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Murcko scaffold

Cyclobutenone scaffold

86 chemicals on CompoundList share this ring system.

Rings
1
Scaffold atoms
5
Chemicals
86
With full pages
3
Scaffold SMILES

O=C1C=CC1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks. This is a very common single ring, so the list below is broad.

Substructure search with this scaffoldOpen the Cyclobutenone page
Murcko scaffold O=C1C=CC1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 86 chemicals

2,3,4,4-Tetrachloro-2-cyclobuten-1-one chemical structure, C4Cl4O, CAS 3200-96-2
2,3,4,4-Tetrachloro-2-cyclobuten-1-one
CAS 3200-96-2C4Cl4O
Trichloro-2-cyclobuten-1-one chemical structure, C4HCl3O, CAS 78099-58-8
Trichloro-2-cyclobuten-1-one
CAS 78099-58-8C4HCl3O
Cyclobutenone chemical structure, C4H4O, CAS 32264-87-2
Cyclobutenone
CAS 32264-87-2C4H4O
2,4-Dibutyl-3-ethoxycyclobut-2-en-1-one chemical structure, C14H24O2, CAS 14273-25-7
2,4-Dibutyl-3-ethoxycyclobut-2-en-1-one
CAS 14273-25-7C14H24O2
3-Ethoxy-2,4-dimethylcyclobut-2-en-1-one chemical structure, C8H12O2, CAS 6613-56-5
3-Ethoxy-2,4-dimethylcyclobut-2-en-1-one
CAS 6613-56-5C8H12O2
2,3-Di-tert-butoxy-4-hydroxy-2-cyclobuten-1-one chemical structure, C12H20O4, CAS 144791-02-6
2,3-Di-tert-butoxy-4-hydroxy-2-cyclobuten-1-one
CAS 144791-02-6C12H20O4
3,4,4-Trimethoxy-2-methylcyclobut-2-en-1-one chemical structure, C8H12O4, CAS 156266-61-4
3,4,4-Trimethoxy-2-methylcyclobut-2-en-1-one
CAS 156266-61-4C8H12O4
3-Acetoxy-2-cyclobuten-1-one chemical structure, C6H6O3, CAS 38425-52-4
3-Acetoxy-2-cyclobuten-1-one
CAS 38425-52-4C6H6O3
2-Cyclobuten-1-one, 3-[3-(acetyloxy)propyl]-4,4-dichloro- chemical structure, C9H10Cl2O3, CAS 112381-32-5
2-Cyclobuten-1-one, 3-[3-(acetyloxy)propyl]-4,4-dichloro-
CAS 112381-32-5C9H10Cl2O3
2-Cyclobuten-1-one, 2,3-diethoxy-4-hydroxy-4-[(trimethylsilyl)ethynyl]- chemical structure, C13H20O4Si, CAS 109364-34-3
2-Cyclobuten-1-one, 2,3-diethoxy-4-hydroxy-4-[(trimethylsilyl)ethynyl]-
CAS 109364-34-3C13H20O4Si
4-Chloro-2,3-diethylcyclobut-2-EN-1-one chemical structure, C8H11ClO, CAS 148962-09-8
4-Chloro-2,3-diethylcyclobut-2-EN-1-one
CAS 148962-09-8C8H11ClO
3-Ethoxy-2-cyclobutenone chemical structure, C6H8O2, CAS 4683-54-9
3-Ethoxy-2-cyclobutenone
CAS 4683-54-9C6H8O2
Squaraine chemical structure, C4H4O2, CAS 78675-98-6
Squaraine
CAS 78675-98-6C4H4O2
2-Cyclobuten-1-one, 2,4,4-trimethyl- chemical structure, C7H10O, CAS 55701-64-9
2-Cyclobuten-1-one, 2,4,4-trimethyl-
CAS 55701-64-9C7H10O
3-Butylcyclobut-2-en-1-one chemical structure, C8H12O, CAS 38425-48-8
3-Butylcyclobut-2-en-1-one
CAS 38425-48-8C8H12O
2-Cyclobuten-1-one, 2-chloro-3-(dimethylamino)-4-hydroxy- chemical structure, C6H8ClNO2, CAS 71442-86-9
2-Cyclobuten-1-one, 2-chloro-3-(dimethylamino)-4-hydroxy-
CAS 71442-86-9C6H8ClNO2
3-Butyl-4,4-dichlorocyclobut-2-en-1-one chemical structure, C8H10Cl2O, CAS 72284-70-9
3-Butyl-4,4-dichlorocyclobut-2-en-1-one
CAS 72284-70-9C8H10Cl2O
2-Cyclobuten-1-one, 4,4-dichloro-2,3-dimethyl- chemical structure, C6H6Cl2O, CAS 72284-72-1
2-Cyclobuten-1-one, 4,4-dichloro-2,3-dimethyl-
CAS 72284-72-1C6H6Cl2O
2-Cyclobuten-1-one, 4,4-bis(trifluoromethyl)-3-[(trimethylsilyl)oxy]- chemical structure, C9H10F6O2Si, CAS 73774-99-9
2-Cyclobuten-1-one, 4,4-bis(trifluoromethyl)-3-[(trimethylsilyl)oxy]-
CAS 73774-99-9C9H10F6O2Si
4-Ethoxy-2,3-dimethylcyclobut-2-en-1-one chemical structure, C8H12O2, CAS 56787-63-4
4-Ethoxy-2,3-dimethylcyclobut-2-en-1-one
CAS 56787-63-4C8H12O2
2,3,4,4-Tetrafluorocyclobut-2-en-1-one chemical structure, C4F4O, CAS 60838-92-8
2,3,4,4-Tetrafluorocyclobut-2-en-1-one
CAS 60838-92-8C4F4O
3-tert-Butoxy-2,4-bis(propylsulfanyl)cyclobut-2-en-1-one chemical structure, C14H24O2S2, CAS 79894-57-8
3-tert-Butoxy-2,4-bis(propylsulfanyl)cyclobut-2-en-1-one
CAS 79894-57-8C14H24O2S2
3-Ethoxy-2-methylcyclobut-2-en-1-one chemical structure, C7H10O2, CAS 28750-50-7
3-Ethoxy-2-methylcyclobut-2-en-1-one
CAS 28750-50-7C7H10O2
3-Methylcyclobut-2-en-1-one chemical structure, C5H6O, CAS 83897-47-6
3-Methylcyclobut-2-en-1-one
CAS 83897-47-6C5H6O