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Steroids and sterols

Paramethasone

Also known as Dillar, Flumethone, Paramezone

CAS 53-33-8Formula C22H29FO5Molar mass 392.47 g/molEC 200-169-2
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Paramethasone chemical structure, C22H29FO5, CAS 53-33-8
2D chemical structure

Key facts

What buyers check first

All properties
CAS number
53-33-8
Formula
C22H29FO5
Molar mass
392.47 g/mol
Solubility
Fluffy, practically white, crystalline powder. Sol in chloroform, ether, and methanol, o…
HS code
293722
Category
Steroids and sterols

What is Paramethasone?

Plain description, key identifiers and synonyms

Paramethasone is a fluorinated steroid.

Identifiers

Registry numbers, names and line notations, tap to copy

IUPAC name
(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
CAS number
53-33-8 CAS number cross-checked
EC number
200-169-2
Molecular formula
C22H29FO5
UNII
VFC6ZX3584
InChIKey
MKPDWECBUAZOHP-AFYJWTTESA-N
InChI
InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1
Canonical SMILES
CC1CC2C3CC(F)C4=CC(=O)C=CC4(C)C3C(O)CC2(C)C1(O)C(=O)CO
Isomeric SMILES
C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@H]3[C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)C)F

Synonyms

  • Dillar
  • Flumethone
  • Paramezone
  • Cassenne
  • Cortiden
  • Metilar
  • Parametasona
  • Parametasone
  • Paramethasonum
  • 16alpha-Methyl-6alpha-fluoroprednisolone
  • 6alpha-Fluoro-16alpha-methylprednisolone
  • Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6alpha,11beta,16alpha)-
  • Pregna-1,4-diene-3,20-dione, 6alpha-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-
  • (1S,2R,8S,10S,11S,13R,14R,15S,17S)-8-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo(8.7.0.0^(2,7).0^(11,15))heptadeca-3,6-dien-5-one
  • (1S,2R,8S,10S,11S,13R,14R,15S,17S)-8-fluoro-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one
  • Alondra
  • Paramethasone (INN)
  • Dillar (TN)
  • Paramethason
  • (6alpha,11beta,16alpha)-6-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • 6alpha-Fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
  • Cortiden, 6-Fluoro-16-methylprednisolone
  • Paramethasone Solution in Methanol, 100ug/mL
  • Paramethasone Solution in Acetonitrile, 100ug/mL
  • (6alpha,11beta,16.alpha.)-6-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

Physical and chemical properties

Measured values and descriptors computed from the structure

Physical and chemical properties

Measured values, check the supplier specification for your grade

Solubility
Fluffy, practically white, crystalline powder. Sol in chloroform, ether, and methanol, odorless /acetate/exp.

Values vary by grade. Ask suppliers for the COA or TDS of the batch you buy.

Computed descriptors

Calculated from the structure, useful for screening and formulation

Molecular weight
392.47 g/molcalc.
Exact mass
392.1999 Dacalc.
LogP (octanol/water)
1.75calc.
Topological polar surface area
94.83 Ųcalc.
Hydrogen bond donors
3calc.
Hydrogen bond acceptors
5calc.
Rotatable bonds
2calc.
Heavy atoms
28calc.
Rings
4calc.
Aromatic rings
0calc.
Fraction sp3 carbons
0.73calc.
Formal charge
0calc.
Stereocentres
9calc.
Lipinski rule of five
Passes (0 violations)calc.

Calculated for screening. Confirm critical figures with the supplier.

Murcko scaffold

The ring system that remains when every side chain is removed

Murcko scaffold of this chemical, O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

O=C1C=CC2C(=C1)CCC1C3CCCC3CCC21

4 rings, 18 atoms.

956 other chemicals share this scaffold

Safety and hazards

GHS classification summary, not a safety data sheet

No GHS hazard classification is recorded for this substance yet. That does not mean it is harmless.

GHS classification summary, not a safety data sheet (SDS). Classifications can differ by supplier, grade and concentration. Always check the supplier's SDS.

Paramethasone suppliers

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All 2 suppliers

Suppliers marked Unclaimed profile have not claimed their profile yet. They are not verified by CompoundList, their offers are price on request and details may have changed, so please confirm them with the supplier. Company representatives can claim a profile with a business email on the company's own website domain. Our team verifies each claim and sends the result by email.

Where suppliers are based

2 suppliers in 2 countries

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Paramethasone price

Indicative price range per kg from live supplier offers

No published prices right now

Suppliers quote this chemical on request. Send one free request and compare quotes side by side.

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Uses and applications

What the substance is used for, by industry and function

Therapeutic category: Glucocorticoid.

Veterinary medication:.

Pharmacological actions

  • Anti-Inflammatory Agents
  • Glucocorticoids

How it is made

3-Hydroxy-16alpha-methylpregn-5-en-20-one acetate...is first subjected to series of standard steroid reactions to form 6alpha-fluoro-17,21-dihydroxy-16alpha-methylpregn-4-ene-3,20-dione. ...Then hydroxylated @ 11beta position by incubation with bovine adrenal glands &...converted to 21-acetate ester. Dehydrogenation with selenium dioxide in presence of pyridine completes synthesis with creation of 1,2 double bond. (Acetate)

Insertion of a 16 alpha-methyl group into the fluprednisolone molecule yields systemically active paramethasone.

Regulatory status

Inventories, regulations and trade controls that list this substance

Health and food

  • EU Cosmetics Regulation Annex II, prohibited in cosmetics
    Name: Paramethasone (INN), Ref no: 186, Annex ref: II/186

HS code and trade data

Customs classification and reported world trade statistics

Global trade

World import and export statistics for the HS code Paramethasone is traded under.

HS 2937.22Indicative HS code

Halogenated derivatives of corticosteroidal hormones

World exports in 2024
$1.65B
−29.3% vs 2023, imports $1.67B
2019 to 2024
Top exporters
  1. United Kingdom69.1%
  2. Italy7.8%
  3. Singapore5.6%
Top importers
  1. United States64.5%
  2. Spain5.1%
  3. United Kingdom3.7%
Reported customs values in USD, not prices.Full trade data

The HS code shown for Paramethasone is indicative (it is known at chapter level only). Confirm the classification with your customs broker before shipping.

Frequently asked questions

Quick answers about Paramethasone, based on the data on this page

What is Paramethasone?

Paramethasone is a fluorinated steroid.

What is the CAS number of Paramethasone?

The CAS registry number of Paramethasone is 53-33-8.

What is the molecular formula and weight of Paramethasone?

The molecular formula of Paramethasone is C22H29FO5 and its molar mass is 392.47 g/mol.

What is Paramethasone used for?

Therapeutic category: Glucocorticoid. Veterinary medication:.

Is Paramethasone hazardous?

No GHS hazard classification for Paramethasone is recorded on CompoundList yet. That does not prove it is safe. Always read the supplier safety data sheet.

What is the HS code of Paramethasone?

Paramethasone is usually classified under HS code 293722 (Halogenated derivatives of corticosteroidal hormones). This is indicative, confirm it with your customs broker before shipping.

Where can I buy Paramethasone?

CompoundList lists 2 suppliers of Paramethasone in India and United States. Send one free request to get and compare quotes. Your contact details stay private until you accept a quote.

Where can I buy Paramethasone in India?

1 supplier in India list Paramethasone on CompoundList. Filter the suppliers list by country and send a request to compare prices, grades and delivery times.

What is the price of Paramethasone?

Suppliers quote Paramethasone on request because prices depend on grade, purity, quantity and destination. A free request on CompoundList gets you several quotes to compare.

Guides for buyers

Practical guides that help when you source, ship or handle Paramethasone

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Data last updated 7 Oct 2026. Details may have changed, please confirm them with the supplier. Report an error on this page
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