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Murcko scaffold

Spiro(1,3-dioxolane-2,3'-(3H)indol)-2'(1'H)-one scaffold

39 chemicals on CompoundList share this ring system.

Rings
3
Scaffold atoms
14
Chemicals
39
With full pages
12
Scaffold SMILES

O=C1Nc2ccccc2C12OCCO2

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffoldOpen the Spiro(1,3-dioxolane-2,3'-(3H)indol)-2'(1'H)-one page
Murcko scaffold O=C1Nc2ccccc2C12OCCO2

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 1 to 39 of 39 chemicals

Spiro(1,3-dioxolane-2,3'-(3H)indol)-2'(1'H)-one chemical structure, C10H9NO3, CAS 6714-68-7
Spiro(1,3-dioxolane-2,3'-(3H)indol)-2'(1'H)-one
CAS 6714-68-7C10H9NO3
tert-Butyl 2'-oxospiro[1,3-dioxolane-2,3'-indole]-1'-carboxylate chemical structure, C15H17NO5, CAS 365222-72-6
tert-Butyl 2'-oxospiro[1,3-dioxolane-2,3'-indole]-1'-carboxylate
CAS 365222-72-6C15H17NO5
1'-(3,3-Dimethyl-2-oxobutyl)spiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one chemical structure, C16H19NO4, CAS 300588-82-3
1'-(3,3-Dimethyl-2-oxobutyl)spiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one
CAS 300588-82-3C16H19NO4
1'-Ethylspiro[1,3-dioxolane-2,3'-indole]-2'-one chemical structure, C12H13NO3, CAS 327986-55-0
1'-Ethylspiro[1,3-dioxolane-2,3'-indole]-2'-one
CAS 327986-55-0C12H13NO3
5'-Bromo-1'-(2-methylprop-2-enyl)spiro[1,3-dioxolane-2,3'-indole]-2'-one chemical structure, C14H14BrNO3, CAS 320369-54-8
5'-Bromo-1'-(2-methylprop-2-enyl)spiro[1,3-dioxolane-2,3'-indole]-2'-one
CAS 320369-54-8C14H14BrNO3
5'-Bromospiro[1,3-dioxolane-2,3'-[3H]indol]-2'(1'H)-one chemical structure, C10H8BrNO3, CAS 75822-54-7
5'-Bromospiro[1,3-dioxolane-2,3'-[3H]indol]-2'(1'H)-one
CAS 75822-54-7C10H8BrNO3
1'-Methyl-5'-nitrospiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one chemical structure, C11H10N2O5, CAS 330446-17-8
1'-Methyl-5'-nitrospiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one
CAS 330446-17-8C11H10N2O5
5'-Bromo-7'-methylspiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one chemical structure, C11H10BrNO3, CAS 330978-23-9
5'-Bromo-7'-methylspiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one
CAS 330978-23-9C11H10BrNO3
5'-Fluorospiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one chemical structure, C10H8FNO3, CAS 92532-92-8
5'-Fluorospiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one
CAS 92532-92-8C10H8FNO3
5'-Iodospiro[1,3-dioxolane-2,3'-1H-indole]-2'-one chemical structure, C10H8INO3, CAS 34058-27-0
5'-Iodospiro[1,3-dioxolane-2,3'-1H-indole]-2'-one
CAS 34058-27-0C10H8INO3
7'-Methyl-5'-nitrospiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one chemical structure, C11H10N2O5, CAS 330991-55-4
7'-Methyl-5'-nitrospiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one
CAS 330991-55-4C11H10N2O5
5'-Nitro-1',2'-dihydrospiro[1,3-dioxolane-2,3'-indole]-2'-one chemical structure, C10H8N2O5, CAS 75822-55-8
5'-Nitro-1',2'-dihydrospiro[1,3-dioxolane-2,3'-indole]-2'-one
CAS 75822-55-8C10H8N2O5
N-Hydroxy-2-(2'-oxospiro[1,3-dioxolane-2,3'-indole]-1'-yl)acetamide chemical structure, C12H12N2O5, CAS 340690-75-7
N-Hydroxy-2-(2'-oxospiro[1,3-dioxolane-2,3'-indole]-1'-yl)acetamide
CAS 340690-75-7C12H12N2O5
5'-Aminospiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one chemical structure, C10H10N2O3, CAS 113207-59-3
5'-Aminospiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one
CAS 113207-59-3C10H10N2O3
3-(1',3'-Dioxolynyl)-5-methyl-1,3-dihydro-2H-indol-2-one chemical structure, C11H11NO3, CAS 75822-58-1
3-(1',3'-Dioxolynyl)-5-methyl-1,3-dihydro-2H-indol-2-one
CAS 75822-58-1C11H11NO3
3-(4',5'-Dimethyl-1',3'-dioxolynyl)-1,3-dihydro-2H-indol-2-one chemical structure, C12H13NO3, CAS 63707-28-8
3-(4',5'-Dimethyl-1',3'-dioxolynyl)-1,3-dihydro-2H-indol-2-one
CAS 63707-28-8C12H13NO3
5'-Bromo-1'-(3,3-dimethyl-2-oxobutyl)spiro(1,3-dioxolane-2,3'-(3H)indol)-2'(1'H)-one chemical structure, C16H18BrNO4, CAS 314026-22-7
5'-Bromo-1'-(3,3-dimethyl-2-oxobutyl)spiro(1,3-dioxolane-2,3'-(3H)indol)-2'(1'H)-one
CAS 314026-22-7C16H18BrNO4
5'-Chlorospiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one chemical structure, C10H8ClNO3, CAS 75822-57-0
5'-Chlorospiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one
CAS 75822-57-0C10H8ClNO3
5',7'-Dimethylspiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one chemical structure, C12H13NO3, CAS 663946-78-9
5',7'-Dimethylspiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one
CAS 663946-78-9C12H13NO3
5'-Bromo-1'-propylspiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one chemical structure, C13H14BrNO3, CAS 352444-05-4
5'-Bromo-1'-propylspiro[1,3-dioxolane-2,3'-indol]-2'(1'H)-one
CAS 352444-05-4C13H14BrNO3
4',7'-Dimethyl-1'-prop-2-enylspiro[1,3-dioxolane-2,3'-indole]-2'-one chemical structure, C15H17NO3, CAS 883641-72-3
4',7'-Dimethyl-1'-prop-2-enylspiro[1,3-dioxolane-2,3'-indole]-2'-one
CAS 883641-72-3C15H17NO3
1',5',7'-Trimethylspiro[[1,3]dioxolane-2,3'-indolin]-2'-one chemical structure, C13H15NO3, CAS 883644-89-1
1',5',7'-Trimethylspiro[[1,3]dioxolane-2,3'-indolin]-2'-one
CAS 883644-89-1C13H15NO3
1'-Isopentyl-5',7'-dimethyl-1',2'-dihydrospiro([1,3]dioxolane-2,3'-indole)-2'-one chemical structure, C17H23NO3, CAS 883645-31-6
1'-Isopentyl-5',7'-dimethyl-1',2'-dihydrospiro([1,3]dioxolane-2,3'-indole)-2'-one
CAS 883645-31-6C17H23NO3
5',7'-Dimethyl-1'-prop-2-enylspiro[1,3-dioxolane-2,3'-indole]-2'-one chemical structure, C15H17NO3, CAS 883646-01-3
5',7'-Dimethyl-1'-prop-2-enylspiro[1,3-dioxolane-2,3'-indole]-2'-one
CAS 883646-01-3C15H17NO3