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Murcko scaffold

Piperazine, 1-(1H-indol-3-yloxoacetyl)-4-phenyl- scaffold

34 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
34
With full pages
17
Scaffold SMILES

O=C(C(=O)N1CCN(c2ccccc2)CC1)c1c[nH]c2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Piperazine, 1-(1H-indol-3-yloxoacetyl)-4-phenyl- page
Murcko scaffold O=C(C(=O)N1CCN(c2ccccc2)CC1)c1c[nH]c2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 34 of 34 chemicals

Piperazine, 1-(1H-indol-3-yloxoacetyl)-4-phenyl- chemical structure, C20H19N3O2, CAS 71765-56-5
Piperazine, 1-(1H-indol-3-yloxoacetyl)-4-phenyl-
CAS 71765-56-5C20H19N3O2
1-[4-(2-Fluorophenyl)piperazin-1-yl]-2-(1H-indol-3-yl)ethane-1,2-dione chemical structure, C20H18FN3O2, CAS 852367-22-7
1-[4-(2-Fluorophenyl)piperazin-1-yl]-2-(1H-indol-3-yl)ethane-1,2-dione
CAS 852367-22-7C20H18FN3O2
1-(2-Methyl-1H-indol-3-yl)-2-(4-phenylpiperazin-1-yl)ethane-1,2-dione chemical structure, C21H21N3O2, CAS 696656-29-8
1-(2-Methyl-1H-indol-3-yl)-2-(4-phenylpiperazin-1-yl)ethane-1,2-dione
CAS 696656-29-8C21H21N3O2
1-(1-Methylindol-3-yl)-2-(4-phenylpiperazin-1-yl)ethane-1,2-dione chemical structure, C21H21N3O2, CAS 696606-03-8
1-(1-Methylindol-3-yl)-2-(4-phenylpiperazin-1-yl)ethane-1,2-dione
CAS 696606-03-8C21H21N3O2
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(1H-indol-3-yl)ethane-1,2-dione chemical structure, C20H18ClN3O2, CAS 852367-21-6
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(1H-indol-3-yl)ethane-1,2-dione
CAS 852367-21-6C20H18ClN3O2
1-[4-(4-Fluorophenyl)piperazin-1-yl]-2-(1H-indol-3-yl)ethane-1,2-dione chemical structure, C20H18FN3O2, CAS 852367-23-8
1-[4-(4-Fluorophenyl)piperazin-1-yl]-2-(1H-indol-3-yl)ethane-1,2-dione
CAS 852367-23-8C20H18FN3O2
1-(1H-Indol-3-yl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethane-1,2-dione chemical structure, C21H21N3O3, CAS 96265-45-1
1-(1H-Indol-3-yl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethane-1,2-dione
CAS 96265-45-1C21H21N3O3
1-(1H-Indol-3-yl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethane-1,2-dione chemical structure, C21H21N3O3, CAS 852367-24-9
1-(1H-Indol-3-yl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethane-1,2-dione
CAS 852367-24-9C21H21N3O3
1-[4-(4-Acetylphenyl)piperazin-1-yl]-2-(1H-indol-3-yl)ethane-1,2-dione chemical structure, C22H21N3O3, CAS 852368-14-0
1-[4-(4-Acetylphenyl)piperazin-1-yl]-2-(1H-indol-3-yl)ethane-1,2-dione
CAS 852368-14-0C22H21N3O3
1-[4-(2-Chlorophenyl)piperazin-1-yl]-2-(2-methyl-1H-indol-3-yl)ethane-1,2-dione chemical structure, C21H20ClN3O2, CAS 852368-55-9
1-[4-(2-Chlorophenyl)piperazin-1-yl]-2-(2-methyl-1H-indol-3-yl)ethane-1,2-dione
CAS 852368-55-9C21H20ClN3O2
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(2-methyl-1H-indol-3-yl)ethane-1,2-dione chemical structure, C21H20ClN3O2, CAS 852368-56-0
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(2-methyl-1H-indol-3-yl)ethane-1,2-dione
CAS 852368-56-0C21H20ClN3O2
1-[4-(2-Fluorophenyl)piperazin-1-yl]-2-(2-methyl-1H-indol-3-yl)ethane-1,2-dione chemical structure, C21H20FN3O2, CAS 852368-57-1
1-[4-(2-Fluorophenyl)piperazin-1-yl]-2-(2-methyl-1H-indol-3-yl)ethane-1,2-dione
CAS 852368-57-1C21H20FN3O2
1-[4-(4-Fluorophenyl)piperazin-1-yl]-2-(2-methyl-1H-indol-3-yl)ethane-1,2-dione chemical structure, C21H20FN3O2, CAS 852368-58-2
1-[4-(4-Fluorophenyl)piperazin-1-yl]-2-(2-methyl-1H-indol-3-yl)ethane-1,2-dione
CAS 852368-58-2C21H20FN3O2
1-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-(2-methyl-1H-indol-3-yl)ethane-1,2-dione chemical structure, C22H23N3O3, CAS 852368-59-3
1-[4-(4-Methoxyphenyl)piperazin-1-yl]-2-(2-methyl-1H-indol-3-yl)ethane-1,2-dione
CAS 852368-59-3C22H23N3O3
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-(2-methyl-1H-indol-3-yl)ethane-1,2-dione chemical structure, C22H23N3O3, CAS 852368-60-6
1-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-(2-methyl-1H-indol-3-yl)ethane-1,2-dione
CAS 852368-60-6C22H23N3O3
1-[4-(4-Acetylphenyl)piperazin-1-yl]-2-(2-methyl-1H-indol-3-yl)ethane-1,2-dione chemical structure, C23H23N3O3, CAS 862813-60-3
1-[4-(4-Acetylphenyl)piperazin-1-yl]-2-(2-methyl-1H-indol-3-yl)ethane-1,2-dione
CAS 862813-60-3C23H23N3O3
1-(1,2-Dimethyl-1H-indol-3-yl)-2-(4-phenylpiperazin-1-yl)ethane-1,2-dione chemical structure, C22H23N3O2, CAS 862814-12-8
1-(1,2-Dimethyl-1H-indol-3-yl)-2-(4-phenylpiperazin-1-yl)ethane-1,2-dione
CAS 862814-12-8C22H23N3O2
1-[4-(2-Chlorophenyl)piperazin-1-yl]-2-(1,2-dimethyl-1H-indol-3-yl)ethane-1,2-dione chemical structure, C22H22ClN3O2, CAS 862814-16-2
1-[4-(2-Chlorophenyl)piperazin-1-yl]-2-(1,2-dimethyl-1H-indol-3-yl)ethane-1,2-dione
CAS 862814-16-2C22H22ClN3O2
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(1,2-dimethyl-1H-indol-3-yl)ethane-1,2-dione chemical structure, C22H22ClN3O2, CAS 862814-17-3
1-[4-(3-Chlorophenyl)piperazin-1-yl]-2-(1,2-dimethyl-1H-indol-3-yl)ethane-1,2-dione
CAS 862814-17-3C22H22ClN3O2
1-(1,2-Dimethylindol-3-yl)-2-[4-(2-fluorophenyl)piperazin-1-yl]ethane-1,2-dione chemical structure, C22H22FN3O2, CAS 862814-18-4
1-(1,2-Dimethylindol-3-yl)-2-[4-(2-fluorophenyl)piperazin-1-yl]ethane-1,2-dione
CAS 862814-18-4C22H22FN3O2
1-(1,2-Dimethyl-1H-indol-3-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethane-1,2-dione chemical structure, C22H22FN3O2, CAS 862814-19-5
1-(1,2-Dimethyl-1H-indol-3-yl)-2-(4-(4-fluorophenyl)piperazin-1-yl)ethane-1,2-dione
CAS 862814-19-5C22H22FN3O2
1-(1,2-Dimethylindol-3-yl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethane-1,2-dione chemical structure, C23H25N3O3, CAS 862814-21-9
1-(1,2-Dimethylindol-3-yl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethane-1,2-dione
CAS 862814-21-9C23H25N3O3
1-[4-(4-Acetylphenyl)piperazin-1-yl]-2-(1,2-dimethylindol-3-yl)ethane-1,2-dione chemical structure, C24H25N3O3, CAS 862831-95-6
1-[4-(4-Acetylphenyl)piperazin-1-yl]-2-(1,2-dimethylindol-3-yl)ethane-1,2-dione
CAS 862831-95-6C24H25N3O3
1-(1H-Indol-3-yl)-2-[4-(4-nitrophenyl)piperazin-1-yl]ethane-1,2-dione chemical structure, C20H18N4O4, CAS 903329-54-4
1-(1H-Indol-3-yl)-2-[4-(4-nitrophenyl)piperazin-1-yl]ethane-1,2-dione
CAS 903329-54-4C20H18N4O4