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Murcko scaffold

Ring system with 3 rings and 24 atoms

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
24
Chemicals
12
With full pages
3
Scaffold SMILES

O=C(CCN1C(=O)SC(=Cc2ccccc2)C1=O)N1CCCCC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CCN1C(=O)SC(=Cc2ccccc2)C1=O)N1CCCCC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

3-{3-[2-(2-Hydroxyethyl)piperidyl]-3-oxopropyl}-5-[(2-methoxyphenyl)methylene]-1,3-thiazolidine-2,4-dione chemical structure, C21H26N2O5S, CAS 902014-11-3
3-{3-[2-(2-Hydroxyethyl)piperidyl]-3-oxopropyl}-5-[(2-methoxyphenyl)methylene]-1,3-thiazolidine-2,4-dione
CAS 902014-11-3C21H26N2O5S
5-[(3-Fluorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-1,3-thiazolidine-2,4-dione chemical structure, C20H23FN2O4S, CAS 902019-60-7
5-[(3-Fluorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-1,3-thiazolidine-2,4-dione
CAS 902019-60-7C20H23FN2O4S
1-{3-[(5Z)-5-(4-Fluorobenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]propanoyl}piperidine-4-carboxylic acid chemical structure, C19H19FN2O5S, CAS 902033-75-4
1-{3-[(5Z)-5-(4-Fluorobenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]propanoyl}piperidine-4-carboxylic acid
CAS 902033-75-4C19H19FN2O5S
5-[(2-Fluorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-1,3-thiazolidine-2,4-dione chemical structure, C20H23FN2O4S, CAS 902016-48-2
5-[(2-Fluorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-1,3-thiazolidine-2,4-dione
CAS 902016-48-2C20H23FN2O4S
1-{3-[(5Z)-5-(2-Fluorobenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]propanoyl}piperidine-4-carboxylic acid chemical structure, C19H19FN2O5S, CAS 902035-77-2
1-{3-[(5Z)-5-(2-Fluorobenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]propanoyl}piperidine-4-carboxylic acid
CAS 902035-77-2C19H19FN2O5S
3-{3-[2-(2-Hydroxyethyl)piperidyl]-3-oxopropyl}-5-[(4-methoxyphenyl)methylene]-1,3-thiazolidine-2,4-dione chemical structure, C21H26N2O5S, CAS 902031-02-1
3-{3-[2-(2-Hydroxyethyl)piperidyl]-3-oxopropyl}-5-[(4-methoxyphenyl)methylene]-1,3-thiazolidine-2,4-dione
CAS 902031-02-1C21H26N2O5S
5-[(4-Chlorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-1,3-thiazolidine-2,4-dione chemical structure, C20H23ClN2O4S, CAS 904502-67-6
5-[(4-Chlorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-1,3-thiazolidine-2,4-dione
CAS 904502-67-6C20H23ClN2O4S
1-{3-[(5Z)-5-(3-Chlorobenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]propanoyl}piperidine-4-carboxylic acid chemical structure, C19H19ClN2O5S, CAS 902306-64-3
1-{3-[(5Z)-5-(3-Chlorobenzylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]propanoyl}piperidine-4-carboxylic acid
CAS 902306-64-3C19H19ClN2O5S
1-{3-[(5Z)-5-Benzylidene-2,4-dioxo-1,3-thiazolidin-3-yl]propanoyl}piperidine-4-carboxylic acid chemical structure, C19H20N2O5S, CAS 902324-94-1
1-{3-[(5Z)-5-Benzylidene-2,4-dioxo-1,3-thiazolidin-3-yl]propanoyl}piperidine-4-carboxylic acid
CAS 902324-94-1C19H20N2O5S
5-[(4-Fluorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-1,3-thiazolidine-2,4-dione chemical structure, C20H23FN2O4S, CAS 902323-59-5
5-[(4-Fluorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-1,3-thiazolidine-2,4-dione
CAS 902323-59-5C20H23FN2O4S
5-[(2-Chlorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-1,3-thiazolidine-2,4-dione chemical structure, C20H23ClN2O4S, CAS 902305-59-3
5-[(2-Chlorophenyl)methylene]-3-{3-[2-(2-hydroxyethyl)piperidyl]-3-oxopropyl}-1,3-thiazolidine-2,4-dione
CAS 902305-59-3C20H23ClN2O4S
(5Z)-5-(3-Chlorobenzylidene)-3-{3-[2-(2-hydroxyethyl)piperidin-1-yl]-3-oxopropyl}-1,3-thiazolidine-2,4-dione chemical structure, C20H23ClN2O4S, CAS 902322-12-7
(5Z)-5-(3-Chlorobenzylidene)-3-{3-[2-(2-hydroxyethyl)piperidin-1-yl]-3-oxopropyl}-1,3-thiazolidine-2,4-dione
CAS 902322-12-7C20H23ClN2O4S