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Murcko scaffold

Ring system with 4 rings and 21 atoms

49 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 21
Chemicals: 49
With full pages: 4

Scaffold SMILES

C1=CC(c2ccccc2)c2c(n[nH]c2-c2ccccc2)O1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold C1=CC(c2ccccc2)c2c(n[nH]c2-c2ccccc2)O1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 49 chemicals

6-Amino-4-(4-chloro-3-nitrophenyl)-3-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C19H12ClN5O3, CAS 327100-39-0

6-Amino-4-(4-chloro-3-nitrophenyl)-3-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 327100-39-0C₁₉H₁₂ClN₅O₃

6-Amino-4-(2-chlorophenyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C19H13ClN4O, CAS 315246-28-7

6-Amino-4-(2-chlorophenyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 315246-28-7C₁₉H₁₃ClN₄O

6-Amino-4-(2,6-dichlorophenyl)-3-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C19H12Cl2N4O, CAS 315246-30-1

6-Amino-4-(2,6-dichlorophenyl)-3-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 315246-30-1C₁₉H₁₂Cl₂N₄O

6-Amino-3,4-diphenyl-1H,4H-pyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C19H14N4O, CAS 340807-19-4

6-Amino-3,4-diphenyl-1H,4H-pyrano[2,3-c]pyrazole-5-carbonitrile

CAS 340807-19-4C₁₉H₁₄N₄O

6-Amino-4-(3-chlorophenyl)-3-(4-ethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C21H17ClN4O2, CAS 694456-02-5

6-Amino-4-(3-chlorophenyl)-3-(4-ethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 694456-02-5C₂₁H₁₇ClN₄O₂

6-Amino-3-(4-ethoxyphenyl)-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C21H18N4O2, CAS 694467-80-6

6-Amino-3-(4-ethoxyphenyl)-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 694467-80-6C₂₁H₁₈N₄O₂

6-Amino-3-(4-ethoxyphenyl)-4-(3-nitrophenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C21H17N5O4, CAS 694468-52-5

6-Amino-3-(4-ethoxyphenyl)-4-(3-nitrophenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 694468-52-5C₂₁H₁₇N₅O₄

6-Amino-3-(4-ethoxyphenyl)-4-(2,4,5-trimethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C24H24N4O5, CAS 713096-84-5

6-Amino-3-(4-ethoxyphenyl)-4-(2,4,5-trimethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 713096-84-5C₂₄H₂₄N₄O₅

6-Amino-4-(2-bromo-4,5-dimethoxyphenyl)-3-(4-ethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C23H21BrN4O4, CAS 713098-66-9

6-Amino-4-(2-bromo-4,5-dimethoxyphenyl)-3-(4-ethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 713098-66-9C₂₃H₂₁BrN₄O₄

6-Amino-4-(2-methylphenyl)-3-(4-methylphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C21H18N4O, CAS 667404-53-7

6-Amino-4-(2-methylphenyl)-3-(4-methylphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 667404-53-7C₂₁H₁₈N₄O

6-Amino-4-(2-chlorophenyl)-3-(4-methylphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C20H15ClN4O, CAS 494775-86-9

6-Amino-4-(2-chlorophenyl)-3-(4-methylphenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 494775-86-9C₂₀H₁₅ClN₄O

Methyl 4-[6-amino-5-cyano-3-(4-methoxyphenyl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]benzoate chemical structure, C22H18N4O4, CAS 700849-16-7

Methyl 4-[6-amino-5-cyano-3-(4-methoxyphenyl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]benzoate

CAS 700849-16-7C₂₂H₁₈N₄O₄

6-Amino-4-(4-chlorophenyl)-3-(2-fluorophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C19H12ClFN4O, CAS 665001-31-0

6-Amino-4-(4-chlorophenyl)-3-(2-fluorophenyl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 665001-31-0C₁₉H₁₂ClFN₄O

6-Amino-4-(2,4-dimethylphenyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C21H18N4O, CAS 665001-25-2

6-Amino-4-(2,4-dimethylphenyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 665001-25-2C₂₁H₁₈N₄O

6-Amino-4-(2,4-dichlorophenyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C19H12Cl2N4O, CAS 315246-29-8

6-Amino-4-(2,4-dichlorophenyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 315246-29-8C₁₉H₁₂Cl₂N₄O

6-Amino-4-(4-fluorophenyl)-3-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C19H13FN4O, CAS 315246-27-6

6-Amino-4-(4-fluorophenyl)-3-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 315246-27-6C₁₉H₁₃FN₄O

6-Amino-4-(3-methoxyphenyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C20H16N4O2, CAS 300803-76-3

6-Amino-4-(3-methoxyphenyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 300803-76-3C₂₀H₁₆N₄O₂

6-Amino-4-(4-chlorophenyl)-3-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C19H13ClN4O, CAS 168429-49-0

6-Amino-4-(4-chlorophenyl)-3-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 168429-49-0C₁₉H₁₃ClN₄O

6-Amino-4-(3,4-dimethoxyphenyl)-3-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C21H18N4O3, CAS 315246-25-4

6-Amino-4-(3,4-dimethoxyphenyl)-3-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 315246-25-4C₂₁H₁₈N₄O₃

6-Amino-4-(3,4-diethoxyphenyl)-3-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C23H22N4O3, CAS 445265-88-3

6-Amino-4-(3,4-diethoxyphenyl)-3-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 445265-88-3C₂₃H₂₂N₄O₃

6-Amino-4-(3,4-difluorophenyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C19H12F2N4O, CAS 371224-93-0

6-Amino-4-(3,4-difluorophenyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 371224-93-0C₁₉H₁₂F₂N₄O

6-Amino-4-(2,6-difluorophenyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C19H12F2N4O, CAS 371205-58-2

6-Amino-4-(2,6-difluorophenyl)-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 371205-58-2C₁₉H₁₂F₂N₄O

6-Amino-4-{2-[(1-methylethyl)oxy]phenyl}-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C22H20N4O2, CAS 4823-78-3

6-Amino-4-{2-[(1-methylethyl)oxy]phenyl}-3-phenyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 4823-78-3C₂₂H₂₀N₄O₂

6-Amino-3-phenyl-4-(2,4,5-trimethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile chemical structure, C22H20N4O4, CAS 309288-87-7

6-Amino-3-phenyl-4-(2,4,5-trimethoxyphenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

CAS 309288-87-7C₂₂H₂₀N₄O₄