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Murcko scaffold

Ring system with 3 rings and 17 atoms

31 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
17
Chemicals
31
With full pages
1
Scaffold SMILES

N=C1C(c2nccs2)=CCN1c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold N=C1C(c2nccs2)=CCN1c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 31 of 31 chemicals

5-Amino-1-(4-methoxyphenyl)-4-(4-methyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C15H15N3O2S, CAS 380387-78-0
5-Amino-1-(4-methoxyphenyl)-4-(4-methyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one
CAS 380387-78-0C15H15N3O2S
5-Amino-1-(2,4-dimethoxyphenyl)-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C17H19N3O3S, CAS 951960-08-0
5-Amino-1-(2,4-dimethoxyphenyl)-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one
CAS 951960-08-0C17H19N3O3S
5-Amino-1-(4-chlorophenyl)-4-(4-methyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C14H12ClN3OS, CAS 951969-91-8
5-Amino-1-(4-chlorophenyl)-4-(4-methyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one
CAS 951969-91-8C14H12ClN3OS
Methyl 4-[3-(4,5-dimethyl-1,3-thiazol-2-yl)-4-hydroxy-2-imino-2,5-dihydro-1H-pyrrol-1-yl]benzoate chemical structure, C17H17N3O3S, CAS 951960-00-2
Methyl 4-[3-(4,5-dimethyl-1,3-thiazol-2-yl)-4-hydroxy-2-imino-2,5-dihydro-1H-pyrrol-1-yl]benzoate
CAS 951960-00-2C17H17N3O3S
5-Amino-4-(4-methyl-1,3-thiazol-2-yl)-1-(3,4,5-trimethoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C17H19N3O4S, CAS 951956-59-5
5-Amino-4-(4-methyl-1,3-thiazol-2-yl)-1-(3,4,5-trimethoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one
CAS 951956-59-5C17H19N3O4S
4-[5-Amino-4-(4,5-dimethyl-1,3-thiazol-2-yl)-3-oxo-2,3-dihydro-1H-pyrrol-1-yl]benzenesulfonamide chemical structure, C15H16N4O3S2, CAS 951943-23-0
4-[5-Amino-4-(4,5-dimethyl-1,3-thiazol-2-yl)-3-oxo-2,3-dihydro-1H-pyrrol-1-yl]benzenesulfonamide
CAS 951943-23-0C15H16N4O3S2
4-(4,5-Dimethyl-1,3-thiazol-2-yl)-5-imino-1-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-3-ol chemical structure, C16H17N3O2S, CAS 1040689-40-4
4-(4,5-Dimethyl-1,3-thiazol-2-yl)-5-imino-1-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-3-ol
CAS 1040689-40-4C16H17N3O2S
5-Amino-1-(5-chloro-2,4-dimethoxyphenyl)-4-(4-methyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C16H16ClN3O3S, CAS 951974-59-7
5-Amino-1-(5-chloro-2,4-dimethoxyphenyl)-4-(4-methyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one
CAS 951974-59-7C16H16ClN3O3S
5-Amino-1-(3,4-dimethoxyphenyl)-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C17H19N3O3S, CAS 951972-86-4
5-Amino-1-(3,4-dimethoxyphenyl)-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one
CAS 951972-86-4C17H19N3O3S
N-{4-[4-Hydroxy-2-imino-3-(4-methyl-1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetamide chemical structure, C16H16N4O2S, CAS 951963-94-3
N-{4-[4-Hydroxy-2-imino-3-(4-methyl-1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetamide
CAS 951963-94-3C16H16N4O2S
1-(3,5-Dichlorophenyl)-5-imino-4-(4-methyl-1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrol-3-ol chemical structure, C14H11Cl2N3OS, CAS 951928-89-5
1-(3,5-Dichlorophenyl)-5-imino-4-(4-methyl-1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrol-3-ol
CAS 951928-89-5C14H11Cl2N3OS
Ethyl 3-[5-amino-4-(4,5-dimethyl-1,3-thiazol-2-yl)-3-oxo-2,3-dihydro-1H-pyrrol-1-yl]benzoate chemical structure, C18H19N3O3S, CAS 951991-59-6
Ethyl 3-[5-amino-4-(4,5-dimethyl-1,3-thiazol-2-yl)-3-oxo-2,3-dihydro-1H-pyrrol-1-yl]benzoate
CAS 951991-59-6C18H19N3O3S
5-Amino-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1-(4-isopropylphenyl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C18H21N3OS, CAS 951934-05-7
5-Amino-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1-(4-isopropylphenyl)-1,2-dihydro-3H-pyrrol-3-one
CAS 951934-05-7C18H21N3OS
5-Amino-1-(3-chloro-4-methoxyphenyl)-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C16H16ClN3O2S, CAS 951997-09-4
5-Amino-1-(3-chloro-4-methoxyphenyl)-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one
CAS 951997-09-4C16H16ClN3O2S
5-Amino-1-(3-chlorophenyl)-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C15H14ClN3OS, CAS 951959-00-5
5-Amino-1-(3-chlorophenyl)-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one
CAS 951959-00-5C15H14ClN3OS
N-{3-[4-Hydroxy-2-imino-3-(4-methyl-1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetamide chemical structure, C16H16N4O2S, CAS 951940-84-4
N-{3-[4-Hydroxy-2-imino-3-(4-methyl-1,3-thiazol-2-yl)-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetamide
CAS 951940-84-4C16H16N4O2S
5-Amino-1-[4-(dimethylamino)phenyl]-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C17H20N4OS, CAS 951987-30-7
5-Amino-1-[4-(dimethylamino)phenyl]-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one
CAS 951987-30-7C17H20N4OS
4-(4,5-Dimethyl-1,3-thiazol-2-yl)-5-imino-1-(3-methoxyphenyl)-2,5-dihydro-1H-pyrrol-3-ol chemical structure, C16H17N3O2S, CAS 951981-44-5
4-(4,5-Dimethyl-1,3-thiazol-2-yl)-5-imino-1-(3-methoxyphenyl)-2,5-dihydro-1H-pyrrol-3-ol
CAS 951981-44-5C16H17N3O2S
viFSP1 chemical structure, C16H17N3O3S, CAS 951945-67-8
viFSP1
CAS 951945-67-8C16H17N3O3S
5-Amino-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1-(3,4,5-trimethoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C18H21N3O4S, CAS 951973-40-3
5-Amino-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1-(3,4,5-trimethoxyphenyl)-1,2-dihydro-3H-pyrrol-3-one
CAS 951973-40-3C18H21N3O4S
5-Amino-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1-(2-isopropylphenyl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C18H21N3OS, CAS 951993-04-7
5-Amino-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1-(2-isopropylphenyl)-1,2-dihydro-3H-pyrrol-3-one
CAS 951993-04-7C18H21N3OS
N-{4-[3-(4,5-Dimethyl-1,3-thiazol-2-yl)-4-hydroxy-2-imino-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetamide chemical structure, C17H18N4O2S, CAS 951977-08-5
N-{4-[3-(4,5-Dimethyl-1,3-thiazol-2-yl)-4-hydroxy-2-imino-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetamide
CAS 951977-08-5C17H18N4O2S
5-Amino-1-(3,5-dimethoxyphenyl)-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C17H19N3O3S, CAS 951991-54-1
5-Amino-1-(3,5-dimethoxyphenyl)-4-(4,5-dimethyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one
CAS 951991-54-1C17H19N3O3S
5-Amino-1-(4-fluorophenyl)-4-(4-methyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one chemical structure, C14H12FN3OS, CAS 951951-64-7
5-Amino-1-(4-fluorophenyl)-4-(4-methyl-1,3-thiazol-2-yl)-1,2-dihydro-3H-pyrrol-3-one
CAS 951951-64-7C14H12FN3OS