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Murcko scaffold

Ring system with 2 rings and 20 atoms

360 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
20
Chemicals
360
With full pages
9
Scaffold SMILES

O=C(NCCc1ccccc1)C(=O)Nc1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NCCc1ccccc1)C(=O)Nc1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 360 chemicals

N-[2-(3,4-Dimethoxyphenyl)ethyl]-N'-(4-methoxyphenyl)ethanediamide chemical structure, C19H22N2O5, CAS 330638-76-1
N-[2-(3,4-Dimethoxyphenyl)ethyl]-N'-(4-methoxyphenyl)ethanediamide
CAS 330638-76-1C19H22N2O5
N'-(3,4-Dimethylphenyl)-N-[2-(4-fluorophenyl)ethyl]oxamide chemical structure, C18H19FN2O2, CAS 496773-64-9
N'-(3,4-Dimethylphenyl)-N-[2-(4-fluorophenyl)ethyl]oxamide
CAS 496773-64-9C18H19FN2O2
N'-(2,3-Dichlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]oxamide chemical structure, C18H18Cl2N2O4, CAS 424806-50-8
N'-(2,3-Dichlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]oxamide
CAS 424806-50-8C18H18Cl2N2O4
N-(2,3-Dichlorophenyl)-N'-(2-phenylethyl)ethanediamide chemical structure, C16H14Cl2N2O2, CAS 330592-03-5
N-(2,3-Dichlorophenyl)-N'-(2-phenylethyl)ethanediamide
CAS 330592-03-5C16H14Cl2N2O2
N1-(4-fluorophenethyl)-N2-(2-methoxyphenyl)oxalamide chemical structure, C17H17FN2O3, CAS 498536-57-5
N1-(4-fluorophenethyl)-N2-(2-methoxyphenyl)oxalamide
CAS 498536-57-5C17H17FN2O3
N-(4-Chlorophenyl)-N'-(2-phenylethyl)ethanediamide chemical structure, C16H15ClN2O2, CAS 5378-89-2
N-(4-Chlorophenyl)-N'-(2-phenylethyl)ethanediamide
CAS 5378-89-2C16H15ClN2O2
N-(3,4-Dichlorophenyl)-N'-(2-phenylethyl)ethanediamide chemical structure, C16H14Cl2N2O2, CAS 331239-07-7
N-(3,4-Dichlorophenyl)-N'-(2-phenylethyl)ethanediamide
CAS 331239-07-7C16H14Cl2N2O2
N-(3-Chlorophenyl)-N'-(2-phenylethyl)ethanediamide chemical structure, C16H15ClN2O2, CAS 331239-08-8
N-(3-Chlorophenyl)-N'-(2-phenylethyl)ethanediamide
CAS 331239-08-8C16H15ClN2O2
N-[2-(3,4-Dimethoxyphenyl)ethyl]-N'-(4-propoxyphenyl)oxamide chemical structure, C21H26N2O5, CAS 404023-06-9
N-[2-(3,4-Dimethoxyphenyl)ethyl]-N'-(4-propoxyphenyl)oxamide
CAS 404023-06-9C21H26N2O5
N'-(4-tert-Butylphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]oxamide chemical structure, C22H28N2O4, CAS 381242-10-0
N'-(4-tert-Butylphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]oxamide
CAS 381242-10-0C22H28N2O4
N'-(4-Chloro-2-methylphenyl)-N-[2-(4-methoxyphenyl)ethyl]oxamide chemical structure, C18H19ClN2O3, CAS 423726-66-3
N'-(4-Chloro-2-methylphenyl)-N-[2-(4-methoxyphenyl)ethyl]oxamide
CAS 423726-66-3C18H19ClN2O3
N'-(4-Methoxyphenyl)-N-[2-(4-methoxyphenyl)ethyl]oxamide chemical structure, C18H20N2O4, CAS 423726-67-4
N'-(4-Methoxyphenyl)-N-[2-(4-methoxyphenyl)ethyl]oxamide
CAS 423726-67-4C18H20N2O4
N'-(3,4-Dichlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]oxamide chemical structure, C17H16Cl2N2O3, CAS 423726-72-1
N'-(3,4-Dichlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]oxamide
CAS 423726-72-1C17H16Cl2N2O3
N1-(2,5-dimethylphenyl)-N2-(4-methoxyphenethyl)oxalamide chemical structure, C19H22N2O3, CAS 331986-46-0
N1-(2,5-dimethylphenyl)-N2-(4-methoxyphenethyl)oxalamide
CAS 331986-46-0C19H22N2O3
N-[2-(4-Methoxyphenyl)ethyl]-N'-(4-methylphenyl)ethanediamide chemical structure, C18H20N2O3, CAS 423726-88-9
N-[2-(4-Methoxyphenyl)ethyl]-N'-(4-methylphenyl)ethanediamide
CAS 423726-88-9C18H20N2O3
N'-(2-Methoxy-5-methylphenyl)-N-(2-phenylethyl)oxamide chemical structure, C18H20N2O3, CAS 5916-17-6
N'-(2-Methoxy-5-methylphenyl)-N-(2-phenylethyl)oxamide
CAS 5916-17-6C18H20N2O3
N'-(2-Chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]oxamide chemical structure, C18H19ClN2O4, CAS 339083-23-7
N'-(2-Chlorophenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]oxamide
CAS 339083-23-7C18H19ClN2O4
N'-(3,4-Dimethylphenyl)-N-[2-(4-methoxyphenyl)ethyl]oxamide chemical structure, C19H22N2O3, CAS 423727-19-9
N'-(3,4-Dimethylphenyl)-N-[2-(4-methoxyphenyl)ethyl]oxamide
CAS 423727-19-9C19H22N2O3
N-(4-Fluorophenyl)-N'-[2-(4-methoxyphenyl)ethyl]ethanediamide chemical structure, C17H17FN2O3, CAS 423727-55-3
N-(4-Fluorophenyl)-N'-[2-(4-methoxyphenyl)ethyl]ethanediamide
CAS 423727-55-3C17H17FN2O3
N-[2-(3,4-Dimethoxyphenyl)ethyl]-N'-[4-(propan-2-yl)phenyl]ethanediamide chemical structure, C21H26N2O4, CAS 423727-90-6
N-[2-(3,4-Dimethoxyphenyl)ethyl]-N'-[4-(propan-2-yl)phenyl]ethanediamide
CAS 423727-90-6C21H26N2O4
N'-(5-Chloro-2-methylphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]oxamide chemical structure, C19H21ClN2O4, CAS 423727-94-0
N'-(5-Chloro-2-methylphenyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]oxamide
CAS 423727-94-0C19H21ClN2O4
N-(2-Methoxyphenyl)-N'-[2-(4-methoxyphenyl)ethyl]ethanediamide chemical structure, C18H20N2O4, CAS 423727-98-4
N-(2-Methoxyphenyl)-N'-[2-(4-methoxyphenyl)ethyl]ethanediamide
CAS 423727-98-4C18H20N2O4
N-(2-Fluorophenyl)-N'-(2-phenylethyl)ethanediamide chemical structure, C16H15FN2O2, CAS 300863-42-7
N-(2-Fluorophenyl)-N'-(2-phenylethyl)ethanediamide
CAS 300863-42-7C16H15FN2O2
N-(3-Chlorophenyl)-N'-[2-(4-methoxyphenyl)ethyl]ethanediamide chemical structure, C17H17ClN2O3, CAS 423728-14-7
N-(3-Chlorophenyl)-N'-[2-(4-methoxyphenyl)ethyl]ethanediamide
CAS 423728-14-7C17H17ClN2O3