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Murcko scaffold

Ring system with 4 rings and 22 atoms

66 chemicals on CompoundList share this ring system.

Rings: 4
Scaffold atoms: 22
Chemicals: 66
With full pages: 10

Scaffold SMILES

O=C(Nc1ccccc1)c1cc2cc3c(nc2s1)CCCC3

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=C(Nc1ccccc1)c1cc2cc3c(nc2s1)CCCC3

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 66 chemicals

3-Amino-N-(2,3-DI-ME-PH)-5,6,7,8-tetrahydrothieno(2,3-B)quinoline-2-carboxamide chemical structure, C20H21N3OS, CAS 309741-93-3

3-Amino-N-(2,3-DI-ME-PH)-5,6,7,8-tetrahydrothieno(2,3-B)quinoline-2-carboxamide

CAS 309741-93-3C₂₀H₂₁N₃OS

3-Amino-N-(3-methylphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C19H19N3OS, CAS 354793-63-8

3-Amino-N-(3-methylphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 354793-63-8C₁₉H₁₉N₃OS

3-Amino-N-(4-fluorophenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C18H16FN3OS, CAS 428451-61-0

3-Amino-N-(4-fluorophenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 428451-61-0C₁₈H₁₆FN₃OS

3-Amino-N-(4-CL-phenyl)-5,6,7,8-tetrahydrothieno(2,3-B)quinoline-2-carboxamide chemical structure, C18H16ClN3OS, CAS 441743-08-4

3-Amino-N-(4-CL-phenyl)-5,6,7,8-tetrahydrothieno(2,3-B)quinoline-2-carboxamide

CAS 441743-08-4C₁₈H₁₆ClN₃OS

3-Amino-N-[4-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C19H16F3N3O2S, CAS 442669-37-6

3-Amino-N-[4-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 442669-37-6C₁₉H₁₆F₃N₃O₂S

3-Amino-N-[2-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C19H16F3N3O2S, CAS 445382-67-2

3-Amino-N-[2-(trifluoromethoxy)phenyl]-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 445382-67-2C₁₉H₁₆F₃N₃O₂S

3-Amino-N-(4-methylphenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H18F3N3OS, CAS 626227-84-7

3-Amino-N-(4-methylphenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 626227-84-7C₂₀H₁₈F₃N₃OS

3-Amino-N-(2,4-difluorophenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C19H14F5N3OS, CAS 626227-71-2

3-Amino-N-(2,4-difluorophenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 626227-71-2C₁₉H₁₄F₅N₃OS

3-Amino-N-(2,4-dimethoxyphenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C21H20F3N3O3S, CAS 626221-70-3

3-Amino-N-(2,4-dimethoxyphenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 626221-70-3C₂₁H₂₀F₃N₃O₃S

3-Amino-N-(5-chloro-2-methylphenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H17ClF3N3OS, CAS 626227-74-5

3-Amino-N-(5-chloro-2-methylphenyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 626227-74-5C₂₀H₁₇ClF₃N₃OS

3-Amino-N-[2-chloro-5-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydrothieno[2,3-B]quinoline-2-carboxamide chemical structure, C19H15ClF3N3OS, CAS 400864-41-7

3-Amino-N-[2-chloro-5-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydrothieno[2,3-B]quinoline-2-carboxamide

CAS 400864-41-7C₁₉H₁₅ClF₃N₃OS

3-Amino-N-(4-methoxyphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C19H19N3O2S, CAS 340813-02-7

3-Amino-N-(4-methoxyphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 340813-02-7C₁₉H₁₉N₃O₂S

3-Amino-N-(2,5-dimethoxyphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H21N3O3S, CAS 6418-15-1

3-Amino-N-(2,5-dimethoxyphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 6418-15-1C₂₀H₂₁N₃O₃S

3-Amino-N-(4-methylphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C19H19N3OS, CAS 441718-28-1

3-Amino-N-(4-methylphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 441718-28-1C₁₉H₁₉N₃OS

3-Amino-N-(3,4-DI-CL-PH)-5,6,7,8-tetrahydrothieno(2,3-B)quinoline-2-carboxamide chemical structure, C18H15Cl2N3OS, CAS 428450-40-2

3-Amino-N-(3,4-DI-CL-PH)-5,6,7,8-tetrahydrothieno(2,3-B)quinoline-2-carboxamide

CAS 428450-40-2C₁₈H₁₅Cl₂N₃OS

3-Amino-N-(2-fluorophenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C18H16FN3OS, CAS 333415-84-2

3-Amino-N-(2-fluorophenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 333415-84-2C₁₈H₁₆FN₃OS

3-Amino-N-(4-nitrophenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C18H16N4O3S, CAS 361198-72-3

3-Amino-N-(4-nitrophenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 361198-72-3C₁₈H₁₆N₄O₃S

N-(4-Acetylphenyl)-3-amino-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C22H23N3O2S, CAS 445269-19-2

N-(4-Acetylphenyl)-3-amino-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 445269-19-2C₂₂H₂₃N₃O₂S

3-Amino-6-ethyl-N-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C23H27N3O4S, CAS 445269-18-1

3-Amino-6-ethyl-N-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 445269-18-1C₂₃H₂₇N₃O₄S

3-Amino-N-(4-bromo-2-methylphenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C21H22BrN3OS, CAS 445268-90-6

3-Amino-N-(4-bromo-2-methylphenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 445268-90-6C₂₁H₂₂BrN₃OS

3-Amino-N-(4-chlorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H20ClN3OS, CAS 625370-24-3

3-Amino-N-(4-chlorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 625370-24-3C₂₀H₂₀ClN₃OS

3-Amino-N-(2,5-dichlorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H19Cl2N3OS, CAS 445268-85-9

3-Amino-N-(2,5-dichlorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 445268-85-9C₂₀H₁₉Cl₂N₃OS

3-Amino-N-(2-ethoxyphenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C22H25N3O2S, CAS 445268-86-0

3-Amino-N-(2-ethoxyphenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 445268-86-0C₂₂H₂₅N₃O₂S

3-Amino-N-(2,4-dichlorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide chemical structure, C20H19Cl2N3OS, CAS 627057-31-2

3-Amino-N-(2,4-dichlorophenyl)-6-ethyl-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide

CAS 627057-31-2C₂₀H₁₉Cl₂N₃OS