CompoundList
Sign in
Heterocyclic building blocks

(-)-Higenamine

Also known as (S)-Norcoclaurine, Higenamine, (-)-, Coclaurine, O-demethyl-

CAS 22672-77-1Formula C16H17NO3Molar mass 271.32 g/mol
Get quotes Safety data
(-)-Higenamine chemical structure, C16H17NO3, CAS 22672-77-1
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
22672-77-1
Formula
C16H17NO3
Molar mass
271.32 g/mol
HS code
293349
Category
Heterocyclic building blocks

What is (-)-Higenamine?

Plain description, key identifiers and synonyms

(S)-norcoclaurine is a norcoclaurine. It is a conjugate base of a (S)-norcoclaurinium(1+).

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(1S)-1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol
CAS number
22672-77-1 CAS number cross-checked
Molecular formula
C16H17NO3
UNII
P94O9O6QM5
InChIKey
WZRCQWQRFZITDX-AWEZNQCLSA-N
InChI
InChI=1S/C16H17NO3/c18-12-3-1-10(2-4-12)7-14-13-9-16(20)15(19)8-11(13)5-6-17-14/h1-4,8-9,14,17-20H,5-7H2/t14-/m0/s1
Canonical SMILES
Oc1ccc(CC2NCCc3cc(O)c(O)cc32)cc1
Isomeric SMILES
C1CN[C@H](C2=CC(=C(C=C21)O)O)CC3=CC=C(C=C3)O

Synonyms

  • (S)-Norcoclaurine
  • Higenamine, (-)-
  • Coclaurine, O-demethyl-
  • (1S)-1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol
  • 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, (1S)-
  • 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, (S)-
  • (1S)-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
  • 6,7-Dihydroxy-(1S)-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline
  • (1S)-1-((4-hydroxyphenyl)methyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
  • 6,7-Dihydroxy-(1S)-((4-hydroxyphenyl)methyl)-1,2,3,4-tetrahydroisoquinoline
  • 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, (1S)-
  • (S)-Higenamine
  • (S)-(-)-Higenamine
  • (S)-1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
  • (-)-1-(S)-Norcoclaurine

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
271.32 g/molcalc.
Exact mass
271.1208 Dacalc.
LogP (octanol/water)
2.23calc.
Topological polar surface area
72.72 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CC2NCCc3ccccc32)cc1

c1ccc(CC2NCCc3ccccc32)cc1

3 rings, 17 atoms, the 1-Benzyl-1,2,3,4-tetrahydroisoquinoline ring system.

293 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

(-)-Higenamine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

No supplier listings yet

Post one free request and suppliers who make or trade (-)-Higenamine can send you quotes. Your contact details stay private until you accept a quote.

Request quotesSell this chemical

(-)-Higenamine price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

Get latest price

Uses and applications

What the substance is used for, by industry and function

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code (-)-Higenamine is traded under.

HS 2933.49Indicative HS code

Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…

World exports in 2024
$939M
−14.6% vs 2023, imports $1.48B
2019 to 2024
Top exporters
  1. China30.1%
  2. India * partner reported16.7%
  3. Switzerland * partner reported14.1%
Top importers
  1. United Kingdom19.2%
  2. Germany16.0%
  3. Romania8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for (-)-Higenamine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about (-)-Higenamine, based on the data on this page

What is (-)-Higenamine?

(S)-norcoclaurine is a norcoclaurine. It is a conjugate base of a (S)-norcoclaurinium(1+).

What is the CAS number of (-)-Higenamine?

The CAS registry number of (-)-Higenamine is 22672-77-1.

What is the molecular formula and weight of (-)-Higenamine?

The molecular formula of (-)-Higenamine is C16H17NO3 and its molar mass is 271.32 g/mol.

What is (-)-Higenamine used for?

Known uses and roles of (-)-Higenamine include building blocks in research and laboratory and screening compounds in research and laboratory.

Is (-)-Higenamine hazardous?

No GHS hazard classification for (-)-Higenamine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of (-)-Higenamine?

(-)-Higenamine is usually classified under HS code 293349 (Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy (-)-Higenamine?

Post a free request on CompoundList and suppliers of (-)-Higenamine will send you quotes. Your contact details stay private until you accept a quote.

What is the price of (-)-Higenamine?

Suppliers quote (-)-Higenamine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle (-)-Higenamine

Get quotes for (-)-Higenamine

Post one free request with your grade, quantity and destination. Matching suppliers send quotes you can compare side by side.
Post a request Sell (-)-Higenamine
Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
Embed this structure on your websiteShow code

Paste this code into your page to show the 2D structure of (-)-Higenamine with a 3D view, its CAS number where known and a link back to this page. Free to use with the link kept.

<iframe src="https://www.compoundlist.com/embed/structure/higenamine-22672-77-1" title="(-)-Higenamine structure on CompoundList" width="360" height="420" style="border:1px solid #E7E2DA;border-radius:12px;max-width:100%" loading="lazy" referrerpolicy="strict-origin-when-cross-origin"></iframe>
Preview the embed

Explore more in Heterocyclic building blocks or HS code 293349

Price on request
Free quotes, contact stays private
Get quotes