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Murcko scaffold

N'-(2,5-Dioxo-1-phenylpyrrolidin-3-yl)pyridine-3-carbohydrazide scaffold

12 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
23
Chemicals
12
With full pages
6
Scaffold SMILES

O=C(NNC1CC(=O)N(c2ccccc2)C1=O)c1cccnc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the N'-(2,5-Dioxo-1-phenylpyrrolidin-3-yl)pyridine-3-carbohydrazide page
Murcko scaffold O=C(NNC1CC(=O)N(c2ccccc2)C1=O)c1cccnc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 12 of 12 chemicals

N'-[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]pyridine-3-carbohydrazide chemical structure, C16H13BrN4O3, CAS 957265-96-2
N'-[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]pyridine-3-carbohydrazide
CAS 957265-96-2C16H13BrN4O3
N'-{2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl}pyridine-3-carbohydrazide chemical structure, C17H13F3N4O3, CAS 525580-32-9
N'-{2,5-Dioxo-1-[3-(trifluoromethyl)phenyl]pyrrolidin-3-yl}pyridine-3-carbohydrazide
CAS 525580-32-9C17H13F3N4O3
N'-[1-(4-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]-N'-(2-methylpropanoyl)pyridine-3-carbohydrazide chemical structure, C20H19FN4O4, CAS 956764-56-0
N'-[1-(4-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]-N'-(2-methylpropanoyl)pyridine-3-carbohydrazide
CAS 956764-56-0C20H19FN4O4
N'-[1-(2-Methylphenyl)-2,5-dioxopyrrolidin-3-yl]pyridine-3-carbohydrazide chemical structure, C17H16N4O3, CAS 956370-29-9
N'-[1-(2-Methylphenyl)-2,5-dioxopyrrolidin-3-yl]pyridine-3-carbohydrazide
CAS 956370-29-9C17H16N4O3
N'-[1-(4-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-N'-propanoylpyridine-3-carbohydrazide chemical structure, C20H20N4O5, CAS 956369-54-3
N'-[1-(4-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-N'-propanoylpyridine-3-carbohydrazide
CAS 956369-54-3C20H20N4O5
N'-[1-(4-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]pyridine-3-carbohydrazide chemical structure, C16H13FN4O3, CAS 956441-81-9
N'-[1-(4-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]pyridine-3-carbohydrazide
CAS 956441-81-9C16H13FN4O3
N'-[2,5-Dioxo-1-(4-propan-2-ylphenyl)pyrrolidin-3-yl]pyridine-3-carbohydrazide chemical structure, C19H20N4O3, CAS 956779-28-5
N'-[2,5-Dioxo-1-(4-propan-2-ylphenyl)pyrrolidin-3-yl]pyridine-3-carbohydrazide
CAS 956779-28-5C19H20N4O3
N'-[1-(3-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]pyridine-3-carbohydrazide chemical structure, C17H16N4O4, CAS 487001-75-2
N'-[1-(3-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]pyridine-3-carbohydrazide
CAS 487001-75-2C17H16N4O4
N'-[1-(4-Chloro-2-methylphenyl)-2,5-dioxopyrrolidin-3-yl]pyridine-3-carbohydrazide chemical structure, C17H15ClN4O3, CAS 956782-75-5
N'-[1-(4-Chloro-2-methylphenyl)-2,5-dioxopyrrolidin-3-yl]pyridine-3-carbohydrazide
CAS 956782-75-5C17H15ClN4O3
N'-(2,5-Dioxo-1-phenylpyrrolidin-3-yl)pyridine-3-carbohydrazide chemical structure, C16H14N4O3, CAS 956187-99-8
N'-(2,5-Dioxo-1-phenylpyrrolidin-3-yl)pyridine-3-carbohydrazide
CAS 956187-99-8C16H14N4O3
N'-[1-(4-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]pyridine-3-carbohydrazide chemical structure, C17H16N4O4, CAS 957030-54-5
N'-[1-(4-Methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]pyridine-3-carbohydrazide
CAS 957030-54-5C17H16N4O4
N'-[1-(4-Ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]pyridine-3-carbohydrazide chemical structure, C18H18N4O4, CAS 1053083-73-0
N'-[1-(4-Ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]pyridine-3-carbohydrazide
CAS 1053083-73-0C18H18N4O4