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Murcko scaffold

Ring system with 3 rings and 25 atoms

11 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
25
Chemicals
11
With full pages
3
Scaffold SMILES

O=C(NCCN1CCN(C(=O)c2ccccc2)CC1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCCN1CCN(C(=O)c2ccccc2)CC1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 11 of 11 chemicals

4-Fluoro-N-[2-[4-(4-fluorobenzoyl)piperazin-1-yl]ethyl]benzamide chemical structure, C20H21F2N3O2, CAS 438452-51-8
4-Fluoro-N-[2-[4-(4-fluorobenzoyl)piperazin-1-yl]ethyl]benzamide
CAS 438452-51-8C20H21F2N3O2
N-[2-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]ethyl]-3,4-dimethoxybenzamide chemical structure, C24H31N3O6, CAS 381694-22-0
N-[2-[4-(3,4-Dimethoxybenzoyl)piperazin-1-yl]ethyl]-3,4-dimethoxybenzamide
CAS 381694-22-0C24H31N3O6
4-Bromo-N-[2-[4-(4-bromobenzoyl)piperazin-1-yl]ethyl]benzamide chemical structure, C20H21Br2N3O2, CAS 439094-88-9
4-Bromo-N-[2-[4-(4-bromobenzoyl)piperazin-1-yl]ethyl]benzamide
CAS 439094-88-9C20H21Br2N3O2
AK-968/11368992 chemical structure, C20H19Cl4N3O2, CAS 5545-57-3
AK-968/11368992
CAS 5545-57-3C20H19Cl4N3O2
4-Chloro-N-(2-{4-[(4-chlorophenyl)carbonyl]piperazin-1-yl}ethyl)benzamide chemical structure, C20H21Cl2N3O2, CAS 381713-53-7
4-Chloro-N-(2-{4-[(4-chlorophenyl)carbonyl]piperazin-1-yl}ethyl)benzamide
CAS 381713-53-7C20H21Cl2N3O2
4-Methoxy-N-{2-[4-(4-methoxybenzoyl)piperazin-1-yl]ethyl}benzamide chemical structure, C22H27N3O4, CAS 20088-03-3
4-Methoxy-N-{2-[4-(4-methoxybenzoyl)piperazin-1-yl]ethyl}benzamide
CAS 20088-03-3C22H27N3O4
3,4,5-Trimethoxy-N-{2-[4-(3,4,5-trimethoxybenzoyl)piperazino]ethyl}benzenecarboxamide chemical structure, C26H35N3O8, CAS 20088-04-4
3,4,5-Trimethoxy-N-{2-[4-(3,4,5-trimethoxybenzoyl)piperazino]ethyl}benzenecarboxamide
CAS 20088-04-4C26H35N3O8
3-Methoxy-N-[2-[4-(3-methoxybenzoyl)piperazin-1-yl]ethyl]benzamide chemical structure, C22H27N3O4, CAS 548450-81-3
3-Methoxy-N-[2-[4-(3-methoxybenzoyl)piperazin-1-yl]ethyl]benzamide
CAS 548450-81-3C22H27N3O4
2-Methyl-N-[2-[4-(2-methylbenzoyl)piperazin-1-yl]ethyl]benzamide chemical structure, C22H27N3O2, CAS 6374-84-1
2-Methyl-N-[2-[4-(2-methylbenzoyl)piperazin-1-yl]ethyl]benzamide
CAS 6374-84-1C22H27N3O2
3-(Trifluoromethyl)-N-(2-{4-[3-(trifluoromethyl)benzoyl]piperazin-1-yl}ethyl)benzamide hydrochloride chemical structure, C22H22ClF6N3O2, CAS 51673-26-8
3-(Trifluoromethyl)-N-(2-{4-[3-(trifluoromethyl)benzoyl]piperazin-1-yl}ethyl)benzamide hydrochloride
CAS 51673-26-8C22H22ClF6N3O2
4-tert-Butyl-N-{2-[4-(4-tert-butylbenzoyl)piperazin-1-yl]ethyl}benzamide hydrochloride chemical structure, C28H40ClN3O2, CAS 1033846-80-8
4-tert-Butyl-N-{2-[4-(4-tert-butylbenzoyl)piperazin-1-yl]ethyl}benzamide hydrochloride
CAS 1033846-80-8C28H40ClN3O2