Diazepam
Also known as Valium, Ansiolisina, Diazemuls
Key facts
What buyers check first
- Appearance
- Colorless to light yellow crysytals
- Melting point
- 132 °C
- Solubility
- One gram of diazepam dissolves in about 350 mL of water, in approximately 15 mL of 95% e…
- HS code
- 293391
- Category
- Central nervous system drugs
What is Diazepam?
Plain description, key identifiers and synonyms
Diazepam is a 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5. It has a role as an anxiolytic drug, an anticonvulsant, a xenobiotic, a sedative and an environmental contaminant. It is a 1,4-benzodiazepinone and an organochlorine compound.
Diazepam is a benzodiazepine sedative.
Identifiers
Registry numbers, names and line notations, tap to copy
- IUPAC name
- 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
- CAS number
- 439-14-5 CAS number cross-checkedOther or deprecated CAS: 11100-37-1
- EC number
- 207-122-5
- Molecular formula
- C16H13ClN2O
- UNII
- Q3JTX2Q7TU
- InChIKey
- AAOVKJBEBIDNHE-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
- SMILES (canonical and isomeric)
- CN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
Synonyms
- Valium
- Ansiolisina
- Diazemuls
- Apaurin
- Faustan
- Relanium
- Seduxen
- Sibazon
- Stesolid
- Bialzepam
- Ceregulart
- Neurolytril
- Serenamin
- Valrelease
- Alboral
- Ansiolin
- Apozepam
- Atensine
- Calmpose
- Cercine
- Lembrol
- Morosan
- Setonil
- Sonacon
- Stesolin
Show all 39 synonymsShow fewer synonyms
- Tranimul
- Atilen
- Duxen
- Eridan
- Levium
- Paxate
- Paxel
- Vivol
- Noan
- Methyldiazepinone
- Calmocitene
- Condition
- Diacepan
- Diazepan
Physical and chemical properties
Measured values and descriptors computed from the structure
Physical and chemical properties
Measured values, check the supplier specification for your grade
| Appearance | Colorless to light yellow crysytalsexp.Measured value |
|---|---|
| Odour | Practically no odorexp.Measured value |
| Melting point | 132 °Cexp.Measured value |
| Solubility | One gram of diazepam dissolves in about 350 mL of water, in approximately 15 mL of 95% ethanol, or in approximately 2 mL of chloroform.exp.Measured value |
Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.
Computed descriptors
Calculated from the structure, useful for screening and formulation
| Molecular weight | 284.75 g/molcalc.Computed value |
|---|---|
| Exact mass | 284.0716 Dacalc.Computed value |
| LogP (octanol/water) | 3.15calc.Computed value |
| Topological polar surface area | 32.67 Ųcalc.Computed value |
| Hydrogen bond donors | 0calc.Computed value |
| Hydrogen bond acceptors | 2calc.Computed value |
| Rotatable bonds | 1calc.Computed value |
| Heavy atoms | 20calc.Computed value |
| Rings | 3calc.Computed value |
| Aromatic rings | 2calc.Computed value |
| Fraction sp3 carbons | 0.13calc.Computed value |
| Formal charge | 0calc.Computed value |
| Stereocentres | 0calc.Computed value |
| Lipinski rule of five | Passes (0 violations)calc.Computed value |
Calculated for screening. Confirm critical figures with the supplier.
Murcko scaffold
The ring system that remains when every side chain is removed
O=C1CN=C(c2ccccc2)c2ccccc2N1
3 rings, 18 atoms, the RO-05-2921 ring system.
540 other chemicals share this scaffoldSafety and hazards
GHS classification summary, not a safety data sheet
Hazard statements
- H301Toxic if swallowed.
- H311Toxic in contact with skin.
Precautionary statements (12)
- P262Do not get in eyes, on skin, or on clothing.
- P264Wash skin thoroughly after handling.
- P270Do not eat, drink or smoke when using this product.
- P280Wear protective gloves, protective clothing, eye protection and face protection.
- P301 + P316If swallowed: Get emergency medical help immediately.
- P302 + P352If on skin: Wash with plenty of water.
- P316Get emergency medical help immediately.
- P321Specific treatment (see supplemental first aid instructions on the label).
- P330Rinse mouth.
- P361 + P364Take off immediately all contaminated clothing. And wash it before reuse.
- P405Store locked up.
- P501Dispose of contents and container in accordance with local regulations.
GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.
Full safety data and first aidDiazepam suppliers
Trading restrictions apply to this substance
Diazepam is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.
Listing and enquiries are not allowed for this substance.
Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2933.91 (benzodiazepines and related substances)
Our policy on controlled substancesDiazepam price
Indicative price range per kg from live supplier offers
Prices are not shown for prohibited substances.
Uses and applications
What the substance is used for, by industry and function
Diazepam is a Schedule IV controlled substance.
Veterinary medication:.
Use classes: Nervous System, Pharmaceuticals, Animal Drugs.
Industries and functions
Pharmacological actions
- Adjuvants, Anesthesia
- Anesthetics, Intravenous
- Anti-Anxiety Agents
- Anticonvulsants
- Antiemetics
- GABA Modulators
- Hypnotics and Sedatives
- Muscle Relaxants, Central
Roles
- analgesic
- anticonvulsant
- antidepressant
- antipsychotic agent
- anxiolytic drug
- central nervous system depressant
- central nervous system drug
- environmental contaminant
- pharmaceutical
- psychotropic drug
- sedative
- tranquilizing drug
- vulnerary
- xenobiotic
Functional uses
- Pharmaceutical
Pharmacology
Diazepam is a Benzodiazepine.
How it is made
By the reaction of 2-methylamino-5-chlorobenzophenone with ethyl glycinate or with bromoacetyl bromide followed by reaction with ammonia
Benzoyl chloride is reacted with para-chloroaniline in the presence of a zinc chloride catalyst. The resulting 2-amino-5-chlorobenzophenone is converted to the oxime with hydroxylamine and then cyclized to the chloromethylquinazoline-3- oxide by treatment with chloroacetyl chloride. When this is treated with alkali, ring enlargement occurs, giving 7-chloro-1,3-dihydro-5-phenyl-2H-1,4- benzodiazepin-2-one-4-oxide.
Read more
Raney nickel reduction of the oxide followed by methylation with dimethyl sulfate gives diazepam.
Diazepam can be prepared by several routes, eg, treatment of amino oxime, first with chloroacetyl chloride, then with base, (followed) by reduction of the N-oxide with hydrogen.
Regulatory status
Inventories, regulations and trade controls that list this substance
Diazepam is prohibited on CompoundList. Listings, quotes and messages are disabled. This page is kept for information only.
Listing and enquiries are not allowed for this substance.
Reference: UN Convention on Psychotropic Substances 1971, HS 2022 subheading 2933.91 (benzodiazepines and related substances)
Our policy on controlled substancesControls
- US DEA controlled substance or listed chemical
- Controlled psychotropic substance
Health and food
- Active ingredient in FDA approved drug labels
United States
- TSCA inventory (USA)Status: Active in US commerce
HS code and trade data
Customs classification and reported world trade statistics
Global trade
World import and export statistics for the HS code Diazepam is traded under.
Alprazolam (INN), camazepam (INN), chlordiazepoxide (INN), clonazepam (INN)…
- Italy37.7%
- United States22.7%
- India * partner reported9.8%
- Germany13.8%
- Spain10.4%
- United States10.2%
* Partner reported figures, a lower bound.
The HS code shown for Diazepam is indicative (it was matched by name in the HS nomenclature). Confirm the classification with your customs broker before shipping.
Related chemicals
Parent and salt forms, stereoisomers, similar structures and isomers
Salt and hydrate forms
Records that share this compound as their parent
Stereoisomers and isotopic forms
Same connectivity, different stereochemistry or isotopes (same InChIKey skeleton)
Similar structures
Nearest neighbours by Morgan fingerprint Tanimoto similarity
Same formula isomers
Different compounds that share this molecular formula
![9b-(4-Chlorophenyl)-1,2,3,9b-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one chemical structure, C16H13ClN2O, CAS 6038-49-9](/s/WUFFYAFXNGRHNO-UHFFFAOYSA-N.svg)
![4-Chloro-2-[(quinolin-8-ylamino)methyl]phenol chemical structure, C16H13ClN2O, CAS 731831-60-0](/s/MLBCNCYGCAFPAD-UHFFFAOYSA-N.svg)
Frequently asked questions
Quick answers about Diazepam, based on the data on this page
What is Diazepam?
What is the CAS number of Diazepam?
What is the molecular formula and weight of Diazepam?
What is Diazepam used for?
Is Diazepam hazardous?
What is the HS code of Diazepam?
Can I buy Diazepam on CompoundList?
Guides for buyers
Practical guides that help when you source, ship or handle Diazepam
- Article, QualityPharma grades explained: IP vs BP vs USP vs EPWhat the Indian, British, US and European pharmacopoeias are, how their monographs differ, what multi grade claims mean and why a grade alone does not make a product fit for medicines.Read
- Guide, SafetyHow to read a safety data sheet in 10 minutesA section by section method to pull the essentials out of any 16 section SDS: identity, hazards, composition, storage, PPE, properties, transport and emergency measures.Read
- Guide, SafetyGHS pictograms, signal words and hazard statements explainedA practical guide to the nine GHS pictograms, the signal words Danger and Warning, H and P statements, and how to read a chemical label in seconds.Read
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