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Heterocyclic building blocks

Higenamine

Also known as (+-)-Norcoclaurine, (+-)-Demethylcoclaurine, DL-Demethylcoclaurine

CAS 5843-65-2Formula C16H17NO3Molar mass 271.32 g/mol
3 suppliers listed
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Higenamine chemical structure, C16H17NO3, CAS 5843-65-2
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
5843-65-2
Formula
C16H17NO3
Molar mass
271.32 g/mol
HS code
293349
Category
Heterocyclic building blocks

What is Higenamine?

Plain description, key identifiers and synonyms

(RS)-norcoclaurine is a norcoclaurine. It is a conjugate base of a (RS)-norcoclaurinium.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol
CAS number
5843-65-2 CAS number cross-checkedOther or deprecated CAS: 106032-53-5
Molecular formula
C16H17NO3
UNII
TBV5O16GAP
MDL number
MFCD01736979
InChIKey
WZRCQWQRFZITDX-UHFFFAOYSA-N
InChI
InChI=1S/C16H17NO3/c18-12-3-1-10(2-4-12)7-14-13-9-16(20)15(19)8-11(13)5-6-17-14/h1-4,8-9,14,17-20H,5-7H2
SMILES (canonical and isomeric)
C1CNC(C2=CC(=C(C=C21)O)O)CC3=CC=C(C=C3)O

Synonyms

  • (+-)-Norcoclaurine
  • (+-)-Demethylcoclaurine
  • DL-Demethylcoclaurine
  • (+-)-O-Demethylcoclaurine
  • O-demethylcoclaurine
  • 1-(p-hydroxybenzyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
  • Demethyl-Coclaurine
  • Norcoclaurine
  • (RS)-norcoclaurine
  • 1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol
  • 1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-6,7-diol
  • (+/-)-Higenamine - synthetic
  • (R,S)-Norcoclaurine
  • 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-6,7-isoquinolinediol
  • Demethylcoclaurine
  • 6,7-Dihydroxy-1-[(4-hydroxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline
  • (R)-Higenamine
  • Coclaurine, O-demethyl-, (+-)-
  • Higenamine - natural
  • Higenamine [M+H]+
  • 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, (+-)-
  • Norcoclaurine, Demethyl-Coclaurine
  • (+/-)-Demethylcoclaurine
  • 1,2,3,4-tetrahydro-1-(4-hydroxybenzyl)isoquinoline-6,7-diol
  • 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol #
Show all 28 synonyms
  • Isoquinolin-6,7-diol, 1,2,3,4-tetrahydro-1-[4-hydroxybenzyl]-
  • (+-)-1,2,3,4-Tetrahydro-1-((4-hydroxyphenyl)methyl)-6,7-isoquinolinediol
  • 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

No measured properties are recorded for this substance yet. Ask suppliers for a technical data sheet.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
271.32 g/molcalc.
Exact mass
271.1208 Dacalc.
LogP (octanol/water)
2.23calc.
Topological polar surface area
72.72 Ųcalc.
Hydrogen bond donors
4calc.
Hydrogen bond acceptors
4calc.
Rotatable bonds
2calc.
Heavy atoms
20calc.
Rings
3calc.
Aromatic rings
2calc.
Fraction sp3 carbons
0.25calc.
Formal charge
0calc.
Stereocentres
1calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, c1ccc(CC2NCCc3ccccc32)cc1

c1ccc(CC2NCCc3ccccc32)cc1

3 rings, 17 atoms, the 1-Benzyl-1,2,3,4-tetrahydroisoquinoline ring system.

293 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Higenamine suppliers

Sponsored listings first, then the documented ranking: membership, verification, replies, completeness, freshness and ratings

All 3 suppliers
  • Alchem Pharmtech, Inc.
    United States ManufacturerUnclaimed profile
    HigenamineGrade, purity and minimum order on request
    Price on request
    View
  • ChemFaces
    China, WuhanUnclaimed profile
    HigenamineGrade, purity and minimum order on request
    Price on request
    View
  • SkySail Bioscience
    China, ShanghaiUnclaimed profile
    HigenamineGrade, purity and minimum order on request
    Price on request
    View

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

3 suppliers in 2 countries

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Higenamine price

Indicative price range per kg from live supplier offers

No published prices right now

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Uses and applications

What the substance is used for, by industry and function

Pharmacological actions

  • Adrenergic beta-Agonists
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cardiotonic Agents
  • Fibrinolytic Agents

Regulatory status

Inventories, regulations and trade controls that list this substance

No regulatory list memberships are recorded for this substance yet. Always check the rules of the importing and exporting country before trade.

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Higenamine is traded under.

HS 2933.49Indicative HS code

Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…

World exports in 2024
$939M
−14.6% vs 2023, imports $1.48B
2019 to 2024
Top exporters
  1. China30.1%
  2. India * partner reported16.7%
  3. Switzerland * partner reported14.1%
Top importers
  1. United Kingdom19.2%
  2. Germany16.0%
  3. Romania8.3%

* Partner reported figures, a lower bound.

Reported customs values in USD, not prices.Full trade data

The HS code shown for Higenamine is indicative (it was assigned by structure rules). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Higenamine, based on the data on this page

What is Higenamine?

(RS)-norcoclaurine is a norcoclaurine. It is a conjugate base of a (RS)-norcoclaurinium.

What is the CAS number of Higenamine?

The CAS registry number of Higenamine is 5843-65-2. Other or deprecated CAS numbers: 106032-53-5.

What is the molecular formula and weight of Higenamine?

The molecular formula of Higenamine is C16H17NO3 and its molar mass is 271.32 g/mol.

What is Higenamine used for?

Known uses and roles of Higenamine include building blocks in research and laboratory, screening compounds in research and laboratory, adrenergic beta-agonists, anti-inflammatory agents, non-steroidal, cardiotonic agents and 1 more.

Is Higenamine hazardous?

No GHS hazard classification for Higenamine is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Higenamine?

Higenamine is usually classified under HS code 293349 (Compounds containing in the structure a quinoline or isoquinoline ring-system (whether…). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Higenamine?

CompoundList lists 3 suppliers of Higenamine in China and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

What is the price of Higenamine?

Suppliers quote Higenamine on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Higenamine

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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