Murcko scaffold
Ring system with 4 rings and 24 atoms
40 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 24
- Chemicals
- 40
- With full pages
- 1
Scaffold SMILES
O=C(Nc1ccccc1)c1cc2ccc(-c3ccncc3)nc2s1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 40 of 40 chemicals
![3-Amino-N-(3-chloro-4-methylphenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide chemical structure, C20H15ClN4OS, CAS 625370-61-8](/s/RQWIMVJTVIQPJK-UHFFFAOYSA-N.svg)
3-Amino-N-(3-chloro-4-methylphenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide
CAS 625370-61-8C20H15ClN4OS
![3-Amino-N-(2-chloro-5-methoxyphenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C20H15ClN4O2S, CAS 625370-63-0](/s/HJUIWBOSBMSRTC-UHFFFAOYSA-N.svg)
3-Amino-N-(2-chloro-5-methoxyphenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide
CAS 625370-63-0C20H15ClN4O2S
![3-Amino-N-(4-bromo-2-methylphenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide chemical structure, C20H15BrN4OS, CAS 499209-67-5](/s/HHMAWXUGYHGYRC-UHFFFAOYSA-N.svg)
3-Amino-N-(4-bromo-2-methylphenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide
CAS 499209-67-5C20H15BrN4OS
![3-Amino-N-(4-bromo-3-methylphenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C20H15BrN4OS, CAS 445267-33-4](/s/LOLJECNXHBPUHS-UHFFFAOYSA-N.svg)
3-Amino-N-(4-bromo-3-methylphenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide
CAS 445267-33-4C20H15BrN4OS
![3-Amino-N-(5-chloro-2-methoxyphenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C20H15ClN4O2S, CAS 445267-38-9](/s/JNSBSJXJOQUPDX-UHFFFAOYSA-N.svg)
3-Amino-N-(5-chloro-2-methoxyphenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide
CAS 445267-38-9C20H15ClN4O2S
![3-Amino-N-(4-bromo-2-fluorophenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide chemical structure, C19H12BrFN4OS, CAS 625370-65-2](/s/CPFMWSVNIVLLIQ-UHFFFAOYSA-N.svg)
3-Amino-N-(4-bromo-2-fluorophenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide
CAS 625370-65-2C19H12BrFN4OS
![3-Amino-N-[2-methoxy-5-(trifluoromethyl)phenyl]-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide chemical structure, C21H15F3N4O2S, CAS 625370-66-3](/s/YXKJVDYQBOFZMR-UHFFFAOYSA-N.svg)
3-Amino-N-[2-methoxy-5-(trifluoromethyl)phenyl]-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide
CAS 625370-66-3C21H15F3N4O2S
![3-Amino-N-[2-chloro-5-(trifluoromethyl)phenyl]-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide chemical structure, C20H12ClF3N4OS, CAS 445267-43-6](/s/APBBJNQXSZYMCY-UHFFFAOYSA-N.svg)
3-Amino-N-[2-chloro-5-(trifluoromethyl)phenyl]-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide
CAS 445267-43-6C20H12ClF3N4OS
![3-Amino-N-(5-chloro-2-methylphenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide chemical structure, C20H15ClN4OS, CAS 625370-62-9](/s/NYFIAMZVHSIJLX-UHFFFAOYSA-N.svg)
3-Amino-N-(5-chloro-2-methylphenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide
CAS 625370-62-9C20H15ClN4OS
![3-Amino-N-(3,5-dichlorophenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C19H12Cl2N4OS, CAS 445267-47-0](/s/COAPWMGOQUPWPZ-UHFFFAOYSA-N.svg)
3-Amino-N-(3,5-dichlorophenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide
CAS 445267-47-0C19H12Cl2N4OS
![3-Amino-6-(pyridin-4-yl)-N-(3,4,5-trimethoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C22H20N4O4S, CAS 445267-51-6](/s/SQHJDAVFCVMSCG-UHFFFAOYSA-N.svg)
3-Amino-6-(pyridin-4-yl)-N-(3,4,5-trimethoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 445267-51-6C22H20N4O4S
![3-Amino-N-[2-(isobutylsulfanyl)phenyl]-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C23H22N4OS2, CAS 445267-56-1](/s/XXUWPVWAYWYMQT-UHFFFAOYSA-N.svg)
3-Amino-N-[2-(isobutylsulfanyl)phenyl]-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 445267-56-1C23H22N4OS2
![3-Amino-N-(4-methylphenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide chemical structure, C20H16N4OS, CAS 496019-23-9](/s/FXGRIHXUIMOIJL-UHFFFAOYSA-N.svg)
3-Amino-N-(4-methylphenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide
CAS 496019-23-9C20H16N4OS
![3-Amino-N-(3,4-dimethoxyphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C21H18N4O3S, CAS 496019-31-9](/s/DUVCUHNWXIAIOE-UHFFFAOYSA-N.svg)
3-Amino-N-(3,4-dimethoxyphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 496019-31-9C21H18N4O3S
![3-Amino-N-(4-methoxy-2-methylphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C21H18N4O2S, CAS 496801-86-6](/s/BPODWHBDPRSZHG-UHFFFAOYSA-N.svg)
3-Amino-N-(4-methoxy-2-methylphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 496801-86-6C21H18N4O2S
![N-(4-Acetylphenyl)-3-amino-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C21H16N4O2S, CAS 496802-09-6](/s/IUEYUBBRCXDKCZ-UHFFFAOYSA-N.svg)
N-(4-Acetylphenyl)-3-amino-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 496802-09-6C21H16N4O2S
![3-Amino-N-(4-fluorophenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C19H13FN4OS, CAS 496801-80-0](/s/KNSGMAOXEWVZHR-UHFFFAOYSA-N.svg)
3-Amino-N-(4-fluorophenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide
CAS 496801-80-0C19H13FN4OS
![3-Amino-N-(3,4-difluorophenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide chemical structure, C19H12F2N4OS, CAS 496019-26-2](/s/WDLFLFHJALLNTM-UHFFFAOYSA-N.svg)
3-Amino-N-(3,4-difluorophenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide
CAS 496019-26-2C19H12F2N4OS
![3-Amino-N-(5-fluoro-2-methylphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C20H15FN4OS, CAS 445267-49-2](/s/GCCYWCSNEPJGOD-UHFFFAOYSA-N.svg)
3-Amino-N-(5-fluoro-2-methylphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 445267-49-2C20H15FN4OS
![3-Amino-N-(3-fluorophenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide chemical structure, C19H13FN4OS, CAS 489398-43-8](/s/HJLDBMSHFZDKJT-UHFFFAOYSA-N.svg)
3-Amino-N-(3-fluorophenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide
CAS 489398-43-8C19H13FN4OS
![3-Amino-N-(2,5-dichlorophenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C19H12Cl2N4OS, CAS 445267-30-1](/s/KSTDOMUUPQPTOT-UHFFFAOYSA-N.svg)
3-Amino-N-(2,5-dichlorophenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 445267-30-1C19H12Cl2N4OS
![3-Amino-N-(2,6-dichlorophenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide chemical structure, C19H12Cl2N4OS, CAS 626219-52-1](/s/CKLRRAVUCLWYDU-UHFFFAOYSA-N.svg)
3-Amino-N-(2,6-dichlorophenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide
CAS 626219-52-1C19H12Cl2N4OS
![3-Amino-N-(2,5-dimethylphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C21H18N4OS, CAS 496019-12-6](/s/KOPYJLUBRCVGLH-UHFFFAOYSA-N.svg)
3-Amino-N-(2,5-dimethylphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 496019-12-6C21H18N4OS
![3-Amino-N-(2,5-dimethoxyphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C21H18N4O3S, CAS 496019-15-9](/s/BQIMMKYKSLRJLD-UHFFFAOYSA-N.svg)
3-Amino-N-(2,5-dimethoxyphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 496019-15-9C21H18N4O3S
- 3-Amino-N-(3-bromophenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide445267-35-6C19H13BrN4OS
- 3-Amino-N-(2,4-dimethylphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide496019-24-0C21H18N4OS
- 3-Amino-6-(4-pyridinyl)-N-[2-(trifluoromethyl)phenyl]thieno[2,3-b]pyridine-2-carboxamide496019-29-5C20H13F3N4OS
- 3-Amino-N-[4-chloro-3-(trifluoromethyl)phenyl]-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide496019-30-8C20H12ClF3N4OS
- 3-Amino-N-(2-methoxyphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide496800-98-7C20H16N4O2S
- 3-Amino-N-(3-methoxyphenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide496801-04-8C20H16N4O2S
- 3-Amino-N-(2,4-difluorophenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide445267-45-8C19H12F2N4OS
- 3-Amino-N-[2-(propylsulfanyl)phenyl]-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide445267-58-3C22H20N4OS2
- 3-Amino-N-(2-butylsulfanylphenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide445267-59-4C23H22N4OS2
- 3-Amino-6-(4-pyridinyl)-N-[3-(trifluoromethyl)phenyl]thieno[2,3-b]pyridine-2-carboxamide387830-93-5C20H13F3N4OS
- 3-Amino-N-(3-bromo-4-methylphenyl)-6-(pyridin-4-yl)thieno[2,3-b]pyridine-2-carboxamide626226-18-4C20H15BrN4OS
- 3-Amino-N-(3-fluoro-4-methylphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide445267-37-8C20H15FN4OS
- 3-Amino-N-(3-chlorophenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide496801-20-8C19H13ClN4OS
- 3-Amino-N-(2-ethylsulfanylphenyl)-6-pyridin-4-ylthieno[2,3-b]pyridine-2-carboxamide445267-57-2C21H18N4OS2
- 3-Amino-N-(2-ethoxyphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide496019-13-7C21H18N4O2S
- 3-Amino-N-(3-methylphenyl)-6-(4-pyridinyl)thieno[2,3-b]pyridine-2-carboxamide496019-18-2C20H16N4OS
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(Nc1ccccc1)c1cc2ccc(-c3ccccc3)nc2s121 chemicals
O=C(Nc1ccccc1)c1cc2nc(-c3ccccc3)ccn2n14 chemicals![Scaffold O=c1cc(-c2ccccc2)nc2nc(SCc3ccccc3)[nH]n12](/scaffold/DCGVEJDPJGVQTN-UHFFFAOYSA-N/structure.svg)
O=c1cc(-c2ccccc2)nc2nc(SCc3ccccc3)[nH]n121 chemical
O=C(Nc1ccccc1)c1cc2ccc(-c3cccnc3)nc2s11 chemical
O=c1c(-c2ccccc2)nnc2sc(COc3ccccc3)nn121 chemical![Scaffold O=C(OC1CCCCC1)c1cc2c([nH]1)CC(c1ccccc1)CC2=O](/scaffold/UEORQJXZNPNACU-UHFFFAOYSA-N/structure.svg)
O=C(OC1CCCCC1)c1cc2c([nH]1)CC(c1ccccc1)CC2=O1 chemical