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Alkaloids

beta-Colubrine

Also known as 2-Methoxystrychnidin-10-one, Colubrine, beta, Strychnine, 2-methoxy-

CAS 509-36-4Formula C22H24N2O3Molar mass 364.45 g/mol
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beta-Colubrine chemical structure, C22H24N2O3, CAS 509-36-4
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
509-36-4
Formula
C22H24N2O3
Molar mass
364.45 g/mol
HS code
293979
Category
Alkaloids

What is beta-Colubrine?

Plain description, key identifiers and synonyms

Beta-colubrine is a monoterpenoid indole alkaloid that is strychnine in which the hydrogen at position 2 has been replaced by a methoxy group. It is a minor alkaloid from Strychnos nux-vomica. It has a role as a plant metabolite. It is an aromatic ether, an organic heteroheptacyclic compound and a monoterpenoid indole alkaloid. It is functionally related to a strychnine. It is a conjugate base of a beta-colubrine(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(4aR,5aS,8aR,13aS,15aS,15bR)-10-methoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one
CAS number
509-36-4 CAS number cross-checked
Molecular formula
C22H24N2O3
UNII
PEK2HDB6QQ
InChIKey
ZTHVHELPCLGXHF-JPPAUQSISA-N
InChI
InChI=1S/C22H24N2O3/c1-26-13-2-3-16-15(8-13)22-5-6-23-11-12-4-7-27-17-10-19(25)24(16)21(22)20(17)14(12)9-18(22)23/h2-4,8,14,17-18,20-21H,5-7,9-11H2,1H3/t14-,17-,18-,20-,21-,22+/m0/s1
Canonical SMILES
COc1ccc2c(c1)C13CCN4CC5=CCOC6CC(=O)N2C1C6C5CC43
Isomeric SMILES
COC1=CC2=C(C=C1)N3[C@@H]4[C@]25CCN6[C@H]5C[C@@H]7[C@H]4[C@H](CC3=O)OCC=C7C6

Synonyms

  • 2-Methoxystrychnidin-10-one
  • Colubrine, beta
  • Strychnine, 2-methoxy-
  • 2-Methoxy-strychnine
  • Strychnidin-10-one, 2-methoxy-
  • 10-Methoxystrychnine
  • (4aR,5aS,8aR,13aS,15aS,15bR)-10-methoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one
  • b-Colubrine
  • (4aR,5aS,8aR,13aS,15aS,15bR)-10-methoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo(3,2,1-ij)oxepino(2,3,4-de)pyrrolo(2,3-h)quinolin-14-one
  • Strychnidin-10-one, 2-methoxy-(9CI)
  • 2-Methoxystrychnine
  • 2-Methoxy strychnine
  • ss-Colubrin

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
364.45 g/molcalc.
Exact mass
364.1787 Dacalc.
LogP (octanol/water)
2.1calc.
Topological polar surface area
42.01 Ųcalc.
Hydrogen bond donors
0calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
1calc.
Heavy atoms
27calc.
Rings
7calc.
Aromatic rings
1calc.
Fraction sp3 carbons
0.59calc.
Formal charge
0calc.
Stereocentres
6calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1CC2OCC=C3CN4CCC56c7ccccc7N1C5C2C3CC46

O=C1CC2OCC=C3CN4CCC56c7ccccc7N1C5C2C3CC46

7 rings, 25 atoms.

93 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

beta-Colubrine suppliers

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beta-Colubrine price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Roles

  • eukaryotic metabolite
  • metabolite
  • plant metabolite

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code beta-Colubrine is traded under.

HS 2939.79Indicative HS code

Alkaloids of vegetal origin, other than cocaine, ecgonine, salts, esters and other derivatives, not elsewhere…

World exports in 2024
$701M
+18.9% vs 2023, imports $830M
2019 to 2024
Top exporters
  1. Switzerland * partner reported25.3%
  2. Germany21.4%
  3. India * partner reported14.9%
Top importers
  1. United States20.9%
  2. Germany14.7%
  3. Italy14.6%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for beta-Colubrine is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about beta-Colubrine, based on the data on this page

What is beta-Colubrine?

Beta-colubrine is a monoterpenoid indole alkaloid that is strychnine in which the hydrogen at position 2 has been replaced by a methoxy group. It is a minor alkaloid from Strychnos nux-vomica. It has a role as a plant metabolite.

What is the CAS number of beta-Colubrine?

The CAS registry number of beta-Colubrine is 509-36-4.

What is the molecular formula and weight of beta-Colubrine?

The molecular formula of beta-Colubrine is C22H24N2O3 and its molar mass is 364.45 g/mol.

What is beta-Colubrine used for?

Known uses and roles of beta-Colubrine include eukaryotic metabolite, metabolite and plant metabolite.

Is beta-Colubrine hazardous?

No GHS hazard classification for beta-Colubrine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of beta-Colubrine?

beta-Colubrine is usually classified under HS code 293979 (Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy beta-Colubrine?

Post a free request on CompoundList and suppliers of beta-Colubrine will send you quotes. Your contact details stay private until you accept a quote.

What is the price of beta-Colubrine?

Suppliers quote beta-Colubrine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle beta-Colubrine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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