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Murcko scaffold

1',2'-Dihydrospiro[cyclopentane-1,3'-indole]-2'-one scaffold

13 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
14
Chemicals
13
With full pages
2
Scaffold SMILES

O=C1Nc2ccccc2C12CCCC2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the 1',2'-Dihydrospiro[cyclopentane-1,3'-indole]-2'-one page
Murcko scaffold O=C1Nc2ccccc2C12CCCC2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 13 of 13 chemicals

1',2'-Dihydrospiro[cyclopentane-1,3'-indole]-2'-one chemical structure, C12H13NO, CAS 41058-67-7
1',2'-Dihydrospiro[cyclopentane-1,3'-indole]-2'-one
CAS 41058-67-7C12H13NO
5'-Bromo-1',2'-dihydrospiro[cyclopentane-1,3'-indole]-2'-one chemical structure, C12H12BrNO, CAS 304876-16-2
5'-Bromo-1',2'-dihydrospiro[cyclopentane-1,3'-indole]-2'-one
CAS 304876-16-2C12H12BrNO
6'-Bromospiro[cyclopentane-1,3'-indolin]-2'-one chemical structure, C12H12BrNO, CAS 79208-84-7
6'-Bromospiro[cyclopentane-1,3'-indolin]-2'-one
CAS 79208-84-7C12H12BrNO
6'-Nitrospiro[cyclopentane-1,3'-indolin]-2'-one chemical structure, C12H12N2O3, CAS 52140-53-1
6'-Nitrospiro[cyclopentane-1,3'-indolin]-2'-one
CAS 52140-53-1C12H12N2O3
6'-Aminospiro[cyclopentane-1,3'-indolin]-2'-one chemical structure, C12H14N2O, CAS 100510-66-5
6'-Aminospiro[cyclopentane-1,3'-indolin]-2'-one
CAS 100510-66-5C12H14N2O
6'-Fluorospiro[cyclopentane-1,3'-indolin]-2'-one chemical structure, C12H12FNO, CAS 52140-54-2
6'-Fluorospiro[cyclopentane-1,3'-indolin]-2'-one
CAS 52140-54-2C12H12FNO
4'-Methoxyspiro[cyclopentane-1,3'-indolin]-2'-one chemical structure, C13H15NO2, CAS 93831-00-6
4'-Methoxyspiro[cyclopentane-1,3'-indolin]-2'-one
CAS 93831-00-6C13H15NO2
5'-Aminospiro[cyclopentane-1,3'-indol]-2'(1'H)-one chemical structure, C12H14N2O, CAS 1267967-14-5
5'-Aminospiro[cyclopentane-1,3'-indol]-2'(1'H)-one
CAS 1267967-14-5C12H14N2O
(1S,2R)-1'-Methyl-2'-oxospiro[cyclopentane-2,3'-indole]-1-carbonitrile chemical structure, C14H14N2O, CAS 947184-92-1
(1S,2R)-1'-Methyl-2'-oxospiro[cyclopentane-2,3'-indole]-1-carbonitrile
CAS 947184-92-1C14H14N2O
1,1-Dimethyl-3-(2'-oxospiro[cyclopentane-1,3'-indolin]-5'-yl)urea chemical structure, C15H19N3O2, CAS 1329200-37-4
1,1-Dimethyl-3-(2'-oxospiro[cyclopentane-1,3'-indolin]-5'-yl)urea
CAS 1329200-37-4C15H19N3O2
1,1-Diethyl-3-(2'-oxospiro[cyclopentane-1,3'-indolin]-5'-yl)urea chemical structure, C17H23N3O2, CAS 1326731-70-7
1,1-Diethyl-3-(2'-oxospiro[cyclopentane-1,3'-indolin]-5'-yl)urea
CAS 1326731-70-7C17H23N3O2
1-(2'-Oxospiro[cyclopentane-1,3'-indolin]-5'-yl)-3-propylurea chemical structure, C16H21N3O2, CAS 1327102-49-7
1-(2'-Oxospiro[cyclopentane-1,3'-indolin]-5'-yl)-3-propylurea
CAS 1327102-49-7C16H21N3O2
5'-Hydroxyspiro[cyclopentane-1,3'-[3H]indol]-2'(1'H)-one chemical structure, C12H13NO2, CAS 2168024-62-0
5'-Hydroxyspiro[cyclopentane-1,3'-[3H]indol]-2'(1'H)-one
CAS 2168024-62-0C12H13NO2