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Murcko scaffold

Ring system with 3 rings and 27 atoms

76 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
27
Chemicals
76
With full pages
65
Scaffold SMILES

O=C(COc1ccccc1)NN=Cc1ccc(OCc2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(COc1ccccc1)NN=Cc1ccc(OCc2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 76 chemicals

N'-({3-Bromo-4-[(2,4-dichlorophenyl)methoxy]-5-methoxyphenyl}methylidene)-2-(2-methoxyphenoxy)acetohydrazide chemical structure, C24H21BrCl2N2O5, CAS 5726-10-3
N'-({3-Bromo-4-[(2,4-dichlorophenyl)methoxy]-5-methoxyphenyl}methylidene)-2-(2-methoxyphenoxy)acetohydrazide
CAS 5726-10-3C24H21BrCl2N2O5
N-[(E)-(3-Methoxy-4-phenylmethoxyphenyl)methylideneamino]-2-(2-nitrophenoxy)acetamide chemical structure, C23H21N3O6, CAS 328573-18-8
N-[(E)-(3-Methoxy-4-phenylmethoxyphenyl)methylideneamino]-2-(2-nitrophenoxy)acetamide
CAS 328573-18-8C23H21N3O6
N'-(4-(Benzyloxy)benzylidene)-2-(4-chlorophenoxy)propanohydrazide chemical structure, C23H21ClN2O3, CAS 302908-76-5
N'-(4-(Benzyloxy)benzylidene)-2-(4-chlorophenoxy)propanohydrazide
CAS 302908-76-5C23H21ClN2O3
2-(4-Cyanophenoxy)-N-[(E)-(4-phenylmethoxyphenyl)methylideneamino]propanamide chemical structure, C24H21N3O3, CAS 444940-16-3
2-(4-Cyanophenoxy)-N-[(E)-(4-phenylmethoxyphenyl)methylideneamino]propanamide
CAS 444940-16-3C24H21N3O3
N'-(4-(Benzyloxy)benzylidene)-2-(4-bromophenoxy)propanohydrazide chemical structure, C23H21BrN2O3, CAS 303088-01-9
N'-(4-(Benzyloxy)benzylidene)-2-(4-bromophenoxy)propanohydrazide
CAS 303088-01-9C23H21BrN2O3
2-(4-Chlorophenoxy)-N'-{4-[(2,6-dichlorobenzyl)oxy]-3-methoxybenzylidene}acetohydrazide chemical structure, C23H19Cl3N2O4, CAS 402771-83-9
2-(4-Chlorophenoxy)-N'-{4-[(2,6-dichlorobenzyl)oxy]-3-methoxybenzylidene}acetohydrazide
CAS 402771-83-9C23H19Cl3N2O4
N'-{4-[(3-Chlorobenzyl)oxy]-3-methoxybenzylidene}-2-(4-chlorophenoxy)acetohydrazide chemical structure, C23H20Cl2N2O4, CAS 404014-35-3
N'-{4-[(3-Chlorobenzyl)oxy]-3-methoxybenzylidene}-2-(4-chlorophenoxy)acetohydrazide
CAS 404014-35-3C23H20Cl2N2O4
N'-(4-(Benzyloxy)benzylidene)-2-(5-isopropyl-2-methylphenoxy)acetohydrazide chemical structure, C26H28N2O3, CAS 303087-83-4
N'-(4-(Benzyloxy)benzylidene)-2-(5-isopropyl-2-methylphenoxy)acetohydrazide
CAS 303087-83-4C26H28N2O3
N'-(4-(Benzyloxy)-3-methoxybenzylidene)-2-(4-propylphenoxy)acetohydrazide chemical structure, C26H28N2O4, CAS 302910-26-5
N'-(4-(Benzyloxy)-3-methoxybenzylidene)-2-(4-propylphenoxy)acetohydrazide
CAS 302910-26-5C26H28N2O4
N'-(4-(Benzyloxy)benzylidene)-2-(2-methylphenoxy)acetohydrazide chemical structure, C23H22N2O3, CAS 303086-48-8
N'-(4-(Benzyloxy)benzylidene)-2-(2-methylphenoxy)acetohydrazide
CAS 303086-48-8C23H22N2O3
N'-(4-(Benzyloxy)benzylidene)-2-(4-bromophenoxy)acetohydrazide chemical structure, C22H19BrN2O3, CAS 303064-89-3
N'-(4-(Benzyloxy)benzylidene)-2-(4-bromophenoxy)acetohydrazide
CAS 303064-89-3C22H19BrN2O3
N'-(4-(Benzyloxy)benzylidene)-2-(2-methoxyphenoxy)acetohydrazide chemical structure, C23H22N2O4, CAS 302910-14-1
N'-(4-(Benzyloxy)benzylidene)-2-(2-methoxyphenoxy)acetohydrazide
CAS 302910-14-1C23H22N2O4
N'-(4-(Benzyloxy)benzylidene)-2-(2-chlorophenoxy)acetohydrazide chemical structure, C22H19ClN2O3, CAS 409349-75-3
N'-(4-(Benzyloxy)benzylidene)-2-(2-chlorophenoxy)acetohydrazide
CAS 409349-75-3C22H19ClN2O3
N'-(4-(Benzyloxy)benzylidene)-2-(4-nitrophenoxy)acetohydrazide chemical structure, C22H19N3O5, CAS 303087-78-7
N'-(4-(Benzyloxy)benzylidene)-2-(4-nitrophenoxy)acetohydrazide
CAS 303087-78-7C22H19N3O5
N'-(4-((4-Chlorobenzyl)oxy)benzylidene)-2-(4-chlorophenoxy)acetohydrazide chemical structure, C22H18Cl2N2O3, CAS 478663-17-1
N'-(4-((4-Chlorobenzyl)oxy)benzylidene)-2-(4-chlorophenoxy)acetohydrazide
CAS 478663-17-1C22H18Cl2N2O3
2-(2-Allylphenoxy)-N'-((E)-{4-[(4-methylbenzyl)oxy]phenyl}methylidene)acetohydrazide chemical structure, C26H26N2O3, CAS 767306-58-1
2-(2-Allylphenoxy)-N'-((E)-{4-[(4-methylbenzyl)oxy]phenyl}methylidene)acetohydrazide
CAS 767306-58-1C26H26N2O3
2-(5-Isopropyl-2-ME-phenoxy)-N'-(4-((4-ME-benzyl)oxy)benzylidene)acetohydrazide chemical structure, C27H30N2O3, CAS 769146-59-0
2-(5-Isopropyl-2-ME-phenoxy)-N'-(4-((4-ME-benzyl)oxy)benzylidene)acetohydrazide
CAS 769146-59-0C27H30N2O3
N'-(4-((4-CL-Benzyl)oxy)-3-ethoxybenzylidene)-2-(4-chlorophenoxy)acetohydrazide chemical structure, C24H22Cl2N2O4, CAS 396107-23-6
N'-(4-((4-CL-Benzyl)oxy)-3-ethoxybenzylidene)-2-(4-chlorophenoxy)acetohydrazide
CAS 396107-23-6C24H22Cl2N2O4
N'-(4-((4-Methylbenzyl)oxy)benzylidene)-2-phenoxyacetohydrazide chemical structure, C23H22N2O3, CAS 767305-76-0
N'-(4-((4-Methylbenzyl)oxy)benzylidene)-2-phenoxyacetohydrazide
CAS 767305-76-0C23H22N2O3
2-(2-Isopropyl-5-ME-phenoxy)-N'-(4-((4-ME-benzyl)oxy)benzylidene)acetohydrazide chemical structure, C27H30N2O3, CAS 767305-73-7
2-(2-Isopropyl-5-ME-phenoxy)-N'-(4-((4-ME-benzyl)oxy)benzylidene)acetohydrazide
CAS 767305-73-7C27H30N2O3
N'-((E)-{4-[(4-Chlorobenzyl)oxy]-3-ethoxyphenyl}methylidene)-2-(2-methylphenoxy)acetohydrazide chemical structure, C25H25ClN2O4, CAS 478527-88-7
N'-((E)-{4-[(4-Chlorobenzyl)oxy]-3-ethoxyphenyl}methylidene)-2-(2-methylphenoxy)acetohydrazide
CAS 478527-88-7C25H25ClN2O4
N'-(4-((4-CL-Benzyl)oxy)-3-ethoxybenzylidene)-2-(4-nitrophenoxy)propanohydrazide chemical structure, C25H24ClN3O6, CAS 767310-32-7
N'-(4-((4-CL-Benzyl)oxy)-3-ethoxybenzylidene)-2-(4-nitrophenoxy)propanohydrazide
CAS 767310-32-7C25H24ClN3O6
N'-(4-((4-Chlorobenzyl)oxy)-3-ethoxybenzylidene)-2-(4-F-phenoxy)acetohydrazide chemical structure, C24H22ClFN2O4, CAS 397287-96-6
N'-(4-((4-Chlorobenzyl)oxy)-3-ethoxybenzylidene)-2-(4-F-phenoxy)acetohydrazide
CAS 397287-96-6C24H22ClFN2O4
2-(3-Chlorophenoxy)-N'-(4-((4-methylbenzyl)oxy)benzylidene)propanohydrazide chemical structure, C24H23ClN2O3, CAS 767314-40-9
2-(3-Chlorophenoxy)-N'-(4-((4-methylbenzyl)oxy)benzylidene)propanohydrazide
CAS 767314-40-9C24H23ClN2O3