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Murcko scaffold

Ring system with 3 rings and 21 atoms

39 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
21
Chemicals
39
With full pages
2
Scaffold SMILES

O=C(CSc1nnnn1-c1ccccc1)Nc1nccs1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(CSc1nnnn1-c1ccccc1)Nc1nccs1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 39 of 39 chemicals

2-[1-(3-Chloro-4-methyl-phenyl)-1H-tetrazol-5-ylsulfanyl]-N-thiazol-2-yl-acetamide chemical structure, C13H11ClN6OS2, CAS 370092-42-5
2-[1-(3-Chloro-4-methyl-phenyl)-1H-tetrazol-5-ylsulfanyl]-N-thiazol-2-yl-acetamide
CAS 370092-42-5C13H11ClN6OS2
2-[(1-Mesityl-1H-tetraazol-5-yl)sulfanyl]-N-(1,3-thiazol-2-yl)acetamide chemical structure, C15H16N6OS2, CAS 428838-84-0
2-[(1-Mesityl-1H-tetraazol-5-yl)sulfanyl]-N-(1,3-thiazol-2-yl)acetamide
CAS 428838-84-0C15H16N6OS2
2-((1-(4-Fluorophenyl)-1H-tetrazol-5-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C12H9FN6OS2, CAS 833428-14-1
2-((1-(4-Fluorophenyl)-1H-tetrazol-5-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 833428-14-1C12H9FN6OS2
N-(5-Methyl-1,3-thiazol-2-yl)-2-(1-phenyltetrazol-5-yl)sulfanylacetamide chemical structure, C13H12N6OS2, CAS 700855-37-4
N-(5-Methyl-1,3-thiazol-2-yl)-2-(1-phenyltetrazol-5-yl)sulfanylacetamide
CAS 700855-37-4C13H12N6OS2
Ethyl 4-methyl-2-({[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]acetyl}amino)-1,3-thiazole-5-carboxylate chemical structure, C16H16N6O3S2, CAS 433308-13-5
Ethyl 4-methyl-2-({[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]acetyl}amino)-1,3-thiazole-5-carboxylate
CAS 433308-13-5C16H16N6O3S2
N-(4-tert-Butyl-1,3-thiazol-2-yl)-2-(1-phenyltetrazol-5-yl)sulfanylacetamide chemical structure, C16H18N6OS2, CAS 824981-01-3
N-(4-tert-Butyl-1,3-thiazol-2-yl)-2-(1-phenyltetrazol-5-yl)sulfanylacetamide
CAS 824981-01-3C16H18N6OS2
2-[1-(4-Methylphenyl)tetrazol-5-yl]sulfanyl-N-(1,3-thiazol-2-yl)acetamide chemical structure, C13H12N6OS2, CAS 725707-25-5
2-[1-(4-Methylphenyl)tetrazol-5-yl]sulfanyl-N-(1,3-thiazol-2-yl)acetamide
CAS 725707-25-5C13H12N6OS2
2-[1-(4-Chlorophenyl)tetrazol-5-yl]sulfanyl-N-(1,3-thiazol-2-yl)acetamide chemical structure, C12H9ClN6OS2, CAS 853750-97-7
2-[1-(4-Chlorophenyl)tetrazol-5-yl]sulfanyl-N-(1,3-thiazol-2-yl)acetamide
CAS 853750-97-7C12H9ClN6OS2
N-(5-Nitro-1,3-thiazol-2-yl)-2-(1-phenyltetrazol-5-yl)sulfanylacetamide chemical structure, C12H9N7O3S2, CAS 433316-90-6
N-(5-Nitro-1,3-thiazol-2-yl)-2-(1-phenyltetrazol-5-yl)sulfanylacetamide
CAS 433316-90-6C12H9N7O3S2
2-(1-Phenyltetrazol-5-yl)sulfanyl-N-(1,3-thiazol-2-yl)propanamide chemical structure, C13H12N6OS2, CAS 312523-48-1
2-(1-Phenyltetrazol-5-yl)sulfanyl-N-(1,3-thiazol-2-yl)propanamide
CAS 312523-48-1C13H12N6OS2
Ethyl 4-methyl-2-({2-[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]butanoyl}amino)-1,3-thiazole-5-carboxylate chemical structure, C18H20N6O3S2, CAS 528565-39-1
Ethyl 4-methyl-2-({2-[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]butanoyl}amino)-1,3-thiazole-5-carboxylate
CAS 528565-39-1C18H20N6O3S2
2-[(1-Phenyl-1H-tetrazol-5-yl)sulfanyl]-N-(1,3-thiazol-2-yl)butanamide chemical structure, C14H14N6OS2, CAS 701222-64-2
2-[(1-Phenyl-1H-tetrazol-5-yl)sulfanyl]-N-(1,3-thiazol-2-yl)butanamide
CAS 701222-64-2C14H14N6OS2
2-[1-(2-Chlorophenyl)tetrazol-5-yl]sulfanyl-N-(1,3-thiazol-2-yl)acetamide chemical structure, C12H9ClN6OS2, CAS 838874-89-8
2-[1-(2-Chlorophenyl)tetrazol-5-yl]sulfanyl-N-(1,3-thiazol-2-yl)acetamide
CAS 838874-89-8C12H9ClN6OS2
2-((1-(2-Methoxyphenyl)-1H-tetrazol-5-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C13H12N6O2S2, CAS 838880-98-1
2-((1-(2-Methoxyphenyl)-1H-tetrazol-5-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 838880-98-1C13H12N6O2S2
N-(1,3-Thiazol-2-yl)-2-[1-[3-(trifluoromethyl)phenyl]tetrazol-5-yl]sulfanylacetamide chemical structure, C13H9F3N6OS2, CAS 838897-17-9
N-(1,3-Thiazol-2-yl)-2-[1-[3-(trifluoromethyl)phenyl]tetrazol-5-yl]sulfanylacetamide
CAS 838897-17-9C13H9F3N6OS2
2-[1-(2-Fluorophenyl)tetrazol-5-yl]sulfanyl-N-(1,3-thiazol-2-yl)acetamide chemical structure, C12H9FN6OS2, CAS 847240-66-8
2-[1-(2-Fluorophenyl)tetrazol-5-yl]sulfanyl-N-(1,3-thiazol-2-yl)acetamide
CAS 847240-66-8C12H9FN6OS2
2-{[1-(2-Methylphenyl)-1H-tetrazol-5-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide chemical structure, C13H12N6OS2, CAS 839682-66-5
2-{[1-(2-Methylphenyl)-1H-tetrazol-5-yl]sulfanyl}-N-(1,3-thiazol-2-yl)acetamide
CAS 839682-66-5C13H12N6OS2
2-[1-(3-Methylphenyl)tetrazol-5-yl]sulfanyl-N-(1,3-thiazol-2-yl)acetamide chemical structure, C13H12N6OS2, CAS 874467-40-0
2-[1-(3-Methylphenyl)tetrazol-5-yl]sulfanyl-N-(1,3-thiazol-2-yl)acetamide
CAS 874467-40-0C13H12N6OS2
2-((1-(2-Ethylphenyl)-1H-tetrazol-5-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C14H14N6OS2, CAS 874467-41-1
2-((1-(2-Ethylphenyl)-1H-tetrazol-5-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 874467-41-1C14H14N6OS2
2-((1-(2,5-Dimethylphenyl)-1H-tetrazol-5-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C14H14N6OS2, CAS 874467-42-2
2-((1-(2,5-Dimethylphenyl)-1H-tetrazol-5-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 874467-42-2C14H14N6OS2
2-((1-(4-Isopropylphenyl)-1H-tetrazol-5-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C15H16N6OS2, CAS 878699-71-9
2-((1-(4-Isopropylphenyl)-1H-tetrazol-5-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 878699-71-9C15H16N6OS2
2-((1-(2-Ethoxyphenyl)-1H-tetrazol-5-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C14H14N6O2S2, CAS 874467-68-2
2-((1-(2-Ethoxyphenyl)-1H-tetrazol-5-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 874467-68-2C14H14N6O2S2
2-((1-(5-Chloro-2-methylphenyl)-1H-tetrazol-5-yl)thio)-N-(thiazol-2-yl)acetamide chemical structure, C13H11ClN6OS2, CAS 874467-69-3
2-((1-(5-Chloro-2-methylphenyl)-1H-tetrazol-5-yl)thio)-N-(thiazol-2-yl)acetamide
CAS 874467-69-3C13H11ClN6OS2
N-(1,3-Thiazol-2-yl)-2-({1-[2-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}sulfanyl)acetamide chemical structure, C13H9F3N6OS2, CAS 878699-84-4
N-(1,3-Thiazol-2-yl)-2-({1-[2-(trifluoromethyl)phenyl]-1H-tetrazol-5-yl}sulfanyl)acetamide
CAS 878699-84-4C13H9F3N6OS2