Murcko scaffold
Ring system with 4 rings and 24 atoms
87 chemicals on CompoundList share this ring system.
- Rings
- 4
- Scaffold atoms
- 24
- Chemicals
- 87
- With full pages
- 21
Scaffold SMILES
O=C(Nc1ccccc1)c1cc2ccc(-c3ccccc3)nc2s1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 87 chemicals
![3-Amino-N-(4-fluorophenyl)-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C21H13F4N3OS, CAS 313379-66-7](/s/GMVMCVQFXFKCGB-UHFFFAOYSA-N.svg)
3-Amino-N-(4-fluorophenyl)-6-phenyl-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 313379-66-7C21H13F4N3OS
![3-Amino-N-(3-fluorophenyl)-6-(4-fluorophenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C20H13F2N3OS, CAS 488707-77-3](/s/ILTICXNZVNCHAO-UHFFFAOYSA-N.svg)
3-Amino-N-(3-fluorophenyl)-6-(4-fluorophenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 488707-77-3C20H13F2N3OS
![3-Amino-6-(3,4-dimethoxyphenyl)-N-(4-fluorophenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C22H18FN3O3S, CAS 500145-09-5](/s/HFEPZSGHHMBWEX-UHFFFAOYSA-N.svg)
3-Amino-6-(3,4-dimethoxyphenyl)-N-(4-fluorophenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 500145-09-5C22H18FN3O3S
![3-Amino-N-(3-chloro-2-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C22H18ClN3O2S, CAS 625369-57-5](/s/LJLLEEUHTVGFFK-UHFFFAOYSA-N.svg)
3-Amino-N-(3-chloro-2-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 625369-57-5C22H18ClN3O2S
![3-Amino-N-(3-chloro-4-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C22H18ClN3O2S, CAS 497241-36-8](/s/IZIHSIYNPLSLMR-UHFFFAOYSA-N.svg)
3-Amino-N-(3-chloro-4-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 497241-36-8C22H18ClN3O2S
![3-Amino-N-(2,4-dichlorophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C21H15Cl2N3O2S, CAS 384366-90-9](/s/YUORNWWBBIDWOX-UHFFFAOYSA-N.svg)
3-Amino-N-(2,4-dichlorophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 384366-90-9C21H15Cl2N3O2S
![3-Amino-N-(3,4-dimethylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C23H21N3O2S, CAS 384366-95-4](/s/UHBPZGWCSBHTSR-UHFFFAOYSA-N.svg)
3-Amino-N-(3,4-dimethylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 384366-95-4C23H21N3O2S
![3-Amino-6-(3-methoxyphenyl)-N-(3-methylphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C22H19N3O2S, CAS 371201-68-2](/s/DQWJUCYBTZTSOE-UHFFFAOYSA-N.svg)
3-Amino-6-(3-methoxyphenyl)-N-(3-methylphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 371201-68-2C22H19N3O2S
![3-Amino-N-(2-chloro-5-methoxyphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C22H18ClN3O3S, CAS 488803-83-4](/s/PPTSTPSVZDAHLP-UHFFFAOYSA-N.svg)
3-Amino-N-(2-chloro-5-methoxyphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 488803-83-4C22H18ClN3O3S
![3-Amino-N-(4-bromo-2-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C22H18BrN3O2S, CAS 445267-68-5](/s/AKVFWNJXTQNZMS-UHFFFAOYSA-N.svg)
3-Amino-N-(4-bromo-2-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 445267-68-5C22H18BrN3O2S
![3-Amino-N-(4-bromo-3-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C22H18BrN3O2S, CAS 445267-69-6](/s/UQAUBEAYIIUOKT-UHFFFAOYSA-N.svg)
3-Amino-N-(4-bromo-3-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 445267-69-6C22H18BrN3O2S
![3-Amino-N-(3-bromophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C21H16BrN3O2S, CAS 371116-47-1](/s/KAQIURIWTTVBIA-UHFFFAOYSA-N.svg)
3-Amino-N-(3-bromophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 371116-47-1C21H16BrN3O2S
![3-Amino-N-(4-fluoro-2-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C22H18FN3O2S, CAS 625369-58-6](/s/MYOBNZGBHSSQIO-UHFFFAOYSA-N.svg)
3-Amino-N-(4-fluoro-2-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 625369-58-6C22H18FN3O2S
![3-Amino-N-(3-fluoro-4-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C22H18FN3O2S, CAS 445267-72-1](/s/OLVKCMZBCLYBDW-UHFFFAOYSA-N.svg)
3-Amino-N-(3-fluoro-4-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 445267-72-1C22H18FN3O2S
![3-Amino-6-(3-methoxyphenyl)-N-(4-methylphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C22H19N3O2S, CAS 384794-54-1](/s/MNMZKIBCOAFFJY-UHFFFAOYSA-N.svg)
3-Amino-6-(3-methoxyphenyl)-N-(4-methylphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 384794-54-1C22H19N3O2S
![3-Amino-N-(2,4-dimethylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C23H21N3O2S, CAS 384800-88-8](/s/UTCOWBTURZNOOZ-UHFFFAOYSA-N.svg)
3-Amino-N-(2,4-dimethylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 384800-88-8C23H21N3O2S
![3-Amino-N-(4-bromo-2-fluorophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C21H15BrFN3O2S, CAS 488093-18-1](/s/CHKXFNAAWFDEJA-UHFFFAOYSA-N.svg)
3-Amino-N-(4-bromo-2-fluorophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 488093-18-1C21H15BrFN3O2S
![3-Amino-N-(2-chloro-4-fluorophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C21H15ClFN3O2S, CAS 500272-71-9](/s/OQJLHHRXXWKEDT-UHFFFAOYSA-N.svg)
3-Amino-N-(2-chloro-4-fluorophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 500272-71-9C21H15ClFN3O2S
![3-Amino-6-(3-methoxyphenyl)-N-[2-methoxy-5-(trifluoromethyl)phenyl]thieno[2,3-b]pyridine-2-carboxamide chemical structure, C23H18F3N3O3S, CAS 488813-12-3](/s/CJQAINXKLCVTQA-UHFFFAOYSA-N.svg)
3-Amino-6-(3-methoxyphenyl)-N-[2-methoxy-5-(trifluoromethyl)phenyl]thieno[2,3-b]pyridine-2-carboxamide
CAS 488813-12-3C23H18F3N3O3S
![3-Amino-N-(3-bromo-4-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C22H18BrN3O2S, CAS 488111-50-8](/s/ORUWGTUUTIVMRQ-UHFFFAOYSA-N.svg)
3-Amino-N-(3-bromo-4-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 488111-50-8C22H18BrN3O2S
![3-Amino-6-(3-methoxyphenyl)-N-[2-(trifluoromethyl)phenyl]thieno[2,3-b]pyridine-2-carboxamide chemical structure, C22H16F3N3O2S, CAS 384793-54-8](/s/CQZHVGXGTODKOG-UHFFFAOYSA-N.svg)
3-Amino-6-(3-methoxyphenyl)-N-[2-(trifluoromethyl)phenyl]thieno[2,3-b]pyridine-2-carboxamide
CAS 384793-54-8C22H16F3N3O2S
![3-Amino-N-(2-bromophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C21H16BrN3O2S, CAS 445267-81-2](/s/WCEWOQLOICMHRN-UHFFFAOYSA-N.svg)
3-Amino-N-(2-bromophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 445267-81-2C21H16BrN3O2S
![3-Amino-N-(3-chlorophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C21H16ClN3O2S, CAS 371133-80-1](/s/IIBLJPLRMBFSAN-UHFFFAOYSA-N.svg)
3-Amino-N-(3-chlorophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 371133-80-1C21H16ClN3O2S
![3-Amino-N-(4-chlorophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide chemical structure, C21H16ClN3O2S, CAS 371131-63-4](/s/KBVITEQDLCOHJR-UHFFFAOYSA-N.svg)
3-Amino-N-(4-chlorophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide
CAS 371131-63-4C21H16ClN3O2S
- 3-Amino-N-(2,3-dimethylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide384373-45-9C23H21N3O2S
- 3-Amino-N-(3,5-dichlorophenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide445267-85-6C21H15Cl2N3O2S
- 3-Amino-N-(5-fluoro-2-methylphenyl)-6-(3-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide445267-87-8C22H18FN3O2S
- 3-Amino-6-(3-methoxyphenyl)-N-(4-methylsulfanylphenyl)thieno[2,3-b]pyridine-2-carboxamide625369-59-7C22H19N3O2S2
- 3-Amino-N-(4-bromophenyl)-6-(3,4-dimethoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide625370-30-1C22H18BrN3O3S
- 3-Amino-N-(3-chloro-2-methylphenyl)-6-(3,4-dimethoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide625369-92-8C23H20ClN3O3S
- 3-Amino-N-(2,5-dichlorophenyl)-6-(3,4-dimethoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide445268-06-4C22H17Cl2N3O3S
- 3-Amino-N-(2-bromo-4-methylphenyl)-6-(3,4-dimethoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide445268-09-7C23H20BrN3O3S
- 3-Amino-N-(4-bromo-3-methylphenyl)-6-(3,4-dimethoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide500269-28-3C23H20BrN3O3S
- 3-Amino-N-(4-bromophenyl)-6-(4-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide445268-16-6C21H16BrN3O2S
- 3-Amino-N-(2-ethoxyphenyl)-6-(4-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide445268-19-9C23H21N3O3S
- 3-Amino-N-(2-bromo-4-methylphenyl)-6-(4-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide445268-23-5C22H18BrN3O2S
- 3-Amino-N-(4-bromo-2-methylphenyl)-6-(4-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide445268-27-9C22H18BrN3O2S
- 3-Amino-N-(4-bromo-3-methylphenyl)-6-(4-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide445268-28-0C22H18BrN3O2S
- 3-Amino-N-(2-bromophenyl)-6-(4-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide445268-51-9C21H16BrN3O2S
- 3-Amino-N-(5-chloro-2-methylphenyl)-6-(4-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide445268-55-3C22H18ClN3O2S
- 3-Amino-N-(3,5-dichlorophenyl)-6-(4-methoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide445268-62-2C21H15Cl2N3O2S
- 3-Amino-N-(3-chloro-2-methylphenyl)-6-(4-fluorophenyl)thieno[2,3-b]pyridine-2-carboxamide625370-02-7C21H15ClFN3OS
- 3-Amino-6-(4-fluorophenyl)-N-[4-(trifluoromethyl)phenyl]thieno[2,3-b]pyridine-2-carboxamide625370-36-7C21H13F4N3OS
- 3-Amino-6-(4-fluorophenyl)-N-(4-methylsulfanylphenyl)thieno[2,3-b]pyridine-2-carboxamide625370-58-3C21H16FN3OS2
- 3-Amino-6-(4-fluorophenyl)-N-(3,4,5-trimethoxyphenyl)thieno[2,3-b]pyridine-2-carboxamide625370-60-7C23H20FN3O4S
- 3-Amino-N-(3,4-dimethoxyphenyl)-6-(4-methoxyphenyl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide487020-82-6C24H20F3N3O4S
- 3-Amino-6-(3,4-dimethoxyphenyl)-N-(4-fluorophenyl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide487037-03-6C23H17F4N3O3S
- 3-Amino-6-(3,4-dimethoxyphenyl)-N-(4-methoxyphenyl)-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide625369-54-2C24H20F3N3O4S
Related scaffolds
Same ring framework with different atoms or bond orders
![Scaffold O=c1cc(-c2ccccc2)nc2nc(SCc3ccccc3)[nH]n12](/scaffold/DCGVEJDPJGVQTN-UHFFFAOYSA-N/structure.svg)
![Scaffold O=C(OC1CCCCC1)c1cc2c([nH]1)CC(c1ccccc1)CC2=O](/scaffold/UEORQJXZNPNACU-UHFFFAOYSA-N/structure.svg)
