[(2-methoxyphenyl)methylene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C21H26N2O4S2, CAS 902039-03-6
3-{3-[2-(2-Hydroxyethyl)piperidyl]-3-oxopropyl}-5-[(2-methoxyphenyl)methylene]-2-thioxo-1,3-thiazolidin-4-one
CAS 902039-03-6C21H26N2O4S2
5-[(3-Fluorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H23FN2O3S2, CAS 902014-72-6
5-[(3-Fluorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-2-thioxo-1,3-thiazolidin-4-one
CAS 902014-72-6C20H23FN2O3S2
5-[(2-Fluorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H23FN2O3S2, CAS 902021-49-2
5-[(2-Fluorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-2-thioxo-1,3-thiazolidin-4-one
CAS 902021-49-2C20H23FN2O3S2
1-{3-[(5Z)-5-(3-Methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoyl}piperidine-4-carboxylic acid chemical structure, C20H22N2O5S2, CAS 902043-28-1
1-{3-[(5Z)-5-(3-Methoxybenzylidene)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]propanoyl}piperidine-4-carboxylic acid
CAS 902043-28-1C20H22N2O5S2
(5Z)-5-(4-Chlorobenzylidene)-3-{3-[2-(2-hydroxyethyl)piperidin-1-yl]-3-oxopropyl}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H23ClN2O3S2, CAS 902035-68-1
(5Z)-5-(4-Chlorobenzylidene)-3-{3-[2-(2-hydroxyethyl)piperidin-1-yl]-3-oxopropyl}-2-thioxo-1,3-thiazolidin-4-one
CAS 902035-68-1C20H23ClN2O3S2
(5Z)-3-{3-[2-(2-Hydroxyethyl)piperidin-1-yl]-3-oxopropyl}-5-[4-(propan-2-yl)benzylidene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C23H30N2O3S2, CAS 902327-32-6
(5Z)-3-{3-[2-(2-Hydroxyethyl)piperidin-1-yl]-3-oxopropyl}-5-[4-(propan-2-yl)benzylidene]-2-thioxo-1,3-thiazolidin-4-one
CAS 902327-32-6C23H30N2O3S2
5-[(3-Chlorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-2-thioxo-1,3-thiazolidin-4-one chemical structure, C20H23ClN2O3S2, CAS 902306-34-7
5-[(3-Chlorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-2-thioxo-1,3-thiazolidin-4-one
CAS 902306-34-7C20H23ClN2O3S2
3-{3-[2-(2-Hydroxyethyl)piperidyl]-3-oxopropyl}-5-[(3-methoxyphenyl)methylene]-2-thioxo-1,3-thiazolidin-4-one chemical structure, C21H26N2O4S2, CAS 892623-88-0
3-{3-[2-(2-Hydroxyethyl)piperidyl]-3-oxopropyl}-5-[(3-methoxyphenyl)methylene]-2-thioxo-1,3-thiazolidin-4-one
CAS 892623-88-0C21H26N2O4S2
(E)-5-(2-Fluorobenzylidene)-3-(3-oxo-3-(piperidin-1-yl)propyl)-2-thioxothiazolidin-4-one chemical structure, C18H19FN2O2S2, CAS 477488-31-6
(E)-5-(2-Fluorobenzylidene)-3-(3-oxo-3-(piperidin-1-yl)propyl)-2-thioxothiazolidin-4-one
CAS 477488-31-6C18H19FN2O2S2
(5Z)-5-[(2-Methoxyphenyl)methylidene]-3-[3-(4-methylpiperidin-1-yl)-3-oxopropyl]-2-sulfanylidene-1,3-thiazolidin-4-one chemical structure, C20H24N2O3S2, CAS 681480-36-4
(5Z)-5-[(2-Methoxyphenyl)methylidene]-3-[3-(4-methylpiperidin-1-yl)-3-oxopropyl]-2-sulfanylidene-1,3-thiazolidin-4-one
CAS 681480-36-4C20H24N2O3S2