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Murcko scaffold

Ring system with 4 rings and 22 atoms

33 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 22
Chemicals: 33
With full pages: 3

Scaffold SMILES

O=C(Nc1ccccc1)c1cc2cc3c(nc2s1)CCNC3

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1ccccc1)c1cc2cc3c(nc2s1)CCNC3

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 33 of 33 chemicals

6-Acetyl-3-amino-N-(3-cyanophenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C21H16F3N5O2S, CAS 664999-49-9

6-Acetyl-3-amino-N-(3-cyanophenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 664999-49-9C₂₁H₁₆F₃N₅O₂S

3-Amino-N-(4-chlorophenyl)-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C18H17ClN4OS, CAS 371222-56-9

3-Amino-N-(4-chlorophenyl)-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 371222-56-9C₁₈H₁₇ClN₄OS

3-Amino-N-(2,6-dichlorophenyl)-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C18H16Cl2N4OS, CAS 387831-32-5

3-Amino-N-(2,6-dichlorophenyl)-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 387831-32-5C₁₈H₁₆Cl₂N₄OS

Methyl 2-{[(3-amino-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridin-2-yl)carbonyl]amino}-4,5-dimethoxybenzoate chemical structure, C22H24N4O5S, CAS 674800-53-4

Methyl 2-{[(3-amino-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridin-2-yl)carbonyl]amino}-4,5-dimethoxybenzoate

CAS 674800-53-4C₂₂H₂₄N₄O₅S

3-Amino-6-methyl-N-[4-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C19H17F3N4OS, CAS 697246-10-9

3-Amino-6-methyl-N-[4-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 697246-10-9C₁₉H₁₇F₃N₄OS

N-(4-Acetylphenyl)-3-amino-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C20H20N4O2S, CAS 697246-11-0

N-(4-Acetylphenyl)-3-amino-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 697246-11-0C₂₀H₂₀N₄O₂S

3-Amino-N-(2-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C19H20N4O2S, CAS 697246-12-1

3-Amino-N-(2-methoxyphenyl)-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 697246-12-1C₁₉H₂₀N₄O₂S

3-Amino-N-[4-(dimethylamino)phenyl]-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C20H23N5OS, CAS 697246-13-2

3-Amino-N-[4-(dimethylamino)phenyl]-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 697246-13-2C₂₀H₂₃N₅OS

3-Amino-N-(3-cyanophenyl)-6-methyl-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C19H17N5OS, CAS 697246-14-3

3-Amino-N-(3-cyanophenyl)-6-methyl-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 697246-14-3C₁₉H₁₇N₅OS

3-Amino-N-(4-chloro-2-fluorophenyl)-6-methyl-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C18H16ClFN4OS, CAS 698977-22-9

3-Amino-N-(4-chloro-2-fluorophenyl)-6-methyl-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 698977-22-9C₁₈H₁₆ClFN₄OS

3-Amino-6-methyl-N-[2-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C19H17F3N4OS, CAS 698977-32-1

3-Amino-6-methyl-N-[2-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 698977-32-1C₁₉H₁₇F₃N₄OS

3-Amino-N-[4-(diethylamino)phenyl]-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C22H27N5OS, CAS 698978-29-9

3-Amino-N-[4-(diethylamino)phenyl]-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 698978-29-9C₂₂H₂₇N₅OS

3-Amino-N-(4-fluoro-2-methylphenyl)-6-methyl-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C19H19FN4OS, CAS 698978-38-0

3-Amino-N-(4-fluoro-2-methylphenyl)-6-methyl-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 698978-38-0C₁₉H₁₉FN₄OS

3-Amino-6-ethyl-N-(2-(trifluoromethoxy)phenyl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C20H19F3N4O2S, CAS 704871-77-2

3-Amino-6-ethyl-N-(2-(trifluoromethoxy)phenyl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 704871-77-2C₂₀H₁₉F₃N₄O₂S

6-Acetyl-3-amino-N-(2-fluorophenyl)-4-(trifluoromethyl)-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C20H16F4N4O2S, CAS 704876-17-5

6-Acetyl-3-amino-N-(2-fluorophenyl)-4-(trifluoromethyl)-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 704876-17-5C₂₀H₁₆F₄N₄O₂S

6-Acetyl-3-amino-N-(3-fluorophenyl)-4-(trifluoromethyl)-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C20H16F4N4O2S, CAS 704876-19-7

6-Acetyl-3-amino-N-(3-fluorophenyl)-4-(trifluoromethyl)-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 704876-19-7C₂₀H₁₆F₄N₄O₂S

6-Acetyl-3-amino-N-[4-(trifluoromethoxy)phenyl]-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C21H16F6N4O3S, CAS 704876-21-1

6-Acetyl-3-amino-N-[4-(trifluoromethoxy)phenyl]-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 704876-21-1C₂₁H₁₆F₆N₄O₃S

6-Acetyl-3-amino-N-(2-chlorophenyl)-4-(trifluoromethyl)-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C20H16ClF3N4O2S, CAS 727661-18-9

6-Acetyl-3-amino-N-(2-chlorophenyl)-4-(trifluoromethyl)-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 727661-18-9C₂₀H₁₆ClF₃N₄O₂S

6-Acetyl-3-amino-N-(4-fluorophenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C20H16F4N4O2S, CAS 727664-47-3

6-Acetyl-3-amino-N-(4-fluorophenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 727664-47-3C₂₀H₁₆F₄N₄O₂S

6-Acetyl-3-amino-N-(2-methoxyphenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C21H19F3N4O3S, CAS 727679-32-5

6-Acetyl-3-amino-N-(2-methoxyphenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 727679-32-5C₂₁H₁₉F₃N₄O₃S

6-Acetyl-3-amino-N-(4-chloro-2-fluorophenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C20H15ClF4N4O2S, CAS 727683-73-0

6-Acetyl-3-amino-N-(4-chloro-2-fluorophenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 727683-73-0C₂₀H₁₅ClF₄N₄O₂S

3-Amino-N-(3-fluorophenyl)-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C18H17FN4OS, CAS 371951-94-9

3-Amino-N-(3-fluorophenyl)-6-methyl-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 371951-94-9C₁₈H₁₇FN₄OS

3-Amino-6-isopropyl-N-(4-methoxyphenyl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C21H24N4O2S, CAS 728000-33-7

3-Amino-6-isopropyl-N-(4-methoxyphenyl)-5,6,7,8-tetrahydrothieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 728000-33-7C₂₁H₂₄N₄O₂S

3-Amino-6-propan-2-yl-N-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide chemical structure, C21H21F3N4O2S, CAS 728025-83-0

3-Amino-6-propan-2-yl-N-[4-(trifluoromethoxy)phenyl]-7,8-dihydro-5H-thieno[2,3-b][1,6]naphthyridine-2-carboxamide

CAS 728025-83-0C₂₁H₂₁F₃N₄O₂S