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Murcko scaffold

Ring system with 3 rings and 19 atoms

31 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 19
Chemicals: 31
With full pages: 3

Scaffold SMILES

O=c1cc(N2CCNCC2)cnn1-c1ccccc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold O=c1cc(N2CCNCC2)cnn1-c1ccccc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 31 of 31 chemicals

4-Chloro-5-(4-methylpiperazin-1-yl)-2-phenylpyridazin-3(2H)-one chemical structure, C15H17ClN4O, CAS 302803-63-0

4-Chloro-5-(4-methylpiperazin-1-yl)-2-phenylpyridazin-3(2H)-one

CAS 302803-63-0C₁₅H₁₇ClN₄O

4-Chloro-2-phenyl-5-(piperazin-1-yl)-2,3-dihydropyridazin-3-one chemical structure, C14H15ClN4O, CAS 153276-35-8

4-Chloro-2-phenyl-5-(piperazin-1-yl)-2,3-dihydropyridazin-3-one

CAS 153276-35-8C₁₄H₁₅ClN₄O

4-Chloro-5-[4-(2-hydroxyethyl)piperazin-1-yl]-2-phenylpyridazin-3(2H)-one chemical structure, C16H19ClN4O2, CAS 695219-27-3

4-Chloro-5-[4-(2-hydroxyethyl)piperazin-1-yl]-2-phenylpyridazin-3(2H)-one

CAS 695219-27-3C₁₆H₁₉ClN₄O₂

4-Bromo-5-(4-methylpiperazin-1-yl)-2-phenylpyridazin-3(2H)-one chemical structure, C15H17BrN4O, CAS 698976-92-0

4-Bromo-5-(4-methylpiperazin-1-yl)-2-phenylpyridazin-3(2H)-one

CAS 698976-92-0C₁₅H₁₇BrN₄O

4-Bromo-2-phenyl-5-(piperazin-1-yl)pyridazin-3(2H)-one chemical structure, C14H15BrN4O, CAS 673490-65-8

4-Bromo-2-phenyl-5-(piperazin-1-yl)pyridazin-3(2H)-one

CAS 673490-65-8C₁₄H₁₅BrN₄O

4-Chloro-5-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]-2-phenylpyridazin-3-one chemical structure, C19H23ClN4O2, CAS 701948-71-2

4-Chloro-5-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]-2-phenylpyridazin-3-one

CAS 701948-71-2C₁₉H₂₃ClN₄O₂

4-Bromo-2-(4-fluorophenyl)-5-(4-methylpiperazino)-3(2H)-pyridazinone chemical structure, C15H16BrFN4O, CAS 338962-47-3

4-Bromo-2-(4-fluorophenyl)-5-(4-methylpiperazino)-3(2H)-pyridazinone

CAS 338962-47-3C₁₅H₁₆BrFN₄O

4-Chloro-2-(3-chlorophenyl)-5-piperazino-3(2H)-pyridazinone chemical structure, C14H14Cl2N4O, CAS 449778-66-9

4-Chloro-2-(3-chlorophenyl)-5-piperazino-3(2H)-pyridazinone

CAS 449778-66-9C₁₄H₁₄Cl₂N₄O

4-Chloro-2-(3-chlorophenyl)-5-(4-methylpiperazino)-3(2H)-pyridazinone chemical structure, C15H16Cl2N4O, CAS 320421-78-1

4-Chloro-2-(3-chlorophenyl)-5-(4-methylpiperazino)-3(2H)-pyridazinone

CAS 320421-78-1C₁₅H₁₆Cl₂N₄O

4-Bromo-5-(4-methylsulfonylpiperazin-1-yl)-2-phenylpyridazin-3-one chemical structure, C15H17BrN4O3S, CAS 674817-56-2

4-Bromo-5-(4-methylsulfonylpiperazin-1-yl)-2-phenylpyridazin-3-one

CAS 674817-56-2C₁₅H₁₇BrN₄O₃S

4-Chloro-5-(4-ethylsulfonylpiperazin-1-yl)-2-phenylpyridazin-3-one chemical structure, C16H19ClN4O3S, CAS 774549-96-1

4-Chloro-5-(4-ethylsulfonylpiperazin-1-yl)-2-phenylpyridazin-3-one

CAS 774549-96-1C₁₆H₁₉ClN₄O₃S

Ethyl 2-(((4-(5-chloro-1-(3-chlorophenyl)-6-oxo-1,6-dihydro-4-pyridazinyl)piperazino)carbothioyl)amino)acetate chemical structure, C19H21Cl2N5O3S, CAS 477867-35-9

Ethyl 2-(((4-(5-chloro-1-(3-chlorophenyl)-6-oxo-1,6-dihydro-4-pyridazinyl)piperazino)carbothioyl)amino)acetate

CAS 477867-35-9C₁₉H₂₁Cl₂N₅O₃S

Ethyl 3-{4-[5-chloro-1-(3-chlorophenyl)-6-oxo-1,6-dihydro-4-pyridazinyl]piperazino}-2-cyanoacrylate chemical structure, C20H19Cl2N5O3, CAS 477867-38-2

Ethyl 3-{4-[5-chloro-1-(3-chlorophenyl)-6-oxo-1,6-dihydro-4-pyridazinyl]piperazino}-2-cyanoacrylate

CAS 477867-38-2C₂₀H₁₉Cl₂N₅O₃

4-Chloro-5-(4-ethylpiperazin-1-yl)-2-phenyl-2,3-dihydropyridazin-3-one chemical structure, C16H19ClN4O, CAS 923127-41-7

4-Chloro-5-(4-ethylpiperazin-1-yl)-2-phenyl-2,3-dihydropyridazin-3-one

CAS 923127-41-7C₁₆H₁₉ClN₄O

4-Chloro-2-(4-chloro-phenyl)-5-(4-methyl-piperazin-1-yl)-2H-pyridazin-3-one chemical structure, C15H16Cl2N4O, CAS 353255-44-4

4-Chloro-2-(4-chloro-phenyl)-5-(4-methyl-piperazin-1-yl)-2H-pyridazin-3-one

CAS 353255-44-4C₁₅H₁₆Cl₂N₄O

4-Chloro-2-phenyl-5-(piperazin-1-yl)-2,3-dihydropyridazin-3-one hydrochloride chemical structure, C14H16Cl2N4O, CAS 1052540-00-7

4-Chloro-2-phenyl-5-(piperazin-1-yl)-2,3-dihydropyridazin-3-one hydrochloride

CAS 1052540-00-7C₁₄H₁₆Cl₂N₄O

Ethyl 4-(4-(ethoxycarbonyl)piperazin-1-yl)-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate chemical structure, C20H24N4O5, CAS 923115-00-8

Ethyl 4-(4-(ethoxycarbonyl)piperazin-1-yl)-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate

CAS 923115-00-8C₂₀H₂₄N₄O₅

Ethyl 4-(4-acetylpiperazin-1-yl)-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate chemical structure, C19H22N4O4, CAS 922095-63-4

Ethyl 4-(4-acetylpiperazin-1-yl)-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate

CAS 922095-63-4C₁₉H₂₂N₄O₄

Ethyl 4-(4-(ethoxycarbonyl)piperazin-1-yl)-6-oxo-1-(o-tolyl)-1,6-dihydropyridazine-3-carboxylate chemical structure, C21H26N4O5, CAS 922014-86-6

Ethyl 4-(4-(ethoxycarbonyl)piperazin-1-yl)-6-oxo-1-(o-tolyl)-1,6-dihydropyridazine-3-carboxylate

CAS 922014-86-6C₂₁H₂₆N₄O₅

Ethyl 4-(4-(2-hydroxyethyl)piperazin-1-yl)-6-oxo-1-(o-tolyl)-1,6-dihydropyridazine-3-carboxylate chemical structure, C20H26N4O4, CAS 922015-11-0

Ethyl 4-(4-(2-hydroxyethyl)piperazin-1-yl)-6-oxo-1-(o-tolyl)-1,6-dihydropyridazine-3-carboxylate

CAS 922015-11-0C₂₀H₂₆N₄O₄

Ethyl 4-(4-acetylpiperazin-1-yl)-6-oxo-1-(o-tolyl)-1,6-dihydropyridazine-3-carboxylate chemical structure, C20H24N4O4, CAS 922120-63-6

Ethyl 4-(4-acetylpiperazin-1-yl)-6-oxo-1-(o-tolyl)-1,6-dihydropyridazine-3-carboxylate

CAS 922120-63-6C₂₀H₂₄N₄O₄

Ethyl 4-(4-(ethoxycarbonyl)piperazin-1-yl)-6-oxo-1-(p-tolyl)-1,6-dihydropyridazine-3-carboxylate chemical structure, C21H26N4O5, CAS 922068-20-0

Ethyl 4-(4-(ethoxycarbonyl)piperazin-1-yl)-6-oxo-1-(p-tolyl)-1,6-dihydropyridazine-3-carboxylate

CAS 922068-20-0C₂₁H₂₆N₄O₅

Ethyl 4-(4-(2-hydroxyethyl)piperazin-1-yl)-6-oxo-1-(p-tolyl)-1,6-dihydropyridazine-3-carboxylate chemical structure, C20H26N4O4, CAS 922068-41-5

Ethyl 4-(4-(2-hydroxyethyl)piperazin-1-yl)-6-oxo-1-(p-tolyl)-1,6-dihydropyridazine-3-carboxylate

CAS 922068-41-5C₂₀H₂₆N₄O₄

Ethyl 4-(4-(ethoxycarbonyl)piperazin-1-yl)-1-(4-fluorophenyl)-6-oxo-1,6-dihydropyridazine-3-carboxylate chemical structure, C20H23FN4O5, CAS 922121-75-3

Ethyl 4-(4-(ethoxycarbonyl)piperazin-1-yl)-1-(4-fluorophenyl)-6-oxo-1,6-dihydropyridazine-3-carboxylate

CAS 922121-75-3C₂₀H₂₃FN₄O₅