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Murcko scaffold

Ring system with 3 rings and 19 atoms

18 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 18
With full pages: 4

Scaffold SMILES

O=C(NCc1ccccc1)c1csc2c1CCCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(NCc1ccccc1)c1csc2c1CCCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 18 of 18 chemicals

2-Amino-N-benzyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C16H18N2OS, CAS 312513-45-4

2-Amino-N-benzyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

CAS 312513-45-4C₁₆H₁₈N₂OS

N-Benzyl-2-(2-chloroacetamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C18H19ClN2O2S, CAS 851170-84-8

N-Benzyl-2-(2-chloroacetamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

CAS 851170-84-8C₁₈H₁₉ClN₂O₂S

6-tert-Butyl-N-(2-chlorobenzyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C20H24ClNOS, CAS 438229-33-5

6-tert-Butyl-N-(2-chlorobenzyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

CAS 438229-33-5C₂₀H₂₄ClNOS

2-Amino-N-benzyl-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C17H20N2OS, CAS 588678-91-5

2-Amino-N-benzyl-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

CAS 588678-91-5C₁₇H₂₀N₂OS

2-Amino-N-benzyl-6-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C20H26N2OS, CAS 588692-44-8

2-Amino-N-benzyl-6-tert-butyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

CAS 588692-44-8C₂₀H₂₆N₂OS

6-tert-Butyl-N-[1-(3,4-dimethoxyphenyl)ethyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C23H31NO3S, CAS 438225-35-5

6-tert-Butyl-N-[1-(3,4-dimethoxyphenyl)ethyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

CAS 438225-35-5C₂₃H₃₁NO₃S

N-[(2,3-Dimethoxyphenyl)methyl]-N-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C19H23NO3S, CAS 851183-72-7

N-[(2,3-Dimethoxyphenyl)methyl]-N-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

CAS 851183-72-7C₁₉H₂₃NO₃S

2-Amino-N-benzyl-6-ethyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C18H22N2OS, CAS 667435-68-9

2-Amino-N-benzyl-6-ethyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

CAS 667435-68-9C₁₈H₂₂N₂OS

2-Amino-N-benzyl-6-tert-pentyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide chemical structure, C21H28N2OS, CAS 667436-10-4

2-Amino-N-benzyl-6-tert-pentyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide

CAS 667436-10-4C₂₁H₂₈N₂OS

2-Amino-N-(4-methylbenzyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C17H20N2OS, CAS 725226-63-1

2-Amino-N-(4-methylbenzyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

CAS 725226-63-1C₁₇H₂₀N₂OS

2-Amino-6-methyl-N-(4-methylbenzyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C18H22N2OS, CAS 725226-64-2

2-Amino-6-methyl-N-(4-methylbenzyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

CAS 725226-64-2C₁₈H₂₂N₂OS

2-Amino-6-ethyl-N-(4-methylbenzyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C19H24N2OS, CAS 725226-66-4

2-Amino-6-ethyl-N-(4-methylbenzyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

CAS 725226-66-4C₁₉H₂₄N₂OS

2-Amino-6-tert-butyl-N-(4-methylbenzyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C21H28N2OS, CAS 725226-99-3

2-Amino-6-tert-butyl-N-(4-methylbenzyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

CAS 725226-99-3C₂₁H₂₈N₂OS

2-Amino-N-(4-methylbenzyl)-6-tert-pentyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide chemical structure, C22H30N2OS, CAS 725227-03-2

2-Amino-N-(4-methylbenzyl)-6-tert-pentyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide

CAS 725227-03-2C₂₂H₃₀N₂OS

N-[(3-Methoxyphenyl)methyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C17H19NO2S, CAS 1007744-49-1

N-[(3-Methoxyphenyl)methyl]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

CAS 1007744-49-1C₁₇H₁₉NO₂S

N-{[4-(Aminomethyl)-2-fluorophenyl]methyl}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide hydrochloride chemical structure, C17H20ClFN2OS, CAS 2418709-33-6

N-{[4-(Aminomethyl)-2-fluorophenyl]methyl}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide hydrochloride

CAS 2418709-33-6C₁₇H₂₀ClFN₂OS

N-{[4-(1-Aminoethyl)phenyl]methyl}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide chemical structure, C19H24N2OS, CAS 2445791-09-1

N-{[4-(1-Aminoethyl)phenyl]methyl}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

CAS 2445791-09-1C₁₉H₂₄N₂OS

N-{[4-(1-Aminoethyl)phenyl]methyl}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide hydrochloride chemical structure, C19H25ClN2OS, CAS 2445791-10-4

N-{[4-(1-Aminoethyl)phenyl]methyl}-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide hydrochloride

CAS 2445791-10-4C₁₉H₂₅ClN₂OS