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Murcko scaffold

Spiro[3H-indole-3,3'-pyrrolidin]-2(1H)-one scaffold

110 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
14
Chemicals
110
With full pages
5
Scaffold SMILES

O=C1Nc2ccccc2C12CCNC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Spiro[3H-indole-3,3'-pyrrolidin]-2(1H)-one page
Murcko scaffold O=C1Nc2ccccc2C12CCNC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 48 of 110 chemicals

Spiro(indoline-3,3'-pyrrolidin)-2-one, 1'-ethyl- chemical structure, C13H16N2O, CAS 59022-46-7
Spiro(indoline-3,3'-pyrrolidin)-2-one, 1'-ethyl-
CAS 59022-46-7C13H16N2O
Spiro(3H-indole-3,3'-pyrrolidin)-2(1H)-one, 1'-ethyl-7-methyl-, hydrochloride (1:1) chemical structure, C14H19ClN2O, CAS 59022-47-8
Spiro(3H-indole-3,3'-pyrrolidin)-2(1H)-one, 1'-ethyl-7-methyl-, hydrochloride (1:1)
CAS 59022-47-8C14H19ClN2O
Spiro(indoline-3,3'-pyrrolidin)-2-one, 1'-propyl-, hydrochloride chemical structure, C14H19ClN2O, CAS 59022-48-9
Spiro(indoline-3,3'-pyrrolidin)-2-one, 1'-propyl-, hydrochloride
CAS 59022-48-9C14H19ClN2O
1'-Methylspiro[indoline-3,3'-pyrrolidin]-2-one chemical structure, C12H14N2O, CAS 66859-18-5
1'-Methylspiro[indoline-3,3'-pyrrolidin]-2-one
CAS 66859-18-5C12H14N2O
Spiro[3H-indole-3,3'-pyrrolidin]-2(1H)-one chemical structure, C11H12N2O, CAS 6786-41-0
Spiro[3H-indole-3,3'-pyrrolidin]-2(1H)-one
CAS 6786-41-0C11H12N2O
Elacomine chemical structure, C15H20N2O2, CAS 176300-92-8
Elacomine
CAS 176300-92-8C15H20N2O2
tert-Butyl 2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate chemical structure, C16H20N2O3, CAS 205383-87-5
tert-Butyl 2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate
CAS 205383-87-5C16H20N2O3
Horsfiline, (-)- chemical structure, C13H16N2O2, CAS 136247-72-8
Horsfiline, (-)-
CAS 136247-72-8C13H16N2O2
5-Methoxy-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one chemical structure, C13H16N2O2, CAS 136316-07-9
5-Methoxy-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one
CAS 136316-07-9C13H16N2O2
(+)-Horsfiline chemical structure, C13H16N2O2, CAS 160024-53-3
(+)-Horsfiline
CAS 160024-53-3C13H16N2O2
Coerulescine chemical structure, C12H14N2O, CAS 211305-81-6
Coerulescine
CAS 211305-81-6C12H14N2O
5-Methoxyspiro[indoline-3,3'-pyrrolidin]-2-one chemical structure, C12H14N2O2, CAS 146309-33-3
5-Methoxyspiro[indoline-3,3'-pyrrolidin]-2-one
CAS 146309-33-3C12H14N2O2
1-Ethyl-7-methylspiro[indoline-3,3'-pyrrolidin]-2-one chemical structure, C14H18N2O, CAS 744146-12-1
1-Ethyl-7-methylspiro[indoline-3,3'-pyrrolidin]-2-one
CAS 744146-12-1C14H18N2O
1'-Isobutyrylspiro[indoline-3,3'-pyrrolidin]-2-one chemical structure, C15H18N2O2, CAS 1358808-00-0
1'-Isobutyrylspiro[indoline-3,3'-pyrrolidin]-2-one
CAS 1358808-00-0C15H18N2O2
1'-Pivaloylspiro[indoline-3,3'-pyrrolidin]-2-one chemical structure, C16H20N2O2, CAS 1358457-66-5
1'-Pivaloylspiro[indoline-3,3'-pyrrolidin]-2-one
CAS 1358457-66-5C16H20N2O2
1'-(Methylsulfonyl)spiro[indoline-3,3'-pyrrolidin]-2-one chemical structure, C12H14N2O3S, CAS 1358718-24-7
1'-(Methylsulfonyl)spiro[indoline-3,3'-pyrrolidin]-2-one
CAS 1358718-24-7C12H14N2O3S
N-Isopropyl-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxamide chemical structure, C15H19N3O2, CAS 1358835-91-2
N-Isopropyl-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxamide
CAS 1358835-91-2C15H19N3O2
1'-Isobutyryl-1-methylspiro[indoline-3,3'-pyrrolidin]-2-one chemical structure, C16H20N2O2, CAS 1358414-34-2
1'-Isobutyryl-1-methylspiro[indoline-3,3'-pyrrolidin]-2-one
CAS 1358414-34-2C16H20N2O2
1-Methyl-1'-(methylsulfonyl)spiro[indoline-3,3'-pyrrolidin]-2-one chemical structure, C13H16N2O3S, CAS 1358610-84-0
1-Methyl-1'-(methylsulfonyl)spiro[indoline-3,3'-pyrrolidin]-2-one
CAS 1358610-84-0C13H16N2O3S
N-Isopropyl-1-methyl-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxamide chemical structure, C16H21N3O2, CAS 1358719-49-9
N-Isopropyl-1-methyl-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxamide
CAS 1358719-49-9C16H21N3O2
(3s)-Spiro[indole-3,3'-Pyrrolidin]-2(1H)-One chemical structure, C11H12N2O, CAS 1375083-55-8
(3s)-Spiro[indole-3,3'-Pyrrolidin]-2(1H)-One
CAS 1375083-55-8C11H12N2O
6-Bromo-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one chemical structure, C12H13BrN2O, CAS 1202768-00-0
6-Bromo-1'-methylspiro[indoline-3,3'-pyrrolidin]-2-one
CAS 1202768-00-0C12H13BrN2O
tert-Butyl 5-chloro-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate chemical structure, C16H19ClN2O3, CAS 1172588-22-5
tert-Butyl 5-chloro-2-oxospiro[indoline-3,3'-pyrrolidine]-1'-carboxylate
CAS 1172588-22-5C16H19ClN2O3
1'-(tert-Butoxycarbonyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-4'-carboxylic acid chemical structure, C17H20N2O5, CAS 1251011-21-8
1'-(tert-Butoxycarbonyl)-2-oxospiro[indoline-3,3'-pyrrolidine]-4'-carboxylic acid
CAS 1251011-21-8C17H20N2O5