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Murcko scaffold

4-Phenyl-1,2,3,4-tetrahydroquinoline scaffold

55 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
16
Chemicals
55
With full pages
10
Scaffold SMILES

c1ccc(C2CCNc3ccccc32)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 4-Phenyl-1,2,3,4-tetrahydroquinoline page
Murcko scaffold c1ccc(C2CCNc3ccccc32)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 55 chemicals

1-Methyl-4-phenyl-1,2,3,4-tetrahydroquinoline chemical structure, C16H17N, CAS 27623-83-2
1-Methyl-4-phenyl-1,2,3,4-tetrahydroquinoline
CAS 27623-83-2C16H17N
4-(3,5-Dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroquinoline chemical structure, C19H23NO4, CAS 7473-33-8
4-(3,5-Dimethoxyphenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroquinoline
CAS 7473-33-8C19H23NO4
1-Acetyl-2,2,4-trimethyl-4-phenyl-1,2,3,4-tetrahydroquinoline chemical structure, C20H23NO, CAS 13562-25-9
1-Acetyl-2,2,4-trimethyl-4-phenyl-1,2,3,4-tetrahydroquinoline
CAS 13562-25-9C20H23NO
1-[4-(4-Methoxyphenyl)-2,2,4-trimethyl-3H-quinolin-1-yl]ethanone chemical structure, C21H25NO2, CAS 113279-29-1
1-[4-(4-Methoxyphenyl)-2,2,4-trimethyl-3H-quinolin-1-yl]ethanone
CAS 113279-29-1C21H25NO2
1-(2,2,4-Trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)propan-1-one chemical structure, C21H25NO, CAS 84816-95-5
1-(2,2,4-Trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)propan-1-one
CAS 84816-95-5C21H25NO
N-(1-Acetyl-2,2,4-trimethyl-4-phenyl-3H-quinolin-6-yl)-2,2,2-trifluoroacetamide chemical structure, C22H23F3N2O2, CAS 360760-14-1
N-(1-Acetyl-2,2,4-trimethyl-4-phenyl-3H-quinolin-6-yl)-2,2,2-trifluoroacetamide
CAS 360760-14-1C22H23F3N2O2
2,2,4-Trimethyl-4-phenyl-6-thiocyanato-1,2,3,4-tetrahydroquinoline chemical structure, C19H20N2S, CAS 300689-80-9
2,2,4-Trimethyl-4-phenyl-6-thiocyanato-1,2,3,4-tetrahydroquinoline
CAS 300689-80-9C19H20N2S
1-(6-Amino-2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)ethanone chemical structure, C20H24N2O, CAS 332904-33-3
1-(6-Amino-2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)ethanone
CAS 332904-33-3C20H24N2O
1-[4-(4-Butylphenyl)-2,2,4-trimethyl-3H-quinolin-1-yl]ethanone chemical structure, C24H31NO, CAS 84825-21-8
1-[4-(4-Butylphenyl)-2,2,4-trimethyl-3H-quinolin-1-yl]ethanone
CAS 84825-21-8C24H31NO
1-(2,2,4-Trimethyl-4-phenyl-3H-quinolin-1-yl)pentan-1-one chemical structure, C23H29NO, CAS 84816-97-7
1-(2,2,4-Trimethyl-4-phenyl-3H-quinolin-1-yl)pentan-1-one
CAS 84816-97-7C23H29NO
1-(2,2,4-Trimethyl-4-phenyl-3H-quinolin-1-yl)butan-1-one chemical structure, C22H27NO, CAS 84816-96-6
1-(2,2,4-Trimethyl-4-phenyl-3H-quinolin-1-yl)butan-1-one
CAS 84816-96-6C22H27NO
1-[4-(4-Bromophenyl)-2,2,4-trimethyl-3H-quinolin-1-yl]ethanone chemical structure, C20H22BrNO, CAS 35053-09-9
1-[4-(4-Bromophenyl)-2,2,4-trimethyl-3H-quinolin-1-yl]ethanone
CAS 35053-09-9C20H22BrNO
Ethyl oxo(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)acetate chemical structure, C22H25NO3, CAS 351223-90-0
Ethyl oxo(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)acetate
CAS 351223-90-0C22H25NO3
2-Oxo-2-(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)ethyl thiocyanate chemical structure, C21H22N2OS, CAS 378212-73-8
2-Oxo-2-(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)ethyl thiocyanate
CAS 378212-73-8C21H22N2OS
1-[4-(4-Chlorophenyl)-2,2,4-trimethyl-3H-quinolin-1-yl]-2-(2-methoxyethoxy)ethanone chemical structure, C23H28ClNO3, CAS 377065-12-8
1-[4-(4-Chlorophenyl)-2,2,4-trimethyl-3H-quinolin-1-yl]-2-(2-methoxyethoxy)ethanone
CAS 377065-12-8C23H28ClNO3
Ethyl 2,2,4-trimethyl-4-phenyl-3,4-dihydroquinoline-1(2H)-carboxylate chemical structure, C21H25NO2, CAS 376625-03-5
Ethyl 2,2,4-trimethyl-4-phenyl-3,4-dihydroquinoline-1(2H)-carboxylate
CAS 376625-03-5C21H25NO2
1-[4-(4-Ethylphenyl)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethanone chemical structure, C22H27NO, CAS 30389-40-3
1-[4-(4-Ethylphenyl)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethanone
CAS 30389-40-3C22H27NO
1-(2,2,4-Trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)hexan-1-one chemical structure, C24H31NO, CAS 84816-98-8
1-(2,2,4-Trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)hexan-1-one
CAS 84816-98-8C24H31NO
2,2,4-Trimethyl-4-phenyl-3H-quinoline-1-carbaldehyde chemical structure, C19H21NO, CAS 296271-89-1
2,2,4-Trimethyl-4-phenyl-3H-quinoline-1-carbaldehyde
CAS 296271-89-1C19H21NO
1-[2,2,4-Trimethyl-4-(4-methylphenyl)-3,4-dihydroquinolin-1(2H)-yl]prop-2-en-1-one chemical structure, C22H25NO, CAS 300394-04-1
1-[2,2,4-Trimethyl-4-(4-methylphenyl)-3,4-dihydroquinolin-1(2H)-yl]prop-2-en-1-one
CAS 300394-04-1C22H25NO
Ethyl oxo(2,2,4,6-tetramethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)acetate chemical structure, C23H27NO3, CAS 351223-91-1
Ethyl oxo(2,2,4,6-tetramethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)acetate
CAS 351223-91-1C23H27NO3
N-Ethyl-2,2,4-trimethyl-4-phenyl-3H-quinoline-1-carboxamide chemical structure, C21H26N2O, CAS 364737-30-4
N-Ethyl-2,2,4-trimethyl-4-phenyl-3H-quinoline-1-carboxamide
CAS 364737-30-4C21H26N2O
2-[4-(4-Chlorophenyl)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]-2-oxoethyl thiocyanate chemical structure, C21H21ClN2OS, CAS 352659-71-3
2-[4-(4-Chlorophenyl)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]-2-oxoethyl thiocyanate
CAS 352659-71-3C21H21ClN2OS
2-Chloro-1-(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)ethanone chemical structure, C20H22ClNO, CAS 13671-85-7
2-Chloro-1-(2,2,4-trimethyl-4-phenyl-3,4-dihydroquinolin-1(2H)-yl)ethanone
CAS 13671-85-7C20H22ClNO