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Murcko scaffold

Ring system with 3 rings and 18 atoms

42 chemicals on CompoundList share this ring system.

Rings: 3
Scaffold atoms: 18
Chemicals: 42
With full pages: 4

Scaffold SMILES

c1ccc(N2CCN(c3cccnc3)CC2)cc1

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold

Murcko scaffold c1ccc(N2CCN(c3cccnc3)CC2)cc1

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 42 of 42 chemicals

Piperazine, 1-(4-amino-3-pyridyl)-4-phenyl- chemical structure, C15H18N4, CAS 14549-63-4

Piperazine, 1-(4-amino-3-pyridyl)-4-phenyl-

CAS 14549-63-4C₁₅H₁₈N₄

3-[4-(4-Fluorophenyl)piperazin-1-yl]-5-(trifluoromethyl)pyridine-2-carbonitrile chemical structure, C17H14F4N4, CAS 338759-44-7

3-[4-(4-Fluorophenyl)piperazin-1-yl]-5-(trifluoromethyl)pyridine-2-carbonitrile

CAS 338759-44-7C₁₇H₁₄F₄N₄

5-(Trifluoromethyl)-3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyridine-2-carbonitrile chemical structure, C18H14F6N4, CAS 338791-63-2

5-(Trifluoromethyl)-3-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}pyridine-2-carbonitrile

CAS 338791-63-2C₁₈H₁₄F₆N₄

1-(4-Fluorophenyl)-4-(6-nitropyridin-3-yl)piperazine chemical structure, C15H15FN4O2, CAS 729575-81-9

1-(4-Fluorophenyl)-4-(6-nitropyridin-3-yl)piperazine

CAS 729575-81-9C₁₅H₁₅FN₄O₂

3-[4-(4-Methoxyphenyl)piperazin-1-yl]-5-(trifluoromethyl)pyridine-2-carbonitrile chemical structure, C18H17F3N4O, CAS 338968-21-1

3-[4-(4-Methoxyphenyl)piperazin-1-yl]-5-(trifluoromethyl)pyridine-2-carbonitrile

CAS 338968-21-1C₁₈H₁₇F₃N₄O

1-(2-Chlorophenyl)-4-(6-nitropyridin-3-yl)piperazine chemical structure, C15H15ClN4O2, CAS 852215-88-4

1-(2-Chlorophenyl)-4-(6-nitropyridin-3-yl)piperazine

CAS 852215-88-4C₁₅H₁₅ClN₄O₂

1-(3-Chlorophenyl)-4-(6-nitropyridin-3-yl)piperazine chemical structure, C15H15ClN4O2, CAS 852301-70-3

1-(3-Chlorophenyl)-4-(6-nitropyridin-3-yl)piperazine

CAS 852301-70-3C₁₅H₁₅ClN₄O₂

1-(4-Methoxyphenyl)-4-(6-nitropyridin-3-yl)piperazine chemical structure, C16H18N4O3, CAS 128063-83-2

1-(4-Methoxyphenyl)-4-(6-nitropyridin-3-yl)piperazine

CAS 128063-83-2C₁₆H₁₈N₄O₃

1-[3-[4-(4-Chlorophenyl)piperazino]-5-(trifluoromethyl)-2-pyridinyl]-1-ethanone chemical structure, C18H17ClF3N3O, CAS 900015-68-1

1-[3-[4-(4-Chlorophenyl)piperazino]-5-(trifluoromethyl)-2-pyridinyl]-1-ethanone

CAS 900015-68-1C₁₈H₁₇ClF₃N₃O

Benzenamine,4-[4-(3-pyridinyl)-1-piperazinyl]- chemical structure, C15H18N4, CAS 112940-60-0

Benzenamine,4-[4-(3-pyridinyl)-1-piperazinyl]-

CAS 112940-60-0C₁₅H₁₈N₄

Piperazine,1-(4-nitrophenyl)-4-(3-pyridinyl)- chemical structure, C15H16N4O2, CAS 112940-59-7

Piperazine,1-(4-nitrophenyl)-4-(3-pyridinyl)-

CAS 112940-59-7C₁₅H₁₆N₄O₂

Piperazine, 1-(6-methoxy-3-pyridinyl)-4-(4-nitrophenyl)- chemical structure, C16H18N4O3, CAS 158399-77-0

Piperazine, 1-(6-methoxy-3-pyridinyl)-4-(4-nitrophenyl)-

CAS 158399-77-0C₁₆H₁₈N₄O₃

3-[4-(3-Pyridinyl)-1-piperazinyl]benzenemethanol chemical structure, C16H19N3O, CAS 1400759-70-7

3-[4-(3-Pyridinyl)-1-piperazinyl]benzenemethanol

CAS 1400759-70-7C₁₆H₁₉N₃O

2-Fluoro-3-[4-(3-pyridinyl)-1-piperazinyl]benzenemethanol chemical structure, C16H18FN3O, CAS 1400758-68-0

2-Fluoro-3-[4-(3-pyridinyl)-1-piperazinyl]benzenemethanol

CAS 1400758-68-0C₁₆H₁₈FN₃O

3-(4-Phenylpiperazin-1-yl)pyridine-4-carboxylic acid chemical structure, C16H17N3O2, CAS 1461602-23-2

3-(4-Phenylpiperazin-1-yl)pyridine-4-carboxylic acid

CAS 1461602-23-2C₁₆H₁₇N₃O₂

5-[4-(3-Chlorophenyl)piperazin-1-yl]pyridine-2-carbonitrile chemical structure, C16H15ClN4, CAS 1548507-51-2

5-[4-(3-Chlorophenyl)piperazin-1-yl]pyridine-2-carbonitrile

CAS 1548507-51-2C₁₆H₁₅ClN₄

1-(3-(((tert-Butyldimethylsilyl)oxy)methyl)-2-fluorophenyl)-4-(pyridin-3-yl)piperazine chemical structure, C22H32FN3OSi, CAS 1400756-78-6

1-(3-(((tert-Butyldimethylsilyl)oxy)methyl)-2-fluorophenyl)-4-(pyridin-3-yl)piperazine

CAS 1400756-78-6C₂₂H₃₂FN₃OSi

1-[3-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]phenyl]-4-(3-pyridinyl)piperazine chemical structure, C22H33N3OSi, CAS 1400757-04-1

1-[3-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]phenyl]-4-(3-pyridinyl)piperazine

CAS 1400757-04-1C₂₂H₃₃N₃OSi

Methyl 5-[4-[2-fluoro-3-(hydroxymethyl)phenyl]-1-piperazinyl]-2-pyridinecarboxylate chemical structure, C18H20FN3O3, CAS 1400758-88-4

Methyl 5-[4-[2-fluoro-3-(hydroxymethyl)phenyl]-1-piperazinyl]-2-pyridinecarboxylate

CAS 1400758-88-4C₁₈H₂₀FN₃O₃

5-[4-(2-Methoxyphenyl)piperazin-1-yl]pyridine-2-carbonitrile chemical structure, C17H18N4O, CAS 2741924-40-1

5-[4-(2-Methoxyphenyl)piperazin-1-yl]pyridine-2-carbonitrile

CAS 2741924-40-1C₁₇H₁₈N₄O

5-{4-[3-(Trifluoromethyl)phenyl]piperazin-1-yl}pyridine-2-carbonitrile chemical structure, C17H15F3N4, CAS 2770589-44-9

5-{4-[3-(Trifluoromethyl)phenyl]piperazin-1-yl}pyridine-2-carbonitrile

CAS 2770589-44-9C₁₇H₁₅F₃N₄

5-[4-(3-Methoxyphenyl)piperazin-1-yl]pyridine-2-carbonitrile chemical structure, C17H18N4O, CAS 2741934-74-5

5-[4-(3-Methoxyphenyl)piperazin-1-yl]pyridine-2-carbonitrile

CAS 2741934-74-5C₁₇H₁₈N₄O

1-(2-Methoxyphenyl)-4-[6-(trifluoromethyl)pyridin-3-yl]piperazine chemical structure, C17H18F3N3O, CAS 2741934-73-4

1-(2-Methoxyphenyl)-4-[6-(trifluoromethyl)pyridin-3-yl]piperazine

CAS 2741934-73-4C₁₇H₁₈F₃N₃O

3-[4-(3-Methoxyphenyl)piperazin-1-yl]pyridine-2-carbonitrile chemical structure, C17H18N4O, CAS 2327345-17-3

3-[4-(3-Methoxyphenyl)piperazin-1-yl]pyridine-2-carbonitrile

CAS 2327345-17-3C₁₇H₁₈N₄O