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Murcko scaffold

3,4-Dihydroisoquinolin-1(2H)-one scaffold

596 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
11
Chemicals
596
With full pages
69
Scaffold SMILES

O=C1NCCc2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 3,4-Dihydroisoquinolin-1(2H)-one page
Murcko scaffold O=C1NCCc2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 596 chemicals

3,4-Dihydroisoquinoline-1,4,7,8-tetrol--hydrogen chloride (1/1) chemical structure, C9H10ClNO4, CAS 101670-58-0
3,4-Dihydroisoquinoline-1,4,7,8-tetrol--hydrogen chloride (1/1)
CAS 101670-58-0C9H10ClNO4
3,4-Dihydro-7-hydroxy-6-methoxy-2-methyl-1(2H)-isoquinolinone chemical structure, C11H13NO3, CAS 21796-15-6
3,4-Dihydro-7-hydroxy-6-methoxy-2-methyl-1(2H)-isoquinolinone
CAS 21796-15-6C11H13NO3
3,4-Dihydro-5-methyl-1(2H)-isoquinolinone chemical structure, C10H11NO, CAS 129075-56-5
3,4-Dihydro-5-methyl-1(2H)-isoquinolinone
CAS 129075-56-5C10H11NO
3,4-Dihydroisoquinolin-1(2H)-one chemical structure, C9H9NO, CAS 1196-38-9
3,4-Dihydroisoquinolin-1(2H)-one
CAS 1196-38-9C9H9NO
2-Amino-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C9H10N2O, CAS 39113-01-4
2-Amino-3,4-dihydroisoquinolin-1(2H)-one
CAS 39113-01-4C9H10N2O
N-Methylcorydaldine chemical structure, C12H15NO3, CAS 6514-05-2
N-Methylcorydaldine
CAS 6514-05-2C12H15NO3
Corydaldine chemical structure, C11H13NO3, CAS 493-49-2
Corydaldine
CAS 493-49-2C11H13NO3
RefChem:381527 chemical structure, C11H13NO, CAS 26278-65-9
RefChem:381527
CAS 26278-65-9C11H13NO
3,3-Diethyl-3,4-dihydro-1(2H)-isoquinolinone chemical structure, C13H17NO, CAS 26278-66-0
3,3-Diethyl-3,4-dihydro-1(2H)-isoquinolinone
CAS 26278-66-0C13H17NO
(3S)-3-Methyl-3,4-dihydro-2H-isoquinolin-1-one chemical structure, C10H11NO, CAS 24292-48-6
(3S)-3-Methyl-3,4-dihydro-2H-isoquinolin-1-one
CAS 24292-48-6C10H11NO
6,7-Dimethoxy-3,3-dimethyl-2,4-dihydroisoquinolin-1-one chemical structure, C13H17NO3, CAS 331244-81-6
6,7-Dimethoxy-3,3-dimethyl-2,4-dihydroisoquinolin-1-one
CAS 331244-81-6C13H17NO3
3,3,6,7-Tetramethyl-2,4-dihydroisoquinolin-1-one chemical structure, C13H17NO, CAS 312732-73-3
3,3,6,7-Tetramethyl-2,4-dihydroisoquinolin-1-one
CAS 312732-73-3C13H17NO
(R)-1-Oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid chemical structure, C10H9NO3, CAS 104974-47-2
(R)-1-Oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
CAS 104974-47-2C10H9NO3
3-Methyl-3,4-dihydroisoquinolin-1(2H)-one chemical structure, C10H11NO, CAS 35690-67-6
3-Methyl-3,4-dihydroisoquinolin-1(2H)-one
CAS 35690-67-6C10H11NO
3,3-Dimethyl-7-(methylethyl)-2,3,4-trihydroisoquinolin-1-one chemical structure, C14H19NO, CAS 394652-72-3
3,3-Dimethyl-7-(methylethyl)-2,3,4-trihydroisoquinolin-1-one
CAS 394652-72-3C14H19NO
3,3,5,8-Tetramethyl-2,4-dihydroisoquinolin-1-one chemical structure, C13H17NO, CAS 682347-37-1
3,3,5,8-Tetramethyl-2,4-dihydroisoquinolin-1-one
CAS 682347-37-1C13H17NO
3-Ethyl-3-methyl-2,4-dihydroisoquinolin-1-one chemical structure, C12H15NO, CAS 313661-16-4
3-Ethyl-3-methyl-2,4-dihydroisoquinolin-1-one
CAS 313661-16-4C12H15NO
N-(6,7-Dimethoxy-1-oxo-1,2,3,4-tetrahydro-4-isoquinolinyl)-2,2,2-trifluoroacetamide chemical structure, C13H13F3N2O4, CAS 685109-21-1
N-(6,7-Dimethoxy-1-oxo-1,2,3,4-tetrahydro-4-isoquinolinyl)-2,2,2-trifluoroacetamide
CAS 685109-21-1C13H13F3N2O4
2-Ethyl-1,2,3,4-tetrahydroisoquinolin-1-one chemical structure, C11H13NO, CAS 82481-09-2
2-Ethyl-1,2,3,4-tetrahydroisoquinolin-1-one
CAS 82481-09-2C11H13NO
1-Oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid chemical structure, C10H9NO3, CAS 63586-82-3
1-Oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
CAS 63586-82-3C10H9NO3
2-Methyl-1,2,3,4-tetrahydroisoquinolin-1-one chemical structure, C10H11NO, CAS 6772-65-2
2-Methyl-1,2,3,4-tetrahydroisoquinolin-1-one
CAS 6772-65-2C10H11NO
(S)-1-Oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid chemical structure, C10H9NO3, CAS 99266-00-9
(S)-1-Oxo-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
CAS 99266-00-9C10H9NO3
1(2H)-Isoquinolinone, 3,4-dihydro-3-methyl-, (R)- chemical structure, C10H11NO, CAS 61768-98-7
1(2H)-Isoquinolinone, 3,4-dihydro-3-methyl-, (R)-
CAS 61768-98-7C10H11NO
(3S)-3-Ethyl-3-methyl-2,4-dihydroisoquinolin-1-one chemical structure, C12H15NO, CAS 2243982-02-5
(3S)-3-Ethyl-3-methyl-2,4-dihydroisoquinolin-1-one
CAS 2243982-02-5C12H15NO