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Murcko scaffold

1-(1H-Indol-3-yl)-2-(4-phenylpiperazin-1-yl)ethanone scaffold

13 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
24
Chemicals
13
With full pages
7
Scaffold SMILES

O=C(CN1CCN(c2ccccc2)CC1)c1c[nH]c2ccccc12

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1-(1H-Indol-3-yl)-2-(4-phenylpiperazin-1-yl)ethanone page
Murcko scaffold O=C(CN1CCN(c2ccccc2)CC1)c1c[nH]c2ccccc12

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

2-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-(2-methyl-1H-indol-3-yl)ethanone chemical structure, C22H25N3O2, CAS 871678-06-7
2-[4-(2-Methoxyphenyl)piperazin-1-yl]-1-(2-methyl-1H-indol-3-yl)ethanone
CAS 871678-06-7C22H25N3O2
1-(1H-Indol-3-yl)-2-(4-phenylpiperazin-1-yl)ethanone chemical structure, C20H21N3O, CAS 371930-76-6
1-(1H-Indol-3-yl)-2-(4-phenylpiperazin-1-yl)ethanone
CAS 371930-76-6C20H21N3O
1-(1H-Indol-3-yl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone chemical structure, C21H23N3O2, CAS 371945-03-8
1-(1H-Indol-3-yl)-2-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone
CAS 371945-03-8C21H23N3O2
1-(1H-Indol-3-yl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone chemical structure, C21H23N3O2, CAS 371202-25-4
1-(1H-Indol-3-yl)-2-[4-(4-methoxyphenyl)piperazin-1-yl]ethanone
CAS 371202-25-4C21H23N3O2
1-(1,2-Dimethylindol-3-yl)-2-(4-phenylpiperazin-1-yl)ethanone chemical structure, C22H25N3O, CAS 372087-13-3
1-(1,2-Dimethylindol-3-yl)-2-(4-phenylpiperazin-1-yl)ethanone
CAS 372087-13-3C22H25N3O
1-(2-Methyl-1H-indol-3-yl)-2-(4-phenylpiperazin-1-yl)ethanone chemical structure, C21H23N3O, CAS 371125-27-8
1-(2-Methyl-1H-indol-3-yl)-2-(4-phenylpiperazin-1-yl)ethanone
CAS 371125-27-8C21H23N3O
2-[4-(3-Methoxyphenyl)piperazin-1-yl]-1-(2-methyl-1H-indol-3-yl)ethanone chemical structure, C22H25N3O2, CAS 838844-46-5
2-[4-(3-Methoxyphenyl)piperazin-1-yl]-1-(2-methyl-1H-indol-3-yl)ethanone
CAS 838844-46-5C22H25N3O2
2-[4-(4-Methoxyphenyl)piperazin-1-yl]-1-(2-methyl-1H-indol-3-yl)ethanone chemical structure, C22H25N3O2, CAS 717892-41-6
2-[4-(4-Methoxyphenyl)piperazin-1-yl]-1-(2-methyl-1H-indol-3-yl)ethanone
CAS 717892-41-6C22H25N3O2
1-(5-Methoxy-1H-indol-3-yl)-2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethanone chemical structure, C22H22F3N3O2, CAS 374913-64-1
1-(5-Methoxy-1H-indol-3-yl)-2-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}ethanone
CAS 374913-64-1C22H22F3N3O2
2-[4-(4-Fluorophenyl)piperazin-1-yl]-1-(2-methyl-1H-indol-3-yl)ethanone chemical structure, C21H22FN3O, CAS 375358-62-6
2-[4-(4-Fluorophenyl)piperazin-1-yl]-1-(2-methyl-1H-indol-3-yl)ethanone
CAS 375358-62-6C21H22FN3O
2-[4-(2-Fluorophenyl)piperazin-1-yl]-1-(5-methoxy-1H-indol-3-yl)ethanone chemical structure, C21H22FN3O2, CAS 375837-75-5
2-[4-(2-Fluorophenyl)piperazin-1-yl]-1-(5-methoxy-1H-indol-3-yl)ethanone
CAS 375837-75-5C21H22FN3O2
2-[4-(2-Fluorophenyl)piperazin-1-yl]-1-(2-methyl-1H-indol-3-yl)ethanone chemical structure, C21H22FN3O, CAS 846583-79-7
2-[4-(2-Fluorophenyl)piperazin-1-yl]-1-(2-methyl-1H-indol-3-yl)ethanone
CAS 846583-79-7C21H22FN3O
2-[4-(4-Chlorophenyl)piperazin-1-yl]-1-(2-methyl-1H-indol-3-yl)ethanone chemical structure, C21H22ClN3O, CAS 892720-69-3
2-[4-(4-Chlorophenyl)piperazin-1-yl]-1-(2-methyl-1H-indol-3-yl)ethanone
CAS 892720-69-3C21H22ClN3O