CompoundList
Sign in
Murcko scaffold

Ring system with 3 rings and 21 atoms

36 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
36
With full pages
4
Scaffold SMILES

O=C(Nc1ccccc1)C1=CNC=CC1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)C1=CNC=CC1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 36 of 36 chemicals

5-Cyano-6-ethylsulfanyl-2-methyl-N,4-diphenyl-1,4-dihydropyridine-3-carboxamide chemical structure, C22H21N3OS, CAS 185409-69-2
5-Cyano-6-ethylsulfanyl-2-methyl-N,4-diphenyl-1,4-dihydropyridine-3-carboxamide
CAS 185409-69-2C22H21N3OS
Methyl 2-[[3-cyano-6-methyl-4-phenyl-5-(phenylcarbamoyl)-1,4-dihydropyridin-2-yl]sulfanyl]acetate chemical structure, C23H21N3O3S, CAS 185409-72-7
Methyl 2-[[3-cyano-6-methyl-4-phenyl-5-(phenylcarbamoyl)-1,4-dihydropyridin-2-yl]sulfanyl]acetate
CAS 185409-72-7C23H21N3O3S
5-Cyano-6-ethylsulfanyl-4-(4-hydroxyphenyl)-2-methyl-N-phenyl-1,4-dihydropyridine-3-carboxamide chemical structure, C22H21N3O2S, CAS 372087-32-6
5-Cyano-6-ethylsulfanyl-4-(4-hydroxyphenyl)-2-methyl-N-phenyl-1,4-dihydropyridine-3-carboxamide
CAS 372087-32-6C22H21N3O2S
4-(2-Chlorophenyl)-5-cyano-2-methyl-N-phenyl-6-propylsulfanyl-1,4-dihydropyridine-3-carboxamide chemical structure, C23H22ClN3OS, CAS 185409-93-2
4-(2-Chlorophenyl)-5-cyano-2-methyl-N-phenyl-6-propylsulfanyl-1,4-dihydropyridine-3-carboxamide
CAS 185409-93-2C23H22ClN3OS
4-(2-Chlorophenyl)-5-cyano-6-hexylsulfanyl-2-methyl-N-phenyl-1,4-dihydropyridine-3-carboxamide chemical structure, C26H28ClN3OS, CAS 185409-94-3
4-(2-Chlorophenyl)-5-cyano-6-hexylsulfanyl-2-methyl-N-phenyl-1,4-dihydropyridine-3-carboxamide
CAS 185409-94-3C26H28ClN3OS
4-(2-Chlorophenyl)-5-cyano-6-(cyanomethylsulfanyl)-2-methyl-N-phenyl-1,4-dihydropyridine-3-carboxamide chemical structure, C22H17ClN4OS, CAS 185409-80-7
4-(2-Chlorophenyl)-5-cyano-6-(cyanomethylsulfanyl)-2-methyl-N-phenyl-1,4-dihydropyridine-3-carboxamide
CAS 185409-80-7C22H17ClN4OS
6-((2-Amino-2-oxoethyl)thio)-4-(2-chlorophenyl)-5-cyano-2-methyl-N-phenyl-1,4-dihydropyridine-3-carboxamide chemical structure, C22H19ClN4O2S, CAS 185409-97-6
6-((2-Amino-2-oxoethyl)thio)-4-(2-chlorophenyl)-5-cyano-2-methyl-N-phenyl-1,4-dihydropyridine-3-carboxamide
CAS 185409-97-6C22H19ClN4O2S
4-(2-Chlorophenyl)-5-cyano-6-(ethylsulfanyl)-2-methyl-N-(2-methylphenyl)-1,4-dihydropyridine-3-carboxamide chemical structure, C23H22ClN3OS, CAS 328070-04-8
4-(2-Chlorophenyl)-5-cyano-6-(ethylsulfanyl)-2-methyl-N-(2-methylphenyl)-1,4-dihydropyridine-3-carboxamide
CAS 328070-04-8C23H22ClN3OS
4-(2-Chlorophenyl)-5-cyano-2-methyl-N-(2-methylphenyl)-6-(propylsulfanyl)-1,4-dihydropyridine-3-carboxamide chemical structure, C24H24ClN3OS, CAS 332045-85-9
4-(2-Chlorophenyl)-5-cyano-2-methyl-N-(2-methylphenyl)-6-(propylsulfanyl)-1,4-dihydropyridine-3-carboxamide
CAS 332045-85-9C24H24ClN3OS
AC1Mdqwf chemical structure, C22H20ClN3OS, CAS 5321-93-7
AC1Mdqwf
CAS 5321-93-7C22H20ClN3OS
4-(2-Chlorophenyl)-5-cyano-6-(ethylsulfanyl)-N-(2-methoxyphenyl)-2-methyl-1,4-dihydropyridine-3-carboxamide chemical structure, C23H22ClN3O2S, CAS 328070-44-6
4-(2-Chlorophenyl)-5-cyano-6-(ethylsulfanyl)-N-(2-methoxyphenyl)-2-methyl-1,4-dihydropyridine-3-carboxamide
CAS 328070-44-6C23H22ClN3O2S
5-Cyano-6-(ethylthio)-N-(2-methoxyphenyl)-2-methyl-4-phenyl-1,4-dihydropyridine-3-carboxamide chemical structure, C23H23N3O2S, CAS 375841-81-9
5-Cyano-6-(ethylthio)-N-(2-methoxyphenyl)-2-methyl-4-phenyl-1,4-dihydropyridine-3-carboxamide
CAS 375841-81-9C23H23N3O2S
4-(2-Chlorophenyl)-5-cyano-N-(2-methoxyphenyl)-2-methyl-6-(methylsulfanyl)-1,4-dihydropyridine-3-carboxamide chemical structure, C22H20ClN3O2S, CAS 332045-88-2
4-(2-Chlorophenyl)-5-cyano-N-(2-methoxyphenyl)-2-methyl-6-(methylsulfanyl)-1,4-dihydropyridine-3-carboxamide
CAS 332045-88-2C22H20ClN3O2S
6-((2-Amino-2-oxoethyl)thio)-5-cyano-N-(2-methoxyphenyl)-2-methyl-4-phenyl-1,4-dihydropyridine-3-carboxamide chemical structure, C23H22N4O3S, CAS 330179-87-8
6-((2-Amino-2-oxoethyl)thio)-5-cyano-N-(2-methoxyphenyl)-2-methyl-4-phenyl-1,4-dihydropyridine-3-carboxamide
CAS 330179-87-8C23H22N4O3S
6-((2-Amino-2-oxoethyl)thio)-4-(2-chlorophenyl)-5-cyano-2-methyl-N-(o-tolyl)-1,4-dihydropyridine-3-carboxamide chemical structure, C23H21ClN4O2S, CAS 374909-18-9
6-((2-Amino-2-oxoethyl)thio)-4-(2-chlorophenyl)-5-cyano-2-methyl-N-(o-tolyl)-1,4-dihydropyridine-3-carboxamide
CAS 374909-18-9C23H21ClN4O2S
5-Cyano-4-(2-fluorophenyl)-N-(2-methoxyphenyl)-2-methyl-6-(methylsulfanyl)-1,4-dihydropyridine-3-carboxamide chemical structure, C22H20FN3O2S, CAS 442557-87-1
5-Cyano-4-(2-fluorophenyl)-N-(2-methoxyphenyl)-2-methyl-6-(methylsulfanyl)-1,4-dihydropyridine-3-carboxamide
CAS 442557-87-1C22H20FN3O2S
Methyl ({3-cyano-4-(2-fluorophenyl)-5-[(2-methoxyphenyl)carbamoyl]-6-methyl-1,4-dihydropyridin-2-yl}sulfanyl)acetate chemical structure, C24H22FN3O4S, CAS 685095-39-0
Methyl ({3-cyano-4-(2-fluorophenyl)-5-[(2-methoxyphenyl)carbamoyl]-6-methyl-1,4-dihydropyridin-2-yl}sulfanyl)acetate
CAS 685095-39-0C24H22FN3O4S
3-Pyridinecarboxylic acid, 1,4-dihydro-4-(2-(difluoromethoxy)phenyl)-2,6-dimethyl-5-((phenylamino)carbonyl)-, ethyl ester chemical structure, C24H24F2N2O4, CAS 110544-73-5
3-Pyridinecarboxylic acid, 1,4-dihydro-4-(2-(difluoromethoxy)phenyl)-2,6-dimethyl-5-((phenylamino)carbonyl)-, ethyl ester
CAS 110544-73-5C24H24F2N2O4
6-(Allylthio)-4-(2-chlorophenyl)-5-cyano-N-(2-methoxyphenyl)-2-methyl-1,4-dihydropyridine-3-carboxamide chemical structure, C24H22ClN3O2S, CAS 332050-57-4
6-(Allylthio)-4-(2-chlorophenyl)-5-cyano-N-(2-methoxyphenyl)-2-methyl-1,4-dihydropyridine-3-carboxamide
CAS 332050-57-4C24H22ClN3O2S
4-(2-Chlorophenyl)-5-cyano-N-(2-methoxyphenyl)-2-methyl-6-propylsulfanyl-1,4-dihydropyridine-3-carboxamide chemical structure, C24H24ClN3O2S, CAS 330558-01-5
4-(2-Chlorophenyl)-5-cyano-N-(2-methoxyphenyl)-2-methyl-6-propylsulfanyl-1,4-dihydropyridine-3-carboxamide
CAS 330558-01-5C24H24ClN3O2S
6-((2-Amino-2-oxoethyl)thio)-4-(2-chlorophenyl)-5-cyano-N-(2-methoxyphenyl)-2-methyl-1,4-dihydropyridine-3-carboxamide chemical structure, C23H21ClN4O3S, CAS 330558-03-7
6-((2-Amino-2-oxoethyl)thio)-4-(2-chlorophenyl)-5-cyano-N-(2-methoxyphenyl)-2-methyl-1,4-dihydropyridine-3-carboxamide
CAS 330558-03-7C23H21ClN4O3S
6-((2-Amino-2-oxoethyl)thio)-4-(2-chlorophenyl)-N-(4-chlorophenyl)-5-cyano-2-methyl-1,4-dihydropyridine-3-carboxamide chemical structure, C22H18Cl2N4O2S, CAS 310454-30-9
6-((2-Amino-2-oxoethyl)thio)-4-(2-chlorophenyl)-N-(4-chlorophenyl)-5-cyano-2-methyl-1,4-dihydropyridine-3-carboxamide
CAS 310454-30-9C22H18Cl2N4O2S
4-(2-Chlorophenyl)-N-(4-chlorophenyl)-5-cyano-2-methyl-6-(methylsulfanyl)-1,4-dihydropyridine-3-carboxamide chemical structure, C21H17Cl2N3OS, CAS 332051-95-3
4-(2-Chlorophenyl)-N-(4-chlorophenyl)-5-cyano-2-methyl-6-(methylsulfanyl)-1,4-dihydropyridine-3-carboxamide
CAS 332051-95-3C21H17Cl2N3OS
Methyl ({3-cyano-5-[(2-methoxyphenyl)carbamoyl]-6-methyl-4-phenyl-1,4-dihydropyridin-2-yl}sulfanyl)acetate chemical structure, C24H23N3O4S, CAS 330557-87-4
Methyl ({3-cyano-5-[(2-methoxyphenyl)carbamoyl]-6-methyl-4-phenyl-1,4-dihydropyridin-2-yl}sulfanyl)acetate
CAS 330557-87-4C24H23N3O4S