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Hormones and steroids

Budesonide

Also known as Pulmicort, Rhinocort, Entocort

CAS 51333-22-3Formula C25H34O6Molar mass 430.54 g/molEC 257-139-7
GHS signal word: Danger. Pictograms: Harmful or irritant, Serious health hazard 168 suppliers listed Drug substance
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Budesonide chemical structure, C25H34O6, CAS 51333-22-3
2D chemical structure

Key facts

What buyers check first

All properties
Appearance
Crystals
Melting point
221 to 232
Solubility
Practically insoluble in water
HS code
293729
Category
Hormones and steroids
Illustrative photo, drums, an IBC tote and sacks in a chemical warehouse in a warehouse
Typical packagingIllustrative packaging image, not the actual product

What is Budesonide?

Plain description, key identifiers and synonyms

Budesonide is a glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis. It has a role as an anti-inflammatory drug, a bronchodilator agent and a drug allergen. It is a primary alpha-hydroxy ketone, a glucocorticoid, a 21-hydroxy steroid, an 11beta-hydroxy steroid, a 20-oxo steroid, a cyclic acetal and a 3-oxo-Delta(1),Delta(4)-steroid. It derives from a hydride of a pregnane.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one
CAS number
51333-22-3 CAS number cross-checked
EC number
257-139-7
Molecular formula
C25H34O6
UNII
Q3OKS62Q6X
MDL number
MFCD00083259
InChIKey
VOVIALXJUBGFJZ-KWVAZRHASA-N
InChI
InChI=1S/C25H34O6/c1-4-5-21-30-20-11-17-16-7-6-14-10-15(27)8-9-23(14,2)22(16)18(28)12-24(17,3)25(20,31-21)19(29)13-26/h8-10,16-18,20-22,26,28H,4-7,11-13H2,1-3H3/t16-,17-,18-,20+,21?,22+,23-,24-,25+/m0/s1
Canonical SMILES
CCCC1OC2CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC3(C)C2(C(=O)CO)O1
Isomeric SMILES
CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@@]5([C@H]4[C@H](C[C@@]3([C@@]2(O1)C(=O)CO)C)O)C

Synonyms

  • Pulmicort
  • Rhinocort
  • Entocort
  • Preferid
  • Rhinocort Aqua
  • Entocort EC
  • Uceris
  • Pulmicort Respules
  • Pulmicort Flexhaler
  • Budenofalk
  • Budesonido
  • Budesonidum
  • Pulmaxan
  • Rhinocort Allergy
  • Pulmicort turbuhaler
  • Eohilia
  • Budesonida
  • Eltair
  • Ortikos
  • (11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
  • 16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione
  • Uceris component budesonide
  • Breztri component budesonide
  • Airsupra component budesonide
  • (11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
Show all 39 synonyms
  • Pregna-1,4-diene-3,20-dione,16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11beta,16alpha)-
  • Tarpeyo
  • (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one
  • Aircort
  • Budecort
  • Butacort
  • Nasocort
  • Entocort cr
  • Duoresp spiromax
  • Budeflam aquanase
  • Budelin novolizer
  • Pulmicort l.s.
  • (1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo(10.8.0.0^(2,9).0^(4,8).0^(13,18))icosa-14,17-dien-16-one
  • Rhinocort aqua 64

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Appearance
Crystalsexp.
Melting point
221 to 232exp.
Solubility
Practically insoluble in waterexp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
430.54 g/molcalc.
Exact mass
430.2355 Dacalc.
LogP (octanol/water)
2.72calc.
Topological polar surface area
93.06 Ųcalc.
Hydrogen bond donors
2calc.
Hydrogen bond acceptors
6calc.
Rotatable bonds
4calc.
Heavy atoms
31calc.
Rings
5calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.76calc.
Formal charge
0calc.
Stereocentres
9calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC2C(=C1)CCC1C2CCC2C1CC1OCOC12

O=C1C=CC2C(=C1)CCC1C2CCC2C1CC1OCOC12

5 rings, 21 atoms.

180 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

GHS signal word
Danger
GHS07: Harmful or irritant
Harmful or irritant
GHS08: Serious health hazard
Serious health hazard

Hazard statements

  • H302Harmful if swallowed.
  • H312Harmful in contact with skin.
  • H315Causes skin irritation.
  • H317May cause an allergic skin reaction.
  • H332Harmful if inhaled.
  • H334May cause allergy or asthma symptoms or breathing difficulties if inhaled.
  • H361Suspected of damaging fertility or the unborn child.
  • H372Causes damage to organs through prolonged or repeated exposure.
  • H412Harmful to aquatic life with long lasting effects.
Precautionary statements (26)
  • P203Obtain, read and follow all safety instructions before use.
  • P233Keep container tightly closed.
  • P260Do not breathe dust, fume, gas, mist, vapours or spray.
  • P261Avoid breathing dust, fume, gas, mist, vapours or spray.
  • P264Wash skin thoroughly after handling.
  • P270Do not eat, drink or smoke when using this product.
  • P271Use only outdoors or in a well-ventilated area.
  • P272Contaminated work clothing should not be allowed out of the workplace.
  • P273Avoid release to the environment.
  • P280Wear protective gloves, protective clothing, eye protection and face protection.
  • P284In case of inadequate ventilation wear respiratory protection.
  • P301 + P317If swallowed: Get medical help.
  • P302 + P352If on skin: Wash with plenty of water.
  • P304 + P340If inhaled: Remove person to fresh air and keep comfortable for breathing.
  • P317Get medical help.
  • P318If exposed or concerned, get medical advice.
  • P319Get medical help if you feel unwell.
  • P321Specific treatment (see supplemental first aid instructions on the label).
  • P330Rinse mouth.
  • P332 + P317If skin irritation occurs: Get medical help.
  • P333 + P317If skin irritation or rash occurs: Get medical help.
  • P342 + P316If experiencing respiratory symptoms: Get emergency medical help immediately.
  • P362 + P364Take off contaminated clothing. And wash it before reuse.
  • P403Store in a well-ventilated place.
  • P405Store locked up.
  • P501Dispose of contents and container in accordance with local regulations.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Full safety data and first aid

Budesonide suppliers

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All 168 suppliers
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Where suppliers are based

168 suppliers in 29 countries

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Budesonide price

Indicative price range per kg from live supplier offers

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Uses and applications

What the substance is used for, by industry and function

Anti-Inflammatory Agents, Bronchodilator Agents, Glucocorticoids.

Use classes: Pharmaceuticals.

Pharmacological actions

  • Anti-Inflammatory Agents
  • Bronchodilator Agents
  • Glucocorticoids

Roles

  • aetiopathogenetic role
  • allergen
  • anti-allergic agent
  • anti-asthmatic agent
  • anti-inflammatory agent
  • anti-inflammatory drug
  • antimicrobial agent
  • antineoplastic agent
  • antiviral agent
  • bronchodilator agent
  • drug allergen
  • nasal decongestant
  • pharmaceutical

Pharmacology

Budesonide is a Corticosteroid. The mechanism of action of budesonide is as a Corticosteroid Hormone Receptor Agonist.

How it is made

11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione is converted to the 16,17-acetal with butyraldehyde.

Preparation: R. L. Brattsand et al., German patent 2323215, eidem, USA patent 3929768 (1973, 1975 both to Bofors).

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • Active ingredient in FDA approved drug labels

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Budesonide is traded under.

HS 2937.29Indicative HS code

Steroidal hormones, their derivatives and structural analogues, other

World exports in 2024
$2.32B
+5.7% vs 2023, imports $2.41B
2019 to 2024
Top exporters
  1. Belgium25.3%
  2. United States24.9%
  3. China13.0%
Top importers
  1. Italy18.0%
  2. Canada13.0%
  3. Belgium12.2%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Budesonide is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Budesonide, based on the data on this page

What is Budesonide?

Budesonide is a glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis. It has a role as an anti-inflammatory drug, a bronchodilator agent and a drug allergen.

What is Budesonide used for?

Anti-Inflammatory Agents, Bronchodilator Agents, Glucocorticoids. Use classes: Pharmaceuticals.

Is Budesonide hazardous?

Budesonide carries the GHS signal word "Danger". Main hazards: harmful if swallowed, harmful in contact with skin, causes skin irritation. This summary is not an SDS, always read the supplier safety data sheet.

Guides for buyers

Practical guides that help when you source, ship or handle Budesonide

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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