Murcko scaffold
Ring system with 3 rings and 19 atoms
43 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 19
- Chemicals
- 43
- With full pages
- 18
Scaffold SMILES
O=C(Cc1ccccc1)Nc1cc2c(s1)CNCC2
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 43 of 43 chemicals
![N-(3-Cyano-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-phenylacetamide chemical structure, C17H17N3OS, CAS 380659-66-5](/s/WFUZYBMJDGNMEA-UHFFFAOYSA-N.svg)
N-(3-Cyano-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-phenylacetamide
CAS 380659-66-5C17H17N3OS
![N-(3-Cyano-5,5,7,7-tetramethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-(4-methoxyphenyl)acetamide chemical structure, C21H25N3O2S, CAS 380553-25-3](/s/MHWYTHCBCAVBEP-UHFFFAOYSA-N.svg)
N-(3-Cyano-5,5,7,7-tetramethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-(4-methoxyphenyl)acetamide
CAS 380553-25-3C21H25N3O2S
![Diethyl 2-(2-(4-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate chemical structure, C22H26N2O6S, CAS 314043-08-8](/s/BDVUVFMGLFBTEO-UHFFFAOYSA-N.svg)
Diethyl 2-(2-(4-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-3,6(7H)-dicarboxylate
CAS 314043-08-8C22H26N2O6S
![Methyl 5,5,7,7-tetramethyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate chemical structure, C21H26N2O3S, CAS 887901-15-7](/s/FENJZXWEXBNMMV-UHFFFAOYSA-N.svg)
Methyl 5,5,7,7-tetramethyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
CAS 887901-15-7C21H26N2O3S
![Ethyl 3-cyano-2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate chemical structure, C19H19N3O3S, CAS 864927-14-0](/s/UNFHKLGKPIGWLY-UHFFFAOYSA-N.svg)
Ethyl 3-cyano-2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
CAS 864927-14-0C19H19N3O3S
![Ethyl 5,5,7,7-tetramethyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate chemical structure, C22H28N2O3S, CAS 887902-01-4](/s/VOZLLSCGNNOJSI-UHFFFAOYSA-N.svg)
Ethyl 5,5,7,7-tetramethyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
CAS 887902-01-4C22H28N2O3S
![6-Acetyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide chemical structure, C18H19N3O3S, CAS 864857-71-6](/s/VCGUYYMHXBKXDN-UHFFFAOYSA-N.svg)
6-Acetyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide
CAS 864857-71-6C18H19N3O3S
![Ethyl 6-acetyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate chemical structure, C20H22N2O4S, CAS 921091-23-8](/s/UZIDRLJEYSRQRB-UHFFFAOYSA-N.svg)
Ethyl 6-acetyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate
CAS 921091-23-8C20H22N2O4S
![Ethyl 3-carbamoyl-2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate chemical structure, C19H21N3O4S, CAS 864925-98-4](/s/QVTRIBMEFFAOMC-UHFFFAOYSA-N.svg)
Ethyl 3-carbamoyl-2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
CAS 864925-98-4C19H21N3O4S
![N-(6-Acetyl-3-cyano-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-2-phenylacetamide chemical structure, C18H17N3O2S, CAS 864859-11-0](/s/PTUAOTVLLMVTQF-UHFFFAOYSA-N.svg)
N-(6-Acetyl-3-cyano-5,7-dihydro-4H-thieno[2,3-c]pyridin-2-yl)-2-phenylacetamide
CAS 864859-11-0C18H17N3O2S
![Methyl 3-carbamoyl-2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate chemical structure, C18H19N3O4S, CAS 886953-57-7](/s/WFAGXKPVMUTQHU-UHFFFAOYSA-N.svg)
Methyl 3-carbamoyl-2-(2-phenylacetamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
CAS 886953-57-7C18H19N3O4S
![N-(6-Acetyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-(2,4-dimethylphenyl)acetamide chemical structure, C20H21N3O2S, CAS 900000-50-2](/s/VOXRZYOTJBTQCC-UHFFFAOYSA-N.svg)
N-(6-Acetyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-(2,4-dimethylphenyl)acetamide
CAS 900000-50-2C20H21N3O2S
![N-(6-Acetyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-(4-fluorophenyl)acetamide chemical structure, C18H16FN3O2S, CAS 900000-72-8](/s/UANDEHJFFUWYAT-UHFFFAOYSA-N.svg)
N-(6-Acetyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-(4-fluorophenyl)acetamide
CAS 900000-72-8C18H16FN3O2S
![6-Ethanoyl-2-[2-(4-fluorophenyl)ethanoylamino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide chemical structure, C18H18FN3O3S, CAS 899958-58-8](/s/UXFPBAKURIRZAD-UHFFFAOYSA-N.svg)
6-Ethanoyl-2-[2-(4-fluorophenyl)ethanoylamino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide
CAS 899958-58-8C18H18FN3O3S
![Ethyl 3-carbamoyl-2-(2-(4-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate chemical structure, C20H23N3O5S, CAS 923506-82-5](/s/AOPIWISLYCWTNS-UHFFFAOYSA-N.svg)
Ethyl 3-carbamoyl-2-(2-(4-methoxyphenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate
CAS 923506-82-5C20H23N3O5S
![Ethyl 6-methyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate hydrochloride chemical structure, C19H23ClN2O3S, CAS 1177696-58-0](/s/DHRPCMQEZWAIGH-UHFFFAOYSA-N.svg)
Ethyl 6-methyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate hydrochloride
CAS 1177696-58-0C19H23ClN2O3S
![Methyl 6-ethyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate hydrochloride chemical structure, C19H23ClN2O3S, CAS 1177804-87-3](/s/LQVAEVNFIVUNIM-UHFFFAOYSA-N.svg)
Methyl 6-ethyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate hydrochloride
CAS 1177804-87-3C19H23ClN2O3S
![N-(3-Cyano-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-phenylacetamide hydrochloride chemical structure, C17H18ClN3OS, CAS 1177870-63-1](/s/WHOPPDCRGIMQOO-UHFFFAOYSA-N.svg)
N-(3-Cyano-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-phenylacetamide hydrochloride
CAS 1177870-63-1C17H18ClN3OS
![N-[3-Cyano-6-(propan-2-yl)-4H,5H,6H,7H-thieno[2,3-c]pyridin-2-yl]-2-phenylacetamide hydrochloride chemical structure, C19H22ClN3OS, CAS 1177842-39-5](/s/MNAGPJCCJQGMOD-UHFFFAOYSA-N.svg)
N-[3-Cyano-6-(propan-2-yl)-4H,5H,6H,7H-thieno[2,3-c]pyridin-2-yl]-2-phenylacetamide hydrochloride
CAS 1177842-39-5C19H22ClN3OS
![2-(2-(4-Fluorophenyl)acetamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride chemical structure, C17H19ClFN3O2S, CAS 1177791-72-8](/s/GRWWJEHQMBTDBJ-UHFFFAOYSA-N.svg)
2-(2-(4-Fluorophenyl)acetamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
CAS 1177791-72-8C17H19ClFN3O2S
![2-(2-(4-Fluorophenyl)acetamido)-6-propyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride chemical structure, C19H23ClFN3O2S, CAS 1177863-96-5](/s/ZYTNSMGFNLKRAV-UHFFFAOYSA-N.svg)
2-(2-(4-Fluorophenyl)acetamido)-6-propyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
CAS 1177863-96-5C19H23ClFN3O2S
![6-Ethyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride chemical structure, C18H22ClN3O2S, CAS 1177575-54-0](/s/NKIJNHXKWHWTTH-UHFFFAOYSA-N.svg)
6-Ethyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
CAS 1177575-54-0C18H22ClN3O2S
![6-Methyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride chemical structure, C17H20ClN3O2S, CAS 1177824-72-4](/s/VMJNALUFJZYHRC-UHFFFAOYSA-N.svg)
6-Methyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
CAS 1177824-72-4C17H20ClN3O2S
![6-Isopropyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride chemical structure, C19H24ClN3O2S, CAS 1177833-88-3](/s/UBPOVHMICNQANF-UHFFFAOYSA-N.svg)
6-Isopropyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
CAS 1177833-88-3C19H24ClN3O2S
- 6-Acetyl-2-(2-(4-(methylthio)phenyl)acetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide942007-75-2C19H21N3O3S2
- N-(6-Acetyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-(4-(ethylthio)phenyl)acetamide919846-27-8C20H21N3O2S2
- N-(6-Acetyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-(4-(isopropylsulfonyl)phenyl)acetamide955620-50-5C21H23N3O4S2
- Ethyl 4,5,6,7-tetrahydro-6-methyl-2-[[2-[4-[(1-methylethyl)sulfonyl]phenyl]acetyl]amino]thieno[2,3-c]pyridine-3-carboxylate1171509-18-4C22H28N2O5S2
- 6-Acetyl-2-(2-(4-(ethylthio)phenyl)acetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide941971-38-6C20H23N3O3S2
- 6-Acetyl-2-(2-(4-(methylsulfonyl)phenyl)acetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide941930-85-4C19H21N3O5S2
- Methyl 2-(2-phenylacetamido)-6-(propan-2-yl)-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxylate hydrochloride1135212-09-7C20H25ClN2O3S
- Ethyl 6-ethyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate hydrochloride1135226-48-0C20H25ClN2O3S
- Ethyl 6-acetyl-2-(2-(4-(ethylthio)phenyl)acetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate919751-63-6C22H26N2O4S2
- N-(6-Acetyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-(4-(methylsulfonyl)phenyl)acetamide919851-47-1C19H19N3O4S2
- Ethyl 3-cyano-2-(2-(4-(methylsulfonyl)phenyl)acetamido)-4,5-dihydrothieno[2,3-c]pyridine-6(7H)-carboxylate919851-56-2C20H21N3O5S2
- 6-Acetyl-2-(2-(4-(ethylsulfonyl)phenyl)acetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide919858-34-7C20H23N3O5S2
- N-(6-Acetyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-(m-tolyl)acetamide1171838-64-4C19H19N3O2S
- Methyl 2-(2-(4-fluorophenyl)acetamido)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate hydrochloride1327401-68-2C20H24ClFN2O3S
- 2-(2-(4-Methoxyphenyl)acetamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride1327572-05-3C18H22ClN3O3S
- 2-(2-(2,4-Dimethylphenyl)acetamido)-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride1323399-51-4C19H24ClN3O2S
- Methyl 2-(2-(2,4-dimethylphenyl)acetamido)-6-propyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate hydrochloride1331250-62-4C22H29ClN2O3S
- N-(6-Acetyl-3-cyano-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)-2-chloro-2-phenylacetamide1365963-11-6C18H16ClN3O2S
- 6-Methyl-2-(2-(m-tolyl)acetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride1351589-33-7C18H22ClN3O2S
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(CN1C(=O)c2ccccc2C1=O)Nc1ccccc162 chemicals![Scaffold O=c1[nH]c(=O)c2[nH]c(NN=Cc3ccccc3)nc2[nH]1](/scaffold/CHHJWHRZURXTFZ-UHFFFAOYSA-N/structure.svg)
O=c1[nH]c(=O)c2[nH]c(NN=Cc3ccccc3)nc2[nH]135 chemicals
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O=C(Nc1ccccc1)Nc1nc2ccccc2s119 chemicals
C(=NNc1ccccc1)C1=Nc2ccccc2C115 chemicals
O=C(Cc1ccccc1)Nc1nc2ccccc2s115 chemicals![Scaffold O=c1[nH]c(=O)c2[nH]c(CNCc3ccccc3)nc2[nH]1](/scaffold/UVIPRNPUIHSMKT-UHFFFAOYSA-N/structure.svg)
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O=C(NCc1ccccc1)c1cc2ccccc2[nH]110 chemicals![Scaffold O=c1[nH]c(=O)c2[nH]c(NCCc3ccccc3)nc2[nH]1](/scaffold/SHGZCTVZCGSROM-UHFFFAOYSA-N/structure.svg)
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