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Murcko scaffold

Ring system with 4 rings and 23 atoms

39 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
23
Chemicals
39
With full pages
3
Scaffold SMILES

O=C(Nc1ccccc1)c1cc2c(=O)n3ccccc3nc2s1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(Nc1ccccc1)c1cc2c(=O)n3ccccc3nc2s1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 39 of 39 chemicals

9-Methyl-4-oxo-N-(m-tolyl)-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C19H15N3O2S, CAS 689744-68-1
9-Methyl-4-oxo-N-(m-tolyl)-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 689744-68-1C19H15N3O2S
9-Methyl-4-oxo-N-phenyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C18H13N3O2S, CAS 690252-62-1
9-Methyl-4-oxo-N-phenyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690252-62-1C18H13N3O2S
4H-Pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide, N-[2-(methylthio)phenyl]-4-oxo- chemical structure, C18H13N3O2S2, CAS 519050-47-6
4H-Pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide, N-[2-(methylthio)phenyl]-4-oxo-
CAS 519050-47-6C18H13N3O2S2
N-(2-Methoxy-5-methylphenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C20H17N3O3S, CAS 690252-09-6
N-(2-Methoxy-5-methylphenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690252-09-6C20H17N3O3S
N-(3-Acetylphenyl)-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C19H13N3O3S, CAS 690251-44-6
N-(3-Acetylphenyl)-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690251-44-6C19H13N3O3S
N-(4-Bromo-3-methylphenyl)-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C18H12BrN3O2S, CAS 690251-57-1
N-(4-Bromo-3-methylphenyl)-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690251-57-1C18H12BrN3O2S
N-(3-Chloro-4-fluorophenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C18H11ClFN3O2S, CAS 689745-42-4
N-(3-Chloro-4-fluorophenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 689745-42-4C18H11ClFN3O2S
N-(2,4-Difluorophenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C18H11F2N3O2S, CAS 689745-49-1
N-(2,4-Difluorophenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 689745-49-1C18H11F2N3O2S
N-(3-Fluorophenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C18H12FN3O2S, CAS 690252-40-5
N-(3-Fluorophenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690252-40-5C18H12FN3O2S
N-(3,4-Difluorophenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C18H11F2N3O2S, CAS 689745-56-0
N-(3,4-Difluorophenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 689745-56-0C18H11F2N3O2S
N-(4-Bromo-2-methylphenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C19H14BrN3O2S, CAS 690252-57-4
N-(4-Bromo-2-methylphenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690252-57-4C19H14BrN3O2S
N-Mesityl-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C21H19N3O2S, CAS 690252-81-4
N-Mesityl-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690252-81-4C21H19N3O2S
N-(2,5-Dimethylphenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C20H17N3O2S, CAS 690253-24-8
N-(2,5-Dimethylphenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690253-24-8C20H17N3O2S
N-(2,5-Difluorophenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C18H11F2N3O2S, CAS 690253-58-8
N-(2,5-Difluorophenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690253-58-8C18H11F2N3O2S
N-Butyl-4-oxo-N-phenyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C21H19N3O2S, CAS 690250-26-1
N-Butyl-4-oxo-N-phenyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690250-26-1C21H19N3O2S
N-(2,3-Dichlorophenyl)-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C17H9Cl2N3O2S, CAS 690250-90-9
N-(2,3-Dichlorophenyl)-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690250-90-9C17H9Cl2N3O2S
N-(3-Chloro-2-methylphenyl)-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C18H12ClN3O2S, CAS 690251-08-2
N-(3-Chloro-2-methylphenyl)-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690251-08-2C18H12ClN3O2S
N-(4-Isopropylphenyl)-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C20H17N3O2S, CAS 690251-46-8
N-(4-Isopropylphenyl)-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690251-46-8C20H17N3O2S
N-(3,5-Dimethylphenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C20H17N3O2S, CAS 690251-89-9
N-(3,5-Dimethylphenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690251-89-9C20H17N3O2S
N-(3-Methoxyphenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C19H15N3O3S, CAS 689745-77-5
N-(3-Methoxyphenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 689745-77-5C19H15N3O3S
N-(4-Ethylphenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C20H17N3O2S, CAS 690252-58-5
N-(4-Ethylphenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690252-58-5C20H17N3O2S
N-(4-Isopropylphenyl)-9-methyl-4-oxo-N-propyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C24H25N3O2S, CAS 690253-03-3
N-(4-Isopropylphenyl)-9-methyl-4-oxo-N-propyl-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690253-03-3C24H25N3O2S
N-(3-Chloro-4-methylphenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C19H14ClN3O2S, CAS 690253-21-5
N-(3-Chloro-4-methylphenyl)-9-methyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690253-21-5C19H14ClN3O2S
9-Methyl-N-(3-nitrophenyl)-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide chemical structure, C18H12N4O4S, CAS 690253-38-4
9-Methyl-N-(3-nitrophenyl)-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-2-carboxamide
CAS 690253-38-4C18H12N4O4S