Murcko scaffold
1-Phenyl-3-[(2-phenylethyl)amino]-2,5-pyrrolidinedione scaffold
136 chemicals on CompoundList share this ring system.
- Rings
- 3
- Scaffold atoms
- 22
- Chemicals
- 136
- With full pages
- 30
Scaffold SMILES
O=C1CC(NCCc2ccccc2)C(=O)N1c1ccccc1
A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.
Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.
Chemicals with this scaffold
Open one to see its structure, properties and suppliers.
Showing 1 to 48 of 136 chemicals
![1-(4-Ethoxyphenyl)-3-{[2-(2-fluorophenyl)ethyl]amino}-2,5-pyrrolidinedione chemical structure, C20H21FN2O3, CAS 357614-26-7](/s/MNQODASRMQMUJM-UHFFFAOYSA-N.svg)
1-(4-Ethoxyphenyl)-3-{[2-(2-fluorophenyl)ethyl]amino}-2,5-pyrrolidinedione
CAS 357614-26-7C20H21FN2O3
![3-{[2-(2-Fluorophenyl)ethyl]amino}-1-(4-propoxyphenyl)pyrrolidine-2,5-dione chemical structure, C21H23FN2O3, CAS 357614-25-6](/s/SIYKKZNHJPWOTF-UHFFFAOYSA-N.svg)
3-{[2-(2-Fluorophenyl)ethyl]amino}-1-(4-propoxyphenyl)pyrrolidine-2,5-dione
CAS 357614-25-6C21H23FN2O3
![1-(4-Fluorophenyl)-3-[(2-phenylethyl)amino]pyrrolidine-2,5-dione chemical structure, C18H17FN2O2, CAS 329775-51-1](/s/YEJHNHRRDHFVFK-UHFFFAOYSA-N.svg)
1-(4-Fluorophenyl)-3-[(2-phenylethyl)amino]pyrrolidine-2,5-dione
CAS 329775-51-1C18H17FN2O2
1-(3-Chlorophenyl)-3-(phenethylamino)pyrrolidine-2,5-dione
CAS 468092-01-5C18H17ClN2O2
![1-(4-Bromophenyl)-3-[(2-phenylethyl)amino]pyrrolidine-2,5-dione chemical structure, C18H17BrN2O2, CAS 195452-30-3](/s/WRAJUVCFXVFUAZ-UHFFFAOYSA-N.svg)
1-(4-Bromophenyl)-3-[(2-phenylethyl)amino]pyrrolidine-2,5-dione
CAS 195452-30-3C18H17BrN2O2
3-(Phenethylamino)-1-(4-propoxyphenyl)pyrrolidine-2,5-dione
CAS 331632-79-2C21H24N2O3
1-(4-Ethoxyphenyl)-3-(phenethylamino)pyrrolidine-2,5-dione
CAS 331416-21-8C20H22N2O3
![N-[1-(4-Ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-N-(2-phenylethyl)acetamide chemical structure, C22H24N2O4, CAS 340982-94-7](/s/QFHHPDSLYUNOOV-UHFFFAOYSA-N.svg)
N-[1-(4-Ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-N-(2-phenylethyl)acetamide
CAS 340982-94-7C22H24N2O4
![N-[1-(3-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-N-(2-phenylethyl)acetamide chemical structure, C20H19ClN2O3, CAS 468713-49-7](/s/LXTYRGGUXKAVII-UHFFFAOYSA-N.svg)
N-[1-(3-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-N-(2-phenylethyl)acetamide
CAS 468713-49-7C20H19ClN2O3
![1-(4-Methoxyphenyl)-3-[(2-phenylethyl)amino]pyrrolidine-2,5-dione chemical structure, C19H20N2O3, CAS 345951-01-1](/s/DWKRKLKJLINCOT-UHFFFAOYSA-N.svg)
1-(4-Methoxyphenyl)-3-[(2-phenylethyl)amino]pyrrolidine-2,5-dione
CAS 345951-01-1C19H20N2O3
![1-(4-Methoxyphenyl)-3-[2-(4-methoxyphenyl)ethylamino]pyrrolidine-2,5-dione chemical structure, C20H22N2O4, CAS 5601-73-0](/s/UHKHGUNYCCEGNN-UHFFFAOYSA-N.svg)
1-(4-Methoxyphenyl)-3-[2-(4-methoxyphenyl)ethylamino]pyrrolidine-2,5-dione
CAS 5601-73-0C20H22N2O4
![3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}-1-(4-methoxyphenyl)pyrrolidine-2,5-dione chemical structure, C21H24N2O5, CAS 345951-09-9](/s/ZHVHDJFDVFKQNU-UHFFFAOYSA-N.svg)
3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}-1-(4-methoxyphenyl)pyrrolidine-2,5-dione
CAS 345951-09-9C21H24N2O5
![1-(4-Fluorophenyl)-3-{[2-(4-methoxyphenyl)ethyl]amino}pyrrolidine-2,5-dione chemical structure, C19H19FN2O3, CAS 355403-41-7](/s/UMCHBZZFLHHLSY-UHFFFAOYSA-N.svg)
1-(4-Fluorophenyl)-3-{[2-(4-methoxyphenyl)ethyl]amino}pyrrolidine-2,5-dione
CAS 355403-41-7C19H19FN2O3
![3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}-1-(4-propoxyphenyl)pyrrolidine-2,5-dione chemical structure, C23H28N2O5, CAS 340696-61-9](/s/YJYWWSJLISLHTE-UHFFFAOYSA-N.svg)
3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}-1-(4-propoxyphenyl)pyrrolidine-2,5-dione
CAS 340696-61-9C23H28N2O5
![3-[2-(4-Methoxyphenyl)ethylamino]-1-(4-propoxyphenyl)pyrrolidine-2,5-dione chemical structure, C22H26N2O4, CAS 339989-46-7](/s/VCNNFWMSDYLBFS-UHFFFAOYSA-N.svg)
3-[2-(4-Methoxyphenyl)ethylamino]-1-(4-propoxyphenyl)pyrrolidine-2,5-dione
CAS 339989-46-7C22H26N2O4
![3-[2-(4-Methoxyphenyl)ethylamino]-1-phenylpyrrolidine-2,5-dione chemical structure, C19H20N2O3, CAS 345951-07-7](/s/LRDLZCMUUQTTMU-UHFFFAOYSA-N.svg)
3-[2-(4-Methoxyphenyl)ethylamino]-1-phenylpyrrolidine-2,5-dione
CAS 345951-07-7C19H20N2O3
![1-(4-Chlorophenyl)-3-[2-(4-methoxyphenyl)ethylamino]pyrrolidine-2,5-dione chemical structure, C19H19ClN2O3, CAS 497914-18-8](/s/OFOOEXYYRKFGSE-UHFFFAOYSA-N.svg)
1-(4-Chlorophenyl)-3-[2-(4-methoxyphenyl)ethylamino]pyrrolidine-2,5-dione
CAS 497914-18-8C19H19ClN2O3
![1-(4-Bromophenyl)-3-{[2-(3,4-dimethoxyphenyl)ethyl]amino}pyrrolidine-2,5-dione chemical structure, C20H21BrN2O4, CAS 418798-91-1](/s/GXQFJILSFNVXPG-UHFFFAOYSA-N.svg)
1-(4-Bromophenyl)-3-{[2-(3,4-dimethoxyphenyl)ethyl]amino}pyrrolidine-2,5-dione
CAS 418798-91-1C20H21BrN2O4
![N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-(2,5-dioxo-1-phenylpyrrolidin-3-yl)acetamide chemical structure, C22H24N2O5, CAS 497862-85-8](/s/ZYARCCMLZJFGFI-UHFFFAOYSA-N.svg)
N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-(2,5-dioxo-1-phenylpyrrolidin-3-yl)acetamide
CAS 497862-85-8C22H24N2O5
![1-(4-Bromophenyl)-3-[2-(4-methoxyphenyl)ethylamino]pyrrolidine-2,5-dione chemical structure, C19H19BrN2O3, CAS 459150-96-0](/s/MURJOXCCBPOZLD-UHFFFAOYSA-N.svg)
1-(4-Bromophenyl)-3-[2-(4-methoxyphenyl)ethylamino]pyrrolidine-2,5-dione
CAS 459150-96-0C19H19BrN2O3
![1-(4-Chlorophenyl)-3-[2-(3,4-dimethoxyphenyl)ethylamino]pyrrolidine-2,5-dione chemical structure, C20H21ClN2O4, CAS 345951-10-2](/s/JZYXCOZMMBSEMN-UHFFFAOYSA-N.svg)
1-(4-Chlorophenyl)-3-[2-(3,4-dimethoxyphenyl)ethylamino]pyrrolidine-2,5-dione
CAS 345951-10-2C20H21ClN2O4
![N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-[2,5-dioxo-1-(4-propoxyphenyl)pyrrolidin-3-yl]acetamide chemical structure, C25H30N2O6, CAS 497914-16-6](/s/YAONLXADWMDJFL-UHFFFAOYSA-N.svg)
N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-[2,5-dioxo-1-(4-propoxyphenyl)pyrrolidin-3-yl]acetamide
CAS 497914-16-6C25H30N2O6
![N-[1-(4-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide chemical structure, C22H23ClN2O5, CAS 340696-89-1](/s/ODQVUDWKAMOMAW-UHFFFAOYSA-N.svg)
N-[1-(4-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide
CAS 340696-89-1C22H23ClN2O5
![3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}-1-[4-(hexyloxy)phenyl]pyrrolidine-2,5-dione chemical structure, C26H34N2O5, CAS 469891-22-3](/s/FWVLCBLCDAZHNF-UHFFFAOYSA-N.svg)
3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}-1-[4-(hexyloxy)phenyl]pyrrolidine-2,5-dione
CAS 469891-22-3C26H34N2O5
- 3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}-1-(4-fluorophenyl)pyrrolidine-2,5-dione355403-42-8C20H21FN2O4
- 1-(4-Hexoxyphenyl)-3-[2-(4-methoxyphenyl)ethylamino]pyrrolidine-2,5-dione470469-28-4C25H32N2O4
- N-[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide470470-22-5C22H23BrN2O5
- 1-(4-Ethoxyphenyl)-3-[2-(4-methoxyphenyl)ethylamino]pyrrolidine-2,5-dione5664-54-0C21H24N2O4
- N-[1-(4-Ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-N-[2-(4-methoxyphenyl)ethyl]acetamide339988-83-9C23H26N2O5
- 4-((2,5-Dioxo-1-phenylpyrrolidin-3-yl)(phenethyl)amino)-4-oxobutanoic acid379223-38-8C22H22N2O5
- N-(2,5-Dioxo-1-phenylpyrrolidin-3-yl)-N-[2-(4-methoxyphenyl)ethyl]propanamide340696-86-8C22H24N2O4
- 4-((2,5-Dioxo-1-(4-propoxyphenyl)pyrrolidin-3-yl)(phenethyl)amino)-4-oxobutanoic acid470695-12-6C25H28N2O6
- N-[1-(4-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl]-N-[2-(4-methoxyphenyl)ethyl]propanamide470695-13-7C22H23ClN2O4
- N-[1-(4-Ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]-N-[2-(4-methoxyphenyl)ethyl]propanamide470695-14-8C24H28N2O5
- Methyl 4-[3-[2-(4-methoxyphenyl)ethylamino]-2,5-dioxopyrrolidin-1-yl]benzoate355142-88-0C21H22N2O5
- 4-{[1-(4-Ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl](2-phenylethyl)amino}-4-oxobutanoic acid340703-75-5C24H26N2O6
- 4-{[1-(4-Chlorophenyl)-2,5-dioxopyrrolidin-3-yl][2-(4-methoxyphenyl)ethyl]amino}-4-oxobutanoic acid5752-97-6C23H23ClN2O6
- Methyl 4-{2,5-dioxo-3-[(2-phenylethyl)amino]pyrrolidin-1-yl}benzoate355142-86-8C20H20N2O4
- 4-{(2,5-Dioxo-1-phenylpyrrolidin-3-yl)[2-(4-methoxyphenyl)ethyl]amino}-4-oxobutanoic acid355142-97-1C23H24N2O6
- N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-[1-(4-methoxyphenyl)-2,5-dioxopyrrolidin-3-yl]propanamide470695-36-4C24H28N2O6
- 4-(2-{[1-(3-Ethoxyphenyl)-2,5-dioxopyrrolidin-3-yl]amino}ethyl)benzenesulfonamide351978-99-9C20H23N3O5S
- N-[1-(4-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]-N-(2-phenylethyl)propanamide317342-34-0C21H21FN2O3
- N-[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]-N-[2-(4-methoxyphenyl)ethyl]propanamide340703-47-1C22H23BrN2O4
- N-[2-(3,4-Dimethoxyphenyl)ethyl]-N-[2,5-dioxo-1-(4-propoxyphenyl)pyrrolidin-3-yl]propanamide470695-58-0C26H32N2O6
- N-[1-(4-Bromophenyl)-2,5-dioxopyrrolidin-3-yl]-N-[2-(4-methoxyphenyl)ethyl]acetamide355403-67-7C21H21BrN2O4
- 4-(2-{[1-(2-Fluorophenyl)-2,5-dioxopyrrolidin-3-yl]amino}ethyl)benzenesulfonamide340176-50-3C18H18FN3O4S
- N-(2,5-Dioxo-1-phenylpyrrolidin-3-yl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide355143-06-5C20H21N3O5S
- 1-(2-Fluorophenyl)-3-[2-(4-methoxyphenyl)ethylamino]pyrrolidine-2,5-dione355403-47-3C19H19FN2O3
Related scaffolds
Same ring framework with different atoms or bond orders
O=C(CSc1nnc(-c2ccccc2)o1)N1CCCCC127 chemicals
O=C(C=Cc1ccc(-c2ccccc2)o1)c1ccccc117 chemicals
O=C(Cc1ccccc1)Nc1nc(-c2ccccc2)cs115 chemicals
O=C(CSc1nnc(-c2ccccc2)o1)N1CCOCC113 chemicals
O=S(=O)(NCc1cc(-c2ccccc2)no1)c1ccccc113 chemicals
C(=NNc1nc(-c2ccccc2)cs1)c1ccccc112 chemicals
O=S(=O)(NCc1nc(-c2ccccc2)no1)c1ccccc111 chemicals![Scaffold O=C(Nc1ccccc1)Nc1c[nH]n(-c2ccccc2)c1=O](/scaffold/QSSZUVFMHJMXDP-UHFFFAOYSA-N/structure.svg)
O=C(Nc1ccccc1)Nc1c[nH]n(-c2ccccc2)c1=O11 chemicals
O=C(Cc1ccccc1)Nc1nnc(-c2ccccc2)o111 chemicals![Scaffold O=C(CSc1nnc(-c2ccccc2)[nH]1)c1ccccc1](/scaffold/DLNCASBDPGAELF-UHFFFAOYSA-N/structure.svg)
O=C(CSc1nnc(-c2ccccc2)[nH]1)c1ccccc110 chemicals
O=c1n(-c2ccccc2)cnn1CCOc1ccccc110 chemicals
O=C(CSc1nnc(-c2ccccc2)o1)c1ccccc110 chemicals