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Impurities and reference standards

3-Hydroxyacetanilide

Also known as acetyl-m-aminophenol, 3-Acetamidophenol, Metacetamol

CAS 621-42-1Formula C8H9NO2Molar mass 151.17 g/molEC 210-687-0
GHS signal word: Warning. Pictograms: Harmful or irritant 21 suppliers listed
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3-Hydroxyacetanilide chemical structure, C8H9NO2, CAS 621-42-1
2D chemical structure

Key facts

What buyers check first

All properties
Physical form
Solid
Melting point
207.8 °C
Solubility
Less than 1 mg/mL at 72 °F
HS code
292429
Category
Impurities and reference standards
UN number
UN 2811
Illustrative photo, assorted laboratory chemical bottles and jars on a laboratory bench
Typical packagingIllustrative packaging image, not the actual product

What is 3-Hydroxyacetanilide?

Plain description, key identifiers and synonyms

Metacetamol is a derivative of phenol which has an acetamido substituent located meta to the phenolic -OH group. It is a non-toxic regioisomer of paracetamol with analgesic properties, but has never been marketed as a drug. It has a role as a non-narcotic analgesic. It is a member of acetamides and a member of phenols.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
N-(3-hydroxyphenyl)acetamide
CAS number
621-42-1 CAS number cross-checked
EC number
210-687-0
Molecular formula
C8H9NO2
UNII
V942ZCN81H
MDL number
MFCD00002263
InChIKey
QLNWXBAGRTUKKI-UHFFFAOYSA-N
InChI
InChI=1S/C8H9NO2/c1-6(10)9-7-3-2-4-8(11)5-7/h2-5,11H,1H3,(H,9,10)
SMILES (canonical and isomeric)
CC(=O)NC1=CC(=CC=C1)O

Synonyms

  • acetyl-m-aminophenol
  • 3-Acetamidophenol
  • Metacetamol
  • N-(3-Hydroxyphenyl)acetamide
  • 3'-Hydroxyacetanilide
  • m-Acetamidophenol
  • N-Acetyl-m-aminophenol
  • Pedituss
  • Acetamide, N-(3-hydroxyphenyl)-
  • Metalid
  • Pyrapap
  • Rystal
  • 3-(Acetylamino)phenol
  • m-Hydroxyacetanilide
  • m-(Acetylamino)phenol
  • m-Acetaminophenol
  • BS 749
  • Metacetamolum
  • Acetanilide, 3'-hydroxy-
  • 3-(Acetylamino)-1-hydroxybenzene
  • Metacetamol, 3'-Hydroxyacetanilide
  • BS 479
  • acetyl-2-aminophenol
  • Metacetamolo
  • Bosutinib Impurity 34
Show all 33 synonyms
  • 3-acetylaminophenol
  • N-(3-Hydroxyphenyl)acetamide (3-Acetamidophenol)
  • 3-Acetaminophenol
  • 3-acetamido phenol
  • 3-Hydroxyacetanilid
  • Paracetamol Impurity 19
  • N-m-hydroxyphenylacetamide
  • 3-Acetamidophenol, 97%

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Physical form
Solidexp.
Melting point
207.8 °Cexp.
Solubility
Less than 1 mg/mL at 72 °Fexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
151.17 g/molcalc.
Exact mass
151.0633 Dacalc.
LogP (octanol/water)
1.35calc.
Topological polar surface area
49.33 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
2calc.
Rotatable bonds
1calc.
Heavy atoms
11calc.
Rings
1calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.13calc.
Formal charge
0calc.
Stereocentres
0calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccccc1

c1ccccc1

1 ring, 6 atoms, the Benzene ring system.

485,677 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Warning
GHS07: Harmful or irritant
Harmful or irritant

Hazard statements

  • H315Causes skin irritation.
  • H319Causes serious eye irritation.
  • H335May cause respiratory irritation.
Precautionary statements (16)
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P264 + P265Wash skin thoroughly after handling. Do not touch eyes.
  • P271Use only outdoors or in a well-ventilated area.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P305 + P351 + P338If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P332 + P317If skin irritation occurs: Get medical help.
  • P337 + P317If eye irritation persists: Get medical help.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403 + P233Store in a well-ventilated place. Keep container tightly closed.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.
UN number
UN 2811

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

3-Hydroxyacetanilide suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 21 suppliers
21 of 21 offers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

21 suppliers in 9 countries

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3-Hydroxyacetanilide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Analgesics

Roles

  • analgesic
  • non-narcotic analgesic
  • pharmaceutical

Regulatory status

Inventories, regulations and trade controls that list this substance

United States

  • TSCA inventory (USA)
    Status: Active in US commerce

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code 3-Hydroxyacetanilide is traded under.

HS 2924.29Indicative HS code

Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other

World exports in 2024
$5.69B
−5.1% vs 2023, imports $5.8B
2019 to 2024
Top exporters
  1. China32.3%
  2. Switzerland * partner reported13.6%
  3. Norway * partner reported12.8%
Top importers
  1. United States15.9%
  2. Ireland15.8%
  3. Germany11.9%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for 3-Hydroxyacetanilide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about 3-Hydroxyacetanilide, based on the data on this page

What is 3-Hydroxyacetanilide?

Metacetamol is a derivative of phenol which has an acetamido substituent located meta to the phenolic -OH group. It is a non-toxic regioisomer of paracetamol with analgesic properties, but has never been marketed as a drug. It has a role as a non-narcotic analgesic. It is a member of acetamides and a member of phenols.

What is the CAS number of 3-Hydroxyacetanilide?

The CAS registry number of 3-Hydroxyacetanilide is 621-42-1.

What is the molecular formula and weight of 3-Hydroxyacetanilide?

The molecular formula of 3-Hydroxyacetanilide is C8H9NO2 and its molar mass is 151.17 g/mol.

What is 3-Hydroxyacetanilide used for?

Known uses and roles of 3-Hydroxyacetanilide include analgesic, non-narcotic analgesic, pharmaceutical and analgesics.

Is 3-Hydroxyacetanilide hazardous?

3-Hydroxyacetanilide carries the GHS signal word "Warning". Main hazards: causes skin irritation, causes serious eye irritation, may cause respiratory irritation. This summary is not an SDS, always read the supplier safety data sheet.

What is the HS code of 3-Hydroxyacetanilide?

3-Hydroxyacetanilide is usually classified under HS code 292429 (Cyclic amides (including cyclic carbamates) and their derivatives, salts thereof, other). This is indicative, confirm it with your customs broker before shipping.

Where can I buy 3-Hydroxyacetanilide?

CompoundList lists 21 suppliers of 3-Hydroxyacetanilide in China, United States, India, Canada and 5 more. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy 3-Hydroxyacetanilide in India?

3 suppliers in India list 3-Hydroxyacetanilide on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of 3-Hydroxyacetanilide?

Suppliers quote 3-Hydroxyacetanilide on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle 3-Hydroxyacetanilide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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