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Murcko scaffold

Ring system with 2 rings and 13 atoms

97 chemicals on CompoundList share this ring system.

Rings
2
Scaffold atoms
13
Chemicals
97
With full pages
8
Scaffold SMILES

C(=Cc1cccs1)c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold C(=Cc1cccs1)c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 49 to 96 of 97 chemicals

(2E)-3-(3-Chlorophenyl)-2-thien-2-ylacrylic acid chemical structure, C13H9ClO2S
(2E)-3-(3-Chlorophenyl)-2-thien-2-ylacrylic acid
C13H9ClO2S
3-[4-(Propan-2-yl)phenyl]-2-(thiophen-2-yl)prop-2-enoic acid chemical structure, C16H16O2S, CAS 848369-60-8
3-[4-(Propan-2-yl)phenyl]-2-(thiophen-2-yl)prop-2-enoic acid
CAS 848369-60-8C16H16O2S
3-(4-Ethoxyphenyl)-2-(thiophen-2-yl)prop-2-enoic acid chemical structure, C15H14O3S, CAS 871673-16-4
3-(4-Ethoxyphenyl)-2-(thiophen-2-yl)prop-2-enoic acid
CAS 871673-16-4C15H14O3S
2-[2-(5-Bromo-thiophen-2-yl)-vinyl]-6-methoxy-benzoic acid ethyl ester chemical structure, C16H15BrO3S, CAS 365542-34-3
2-[2-(5-Bromo-thiophen-2-yl)-vinyl]-6-methoxy-benzoic acid ethyl ester
CAS 365542-34-3C16H15BrO3S
2-[(E)-3-Methoxy-3-oxo-1-thiophen-2-ylprop-1-en-2-yl]benzoic acid chemical structure, C15H12O4S, CAS 59417-09-3
2-[(E)-3-Methoxy-3-oxo-1-thiophen-2-ylprop-1-en-2-yl]benzoic acid
CAS 59417-09-3C15H12O4S
4-((1E)-2-(2-Thienyl)ethenyl)benzenamine chemical structure, C12H11NS, CAS 41839-01-4
4-((1E)-2-(2-Thienyl)ethenyl)benzenamine
CAS 41839-01-4C12H11NS
[2-Methyl-4-[(E)-2-thiophen-2-ylethenyl]phenyl] propanoate chemical structure, C16H16O2S, CAS 142115-47-7
[2-Methyl-4-[(E)-2-thiophen-2-ylethenyl]phenyl] propanoate
CAS 142115-47-7C16H16O2S
(E)-3-(3-Chloro-4-methoxyphenyl)-2-(2-thienyl)-2-propenenitrile chemical structure, C14H10ClNOS, CAS 900019-72-9
(E)-3-(3-Chloro-4-methoxyphenyl)-2-(2-thienyl)-2-propenenitrile
CAS 900019-72-9C14H10ClNOS
Ethanone, 1-[4-[2-(5-chloro-2-thienyl)ethenyl]phenyl]-, (E)- chemical structure, C14H11ClOS, CAS 69193-40-4
Ethanone, 1-[4-[2-(5-chloro-2-thienyl)ethenyl]phenyl]-, (E)-
CAS 69193-40-4C14H11ClOS
3-Bromo-6-[2-(5-chloro-thiophen-2-yl)-vinyl]-2-hydroxy-benzoic acid ethyl ester chemical structure, C15H12BrClO3S, CAS 365542-87-6
3-Bromo-6-[2-(5-chloro-thiophen-2-yl)-vinyl]-2-hydroxy-benzoic acid ethyl ester
CAS 365542-87-6C15H12BrClO3S
2-[2-(5-Bromo-thiophen-2-yl)-vinyl]-6-hydroxy-benzoic acid ethyl ester chemical structure, C15H13BrO3S, CAS 1171924-18-7
2-[2-(5-Bromo-thiophen-2-yl)-vinyl]-6-hydroxy-benzoic acid ethyl ester
CAS 1171924-18-7C15H13BrO3S
2-[2-(5-Bromo-thiophen-2-yl)-vinyl]-6-methoxy-benzoic acid methyl ester chemical structure, C15H13BrO3S, CAS 365543-18-6
2-[2-(5-Bromo-thiophen-2-yl)-vinyl]-6-methoxy-benzoic acid methyl ester
CAS 365543-18-6C15H13BrO3S
2,4-Diacetoxy-6-[2-(5-bromo-thiophen-2-yl)-vinyl]-benzoic acid ethyl ester chemical structure, C19H17BrO6S, CAS 365542-97-8
2,4-Diacetoxy-6-[2-(5-bromo-thiophen-2-yl)-vinyl]-benzoic acid ethyl ester
CAS 365542-97-8C19H17BrO6S
2-[2-(5-Bromo-thiophen-2-yl)-vinyl]-4,6-dihydroxy-benzoic acid ethyl ester chemical structure, C15H13BrO4S, CAS 819868-44-5
2-[2-(5-Bromo-thiophen-2-yl)-vinyl]-4,6-dihydroxy-benzoic acid ethyl ester
CAS 819868-44-5C15H13BrO4S
2-[2-(5-Bromo-thiophen-2-yl)-vinyl]-6-methoxy-benzoic acid chemical structure, C14H11BrO3S, CAS 365542-85-4
2-[2-(5-Bromo-thiophen-2-yl)-vinyl]-6-methoxy-benzoic acid
CAS 365542-85-4C14H11BrO3S
2-[2-(5-Chloro-thiophen-2-yl)-vinyl]-4,6-dihydroxy-benzoic acid ethyl ester chemical structure, C15H13ClO4S, CAS 365542-89-8
2-[2-(5-Chloro-thiophen-2-yl)-vinyl]-4,6-dihydroxy-benzoic acid ethyl ester
CAS 365542-89-8C15H13ClO4S
{2-[2-(5-Chloro-thiophen-2-yl)-vinyl]-6-methoxy-phenyl}-methanol chemical structure, C14H13ClO2S, CAS 1171924-32-5
{2-[2-(5-Chloro-thiophen-2-yl)-vinyl]-6-methoxy-phenyl}-methanol
CAS 1171924-32-5C14H13ClO2S
3,5-Dibromo-2-[2-(5-chloro-thiophen-2-yl)-vinyl]-4,6-dihydroxy-benzoic acid ethyl ester chemical structure, C15H11Br2ClO4S, CAS 365542-90-1
3,5-Dibromo-2-[2-(5-chloro-thiophen-2-yl)-vinyl]-4,6-dihydroxy-benzoic acid ethyl ester
CAS 365542-90-1C15H11Br2ClO4S
2-Methoxy-6-(2-thiophen-2-yl-vinyl)-benzoic acid methyl ester chemical structure, C15H14O3S, CAS 1171924-45-0
2-Methoxy-6-(2-thiophen-2-yl-vinyl)-benzoic acid methyl ester
CAS 1171924-45-0C15H14O3S
2,4-Dihydroxy-6-[2-(5-iodo-thiophen-2-yl)-vinyl]-benzoic acid ethyl ester chemical structure, C15H13IO4S, CAS 365543-01-7
2,4-Dihydroxy-6-[2-(5-iodo-thiophen-2-yl)-vinyl]-benzoic acid ethyl ester
CAS 365543-01-7C15H13IO4S
2-[2-(5-Chloro-thiophen-2-yl)-vinyl]-6-methoxy-benzoic acid methyl ester chemical structure, C15H13ClO3S, CAS 365542-86-5
2-[2-(5-Chloro-thiophen-2-yl)-vinyl]-6-methoxy-benzoic acid methyl ester
CAS 365542-86-5C15H13ClO3S
2-Acetoxy-6-[2-(5-bromo-thiophen-2-yl)-vinyl]-benzoic acid ethyl ester chemical structure, C17H15BrO4S, CAS 365543-05-1
2-Acetoxy-6-[2-(5-bromo-thiophen-2-yl)-vinyl]-benzoic acid ethyl ester
CAS 365543-05-1C17H15BrO4S
(E)-4-(2-(Thiophen-2-yl)vinyl)benzenesulfonamide chemical structure, C12H11NO2S2, CAS 1259295-44-7
(E)-4-(2-(Thiophen-2-yl)vinyl)benzenesulfonamide
CAS 1259295-44-7C12H11NO2S2
1-{4-[2-(Thiophen-2-yl)ethenyl]phenyl}ethan-1-one chemical structure, C14H12OS, CAS 62827-84-3
1-{4-[2-(Thiophen-2-yl)ethenyl]phenyl}ethan-1-one
CAS 62827-84-3C14H12OS