Murcko scaffold
Ring system with 4 rings and 24 atoms
87 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 24
- Chemicals
- 87
- With full pages
- 4
Scaffold SMILES
O=C(Nc1ccccc1)c1cc2nc(-c3ccccc3)ccn2n1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 87 chemicals
![N-(3-Hydroxyphenyl)-7-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C20H16N4O2, CAS 312634-95-0](/s/NUPGBBOOIBGQDL-UHFFFAOYSA-N.svg)
N-(3-Hydroxyphenyl)-7-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 312634-95-0C20H16N4O2
![5-(3,4-Dimethylphenyl)-N-(2-ethylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C24H21F3N4O, CAS 438218-72-5](/s/QCRXYQDJOQKLRQ-UHFFFAOYSA-N.svg)
5-(3,4-Dimethylphenyl)-N-(2-ethylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 438218-72-5C24H21F3N4O
![5-(3,4-Dimethylphenyl)-N-(2-ethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C24H21F3N4O2, CAS 438219-21-7](/s/JJTZXULXPCUPLD-UHFFFAOYSA-N.svg)
5-(3,4-Dimethylphenyl)-N-(2-ethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 438219-21-7C24H21F3N4O2
![N-(4-Chlorophenyl)-7-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C20H15ClN4O, CAS 312634-73-4](/s/BJBMWRCQMCYTTK-UHFFFAOYSA-N.svg)
N-(4-Chlorophenyl)-7-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 312634-73-4C20H15ClN4O
![N-(2-Ethylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C22H17F3N4O, CAS 313986-55-9](/s/KISQMJWPJIPKRO-UHFFFAOYSA-N.svg)
N-(2-Ethylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 313986-55-9C22H17F3N4O
![N-(3-Chloro-2-methylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C21H14ClF3N4O, CAS 312634-11-0](/s/QXVPKVAONRMBAZ-UHFFFAOYSA-N.svg)
N-(3-Chloro-2-methylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 312634-11-0C21H14ClF3N4O
![Methyl 2-[[5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]benzoate chemical structure, C22H15F3N4O3, CAS 5672-09-3](/s/OQYUWTAJTMLDLB-UHFFFAOYSA-N.svg)
Methyl 2-[[5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]benzoate
CAS 5672-09-3C22H15F3N4O3
![5-(4-Methylphenyl)-7-(trifluoromethyl)-N-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C24H21F3N4O4, CAS 334500-30-0](/s/FQGLHPVFWVHMBN-UHFFFAOYSA-N.svg)
5-(4-Methylphenyl)-7-(trifluoromethyl)-N-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 334500-30-0C24H21F3N4O4
![5-(4-Chlorophenyl)-N-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C22H16ClF3N4O3, CAS 312952-86-6](/s/GLHOATKNNJQVKI-UHFFFAOYSA-N.svg)
5-(4-Chlorophenyl)-N-(3,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 312952-86-6C22H16ClF3N4O3
![N-(3,4-Dichlorophenyl)-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C21H13Cl2F3N4O2, CAS 292058-03-8](/s/DSAZIGIRPWBRQN-UHFFFAOYSA-N.svg)
N-(3,4-Dichlorophenyl)-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 292058-03-8C21H13Cl2F3N4O2
![5-(4-Methoxyphenyl)-N-[2-(methylsulfanyl)phenyl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C22H17F3N4O2S, CAS 333761-58-3](/s/IUYOGCYCHRHNOP-UHFFFAOYSA-N.svg)
5-(4-Methoxyphenyl)-N-[2-(methylsulfanyl)phenyl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 333761-58-3C22H17F3N4O2S
![N-(3-Methoxy-5-nitrophenyl)-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C22H16F3N5O5, CAS 313245-64-6](/s/DLCVRNYCZZDHFD-UHFFFAOYSA-N.svg)
N-(3-Methoxy-5-nitrophenyl)-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 313245-64-6C22H16F3N5O5
![3-Bromo-N-(3,4-dimethylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C22H16BrF3N4O, CAS 314048-77-6](/s/NSOXONDNBDVOTH-UHFFFAOYSA-N.svg)
3-Bromo-N-(3,4-dimethylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 314048-77-6C22H16BrF3N4O
![3-Bromo-N-(2-hydroxy-5-methylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C21H14BrF3N4O2, CAS 313986-91-3](/s/CPJDXDIKRCACAV-UHFFFAOYSA-N.svg)
3-Bromo-N-(2-hydroxy-5-methylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 313986-91-3C21H14BrF3N4O2
![3-Bromo-N-(3-chloro-2-methylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C21H13BrClF3N4O, CAS 331424-22-7](/s/CLMGUOLUYMHBCE-UHFFFAOYSA-N.svg)
3-Bromo-N-(3-chloro-2-methylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 331424-22-7C21H13BrClF3N4O
![3-Bromo-N-(2-bromophenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C20H11Br2F3N4O, CAS 314048-84-5](/s/ZHKVPUALQKETTA-UHFFFAOYSA-N.svg)
3-Bromo-N-(2-bromophenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 314048-84-5C20H11Br2F3N4O
![3-Bromo-N-(3-hydroxyphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C20H12BrF3N4O2, CAS 314048-86-7](/s/RORSRTBXSGEHFJ-UHFFFAOYSA-N.svg)
3-Bromo-N-(3-hydroxyphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 314048-86-7C20H12BrF3N4O2
![3-Chloro-N-(3,4-dimethoxyphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C22H16ClF3N4O3, CAS 313987-40-5](/s/NYVLFWNEDACJBV-UHFFFAOYSA-N.svg)
3-Chloro-N-(3,4-dimethoxyphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 313987-40-5C22H16ClF3N4O3
![3-Chloro-N-(2-methylsulfanylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C21H14ClF3N4OS, CAS 313987-43-8](/s/GNCUWPLCRGSGBB-UHFFFAOYSA-N.svg)
3-Chloro-N-(2-methylsulfanylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 313987-43-8C21H14ClF3N4OS
![3-Bromo-N-(5-chloro-2-methoxyphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C21H13BrClF3N4O2, CAS 314049-08-6](/s/VFLWZLMJFXEHMT-UHFFFAOYSA-N.svg)
3-Bromo-N-(5-chloro-2-methoxyphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 314049-08-6C21H13BrClF3N4O2
![3-Chloro-N-(4-cyanophenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C21H11ClF3N5O, CAS 313986-77-5](/s/BKORDFSRCDPVPG-UHFFFAOYSA-N.svg)
3-Chloro-N-(4-cyanophenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 313986-77-5C21H11ClF3N5O
![N-(2,4-Dimethoxyphenyl)-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C23H19F3N4O4, CAS 292057-94-4](/s/ILSWXRQBBQPEFX-UHFFFAOYSA-N.svg)
N-(2,4-Dimethoxyphenyl)-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 292057-94-4C23H19F3N4O4
![N-(3-Hydroxyphenyl)-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C21H15F3N4O3, CAS 313986-49-1](/s/NTVPNMFKAGPNSP-UHFFFAOYSA-N.svg)
N-(3-Hydroxyphenyl)-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 313986-49-1C21H15F3N4O3
![5-(4-Methoxyphenyl)-7-(trifluoromethyl)-N-[2-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-2-carboxamide chemical structure, C22H14F6N4O2, CAS 312634-02-9](/s/QDXWJWCRBPSBDY-UHFFFAOYSA-N.svg)
5-(4-Methoxyphenyl)-7-(trifluoromethyl)-N-[2-(trifluoromethyl)phenyl]pyrazolo[1,5-a]pyrimidine-2-carboxamide
CAS 312634-02-9C22H14F6N4O2
- 3-Bromo-N-(3-methoxy-5-nitrophenyl)-5-(4-methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide299406-78-3C22H15BrF3N5O5
- N-(3,4-Dimethylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide313986-57-1C22H17F3N4O
- N-(3-Chloro-4-fluorophenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide314048-58-3C20H11ClF4N4O
- N-(2,4-Dimethoxyphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide314048-59-4C22H17F3N4O3
- Methyl 2-[[3-chloro-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carbonyl]amino]benzoate313986-76-4C22H14ClF3N4O3
- 3-Bromo-N-(4-ethylphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide313986-94-6C22H16BrF3N4O
- N-(3,4-Dimethoxyphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide313987-28-9C22H17F3N4O3
- 3-Bromo-N-(3,4-dimethoxyphenyl)-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide313987-52-9C22H16BrF3N4O3
- 3-Bromo-N-[2-(methylsulfanyl)phenyl]-5-phenyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide313387-30-3C21H14BrF3N4OS
- Methyl 2-[(7-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-2-carbonyl)amino]benzoate312634-83-6C22H18N4O3
- N-(2,4-Dimethoxyphenyl)-7-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-2-carboxamide312634-91-6C22H20N4O3
- N-(5-Chloro-2-methoxyphenyl)-7-methyl-5-phenylpyrazolo[1,5-a]pyrimidine-2-carboxamide312635-02-2C21H17ClN4O2
- 5-(4-Fluorophenyl)-N-(2-hydroxy-5-methylphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide5846-72-0C21H14F4N4O2
- N-(2,4-Dimethoxyphenyl)-5-(4-fluorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide313248-05-4C22H16F4N4O3
- N,5-bis(3,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide333761-20-9C24H21F3N4O5
- 5-(4-Bromophenyl)-N-(4-chlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide333763-07-8C20H11BrClF3N4O
- N-(4-Acetylphenyl)-5-(4-bromophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide329078-41-3C22H14BrF3N4O2
- 5-(4-Bromophenyl)-N-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide333763-23-8C22H16BrF3N4O3
- N-(4-Acetylphenyl)-5-(4-bromophenyl)-3-chloro-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide333764-39-9C22H13BrClF3N4O2
- 5-(4-Bromophenyl)-3-chloro-N-(2,4-dimethoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide333764-46-8C22H15BrClF3N4O3
- 5-(4-Bromophenyl)-3-chloro-N-(3-methoxy-5-nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide333764-83-3C21H12BrClF3N5O4
- N-(2,3-Dichlorophenyl)-5-(4-nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide333765-19-8C20H10Cl2F3N5O3
- N-(4-Acetylphenyl)-5-(4-nitrophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide333765-20-1C22H14F3N5O4
- 5-(4-Nitrophenyl)-7-(trifluoromethyl)-N-(3,4,5-trimethoxyphenyl)pyrazolo[1,5-a]pyrimidine-2-carboxamide333765-40-5C23H18F3N5O6
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=c1cc(-c2ccccc2)nc2nc(SCc3ccccc3)[nH]n12](/scaffold/DCGVEJDPJGVQTN-UHFFFAOYSA-N/structure.svg)
![Scaffold O=C(OC1CCCCC1)c1cc2c([nH]1)CC(c1ccccc1)CC2=O](/scaffold/UEORQJXZNPNACU-UHFFFAOYSA-N/structure.svg)
