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Murcko scaffold

Ring system with 4 rings and 25 atoms

9 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
25
Chemicals
9
With full pages
1
Scaffold SMILES

O=C(CC1C(=O)Nc2ccccc21)c1ccc(-c2ccccc2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CC1C(=O)Nc2ccccc21)c1ccc(-c2ccccc2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 9 of 9 chemicals

3-Hydroxy-3-[2-oxo-2-(4-phenylphenyl)ethyl]-1H-indol-2-one chemical structure, C22H17NO3, CAS 78660-87-4
3-Hydroxy-3-[2-oxo-2-(4-phenylphenyl)ethyl]-1H-indol-2-one
CAS 78660-87-4C22H17NO3
3-[2-(Biphenyl-4-yl)-2-oxoethyl]-1-ethyl-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C24H21NO3, CAS 421578-92-9
3-[2-(Biphenyl-4-yl)-2-oxoethyl]-1-ethyl-3-hydroxy-1,3-dihydro-2H-indol-2-one
CAS 421578-92-9C24H21NO3
3-(2-[1,1'-Biphenyl]-4-yl-2-oxoethyl)-3-hydroxy-1-(2-propynyl)-1,3-dihydro-2H-indol-2-one chemical structure, C25H19NO3, CAS 421579-18-2
3-(2-[1,1'-Biphenyl]-4-yl-2-oxoethyl)-3-hydroxy-1-(2-propynyl)-1,3-dihydro-2H-indol-2-one
CAS 421579-18-2C25H19NO3
3-Hydroxy-5-methyl-3-[2-oxo-2-(4-phenylphenyl)ethyl]-1H-indol-2-one chemical structure, C23H19NO3, CAS 371128-83-5
3-Hydroxy-5-methyl-3-[2-oxo-2-(4-phenylphenyl)ethyl]-1H-indol-2-one
CAS 371128-83-5C23H19NO3
3-Hydroxy-3-[2-oxo-2-(4-phenylphenyl)ethyl]-1-prop-2-enylindol-2-one chemical structure, C25H21NO3, CAS 434299-31-7
3-Hydroxy-3-[2-oxo-2-(4-phenylphenyl)ethyl]-1-prop-2-enylindol-2-one
CAS 434299-31-7C25H21NO3
3-[2-(Biphenyl-4-yl)-2-oxoethyl]-5-chloro-3-hydroxy-1,3-dihydro-2H-indol-2-one chemical structure, C22H16ClNO3, CAS 443636-36-0
3-[2-(Biphenyl-4-yl)-2-oxoethyl]-5-chloro-3-hydroxy-1,3-dihydro-2H-indol-2-one
CAS 443636-36-0C22H16ClNO3
5-Bromo-3-hydroxy-3-[2-oxo-2-(4-phenylphenyl)ethyl]-1-prop-2-enylindol-2-one chemical structure, C25H20BrNO3, CAS 689760-92-7
5-Bromo-3-hydroxy-3-[2-oxo-2-(4-phenylphenyl)ethyl]-1-prop-2-enylindol-2-one
CAS 689760-92-7C25H20BrNO3
3-Hydroxy-3-[2-oxo-2-(4-phenylphenyl)ethyl]-1-propylindol-2-one chemical structure, C25H23NO3, CAS 689754-97-0
3-Hydroxy-3-[2-oxo-2-(4-phenylphenyl)ethyl]-1-propylindol-2-one
CAS 689754-97-0C25H23NO3
3-[2-(Biphenyl-4-yl)-2-oxoethyl]-3-hydroxy-1-(propan-2-yl)-1,3-dihydro-2H-indol-2-one chemical structure, C25H23NO3, CAS 689756-50-1
3-[2-(Biphenyl-4-yl)-2-oxoethyl]-3-hydroxy-1-(propan-2-yl)-1,3-dihydro-2H-indol-2-one
CAS 689756-50-1C25H23NO3