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Murcko scaffold

Ring system with 4 rings and 23 atoms

38 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 23
Chemicals: 38
With full pages: 3

Scaffold SMILES

O=C(Nc1ccccc1)c1cc2cc3c(nc2s1)CCCC3=O

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1ccccc1)c1cc2cc3c(nc2s1)CCCC3=O

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 38 of 38 chemicals

3-Amino-4-ethyl-N-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C23H25N3O3S, CAS 670271-35-9

3-Amino-4-ethyl-N-(4-methoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 670271-35-9C₂₃H₂₅N₃O₃S

3-Amino-4-ethyl-N-(3-methoxyphenyl)-7,7-dimethyl-5-oxo-6,8-dihydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C23H25N3O3S, CAS 670271-36-0

3-Amino-4-ethyl-N-(3-methoxyphenyl)-7,7-dimethyl-5-oxo-6,8-dihydrothieno[2,3-b]quinoline-2-carboxamide

CAS 670271-36-0C₂₃H₂₅N₃O₃S

3-Amino-4-ethyl-N-(4-fluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C22H22FN3O2S, CAS 670271-38-2

3-Amino-4-ethyl-N-(4-fluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 670271-38-2C₂₂H₂₂FN₃O₂S

3-Amino-4-ethyl-N-(2-fluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C22H22FN3O2S, CAS 670271-42-8

3-Amino-4-ethyl-N-(2-fluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 670271-42-8C₂₂H₂₂FN₃O₂S

3-Amino-N-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C19H17N3O3S, CAS 370851-68-6

3-Amino-N-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 370851-68-6C₁₉H₁₇N₃O₃S

3-Amino-N-mesityl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C21H21N3O2S, CAS 496796-46-4

3-Amino-N-mesityl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 496796-46-4C₂₁H₂₁N₃O₂S

3-Amino-N-(3-methoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C21H21N3O3S, CAS 489398-03-0

3-Amino-N-(3-methoxyphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 489398-03-0C₂₁H₂₁N₃O₃S

3-Amino-N-(2,4-dimethoxyphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H19N3O4S, CAS 780792-90-7

3-Amino-N-(2,4-dimethoxyphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 780792-90-7C₂₀H₁₉N₃O₄S

3-Amino-N-(2-chlorophenyl)-7,7-dimethyl-5-oxo-6,8-dihydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H18ClN3O2S, CAS 442557-76-8

3-Amino-N-(2-chlorophenyl)-7,7-dimethyl-5-oxo-6,8-dihydrothieno[2,3-b]quinoline-2-carboxamide

CAS 442557-76-8C₂₀H₁₈ClN₃O₂S

3-Amino-N-(3-chloro-2-methylphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C21H20ClN3O2S, CAS 383892-37-3

3-Amino-N-(3-chloro-2-methylphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 383892-37-3C₂₁H₂₀ClN₃O₂S

3-Amino-N-(4-chlorophenyl)-7,7-dimethyl-5-oxo-6,8-dihydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H18ClN3O2S, CAS 384358-02-5

3-Amino-N-(4-chlorophenyl)-7,7-dimethyl-5-oxo-6,8-dihydrothieno[2,3-b]quinoline-2-carboxamide

CAS 384358-02-5C₂₀H₁₈ClN₃O₂S

3-Amino-5-oxo-N-(m-tolyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C19H17N3O2S, CAS 369394-58-1

3-Amino-5-oxo-N-(m-tolyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 369394-58-1C₁₉H₁₇N₃O₂S

3-Amino-N-(4-bromophenyl)-7,7-dimethyl-5-oxo-6,8-dihydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H18BrN3O2S, CAS 299170-07-3

3-Amino-N-(4-bromophenyl)-7,7-dimethyl-5-oxo-6,8-dihydrothieno[2,3-b]quinoline-2-carboxamide

CAS 299170-07-3C₂₀H₁₈BrN₃O₂S

3-Amino-7,7-dimethyl-N-(2-methylphenyl)-5-oxo-6,8-dihydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C21H21N3O2S, CAS 370847-69-1

3-Amino-7,7-dimethyl-N-(2-methylphenyl)-5-oxo-6,8-dihydrothieno[2,3-b]quinoline-2-carboxamide

CAS 370847-69-1C₂₁H₂₁N₃O₂S

3-Amino-N-(4-fluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H18FN3O2S, CAS 442556-63-0

3-Amino-N-(4-fluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 442556-63-0C₂₀H₁₈FN₃O₂S

3-Amino-N-(3,4-dimethylphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H19N3O2S, CAS 442556-27-6

3-Amino-N-(3,4-dimethylphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 442556-27-6C₂₀H₁₉N₃O₂S

3-Amino-N-(3-chloro-2-methylphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C19H16ClN3O2S, CAS 442556-59-4

3-Amino-N-(3-chloro-2-methylphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 442556-59-4C₁₉H₁₆ClN₃O₂S

3-Amino-N-(2-ethylphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H19N3O2S, CAS 442556-56-1

3-Amino-N-(2-ethylphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 442556-56-1C₂₀H₁₉N₃O₂S

3-Amino-5-oxo-N-(p-tolyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C19H17N3O2S, CAS 442556-68-5

3-Amino-5-oxo-N-(p-tolyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 442556-68-5C₁₉H₁₇N₃O₂S

3-Amino-N-mesityl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C23H25N3O2S, CAS 442556-66-3

3-Amino-N-mesityl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 442556-66-3C₂₃H₂₅N₃O₂S

3-Amino-N-(2-ethylphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C22H23N3O2S, CAS 488858-36-2

3-Amino-N-(2-ethylphenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 488858-36-2C₂₂H₂₃N₃O₂S

3-Amino-N-(2,6-dimethylphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H19N3O2S, CAS 442556-65-2

3-Amino-N-(2,6-dimethylphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 442556-65-2C₂₀H₁₉N₃O₂S

3-Amino-N-(3-chloro-4-methylphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C19H16ClN3O2S, CAS 442556-64-1

3-Amino-N-(3-chloro-4-methylphenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 442556-64-1C₁₉H₁₆ClN₃O₂S

3-Amino-N-(3-chlorophenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C18H14ClN3O2S, CAS 383895-84-9

3-Amino-N-(3-chlorophenyl)-5-oxo-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 383895-84-9C₁₈H₁₄ClN₃O₂S