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Murcko scaffold

Ring system with 4 rings and 22 atoms

840 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
840
With full pages
15
Scaffold SMILES

O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 481 to 528 of 840 chemicals

2-Ethyl-2-{2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid chemical structure, C27H32N2O5, CAS 2171879-52-8
2-Ethyl-2-{2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid
CAS 2171879-52-8C27H32N2O5
4-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2,2-dimethylbutanoic acid chemical structure, C27H32N2O5, CAS 2172060-19-2
4-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2,2-dimethylbutanoic acid
CAS 2172060-19-2C27H32N2O5
3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(propan-2-yl)acetamido}propanoic acid chemical structure, C27H32N2O5, CAS 2172232-66-3
3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(propan-2-yl)acetamido}propanoic acid
CAS 2172232-66-3C27H32N2O5
(2R)-2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-methylpentanoic acid chemical structure, C27H32N2O5, CAS 2171282-36-1
(2R)-2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-methylpentanoic acid
CAS 2171282-36-1C27H32N2O5
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2-methylpropyl)acetamido}acetic acid chemical structure, C27H32N2O5, CAS 2171985-27-4
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2-methylpropyl)acetamido}acetic acid
CAS 2171985-27-4C27H32N2O5
2-({2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)-3-methylbutanoic acid chemical structure, C27H32N2O5, CAS 2172060-25-0
2-({2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)-3-methylbutanoic acid
CAS 2172060-25-0C27H32N2O5
4-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-methylpentanoic acid chemical structure, C27H32N2O5, CAS 2172579-15-4
4-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-methylpentanoic acid
CAS 2172579-15-4C27H32N2O5
3-{N-Ethyl-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid chemical structure, C27H32N2O5, CAS 2172232-78-7
3-{N-Ethyl-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid
CAS 2172232-78-7C27H32N2O5
2-{N-Ethyl-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpropanoic acid chemical structure, C27H32N2O5, CAS 2172060-36-3
2-{N-Ethyl-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpropanoic acid
CAS 2172060-36-3C27H32N2O5
2-[N-(Butan-2-yl)-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido]acetic acid chemical structure, C27H32N2O5, CAS 2171985-41-2
2-[N-(Butan-2-yl)-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido]acetic acid
CAS 2171985-41-2C27H32N2O5
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpentanoic acid chemical structure, C27H32N2O5, CAS 2172232-85-6
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpentanoic acid
CAS 2172232-85-6C27H32N2O5
2-{N-tert-Butyl-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}acetic acid chemical structure, C26H30N2O5, CAS 2172485-05-9
2-{N-tert-Butyl-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}acetic acid
CAS 2172485-05-9C26H30N2O5
3-{N-tert-Butyl-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}propanoic acid chemical structure, C28H34N2O5, CAS 2171881-01-7
3-{N-tert-Butyl-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}propanoic acid
CAS 2171881-01-7C28H34N2O5
3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4,4-dimethylpentanoic acid chemical structure, C28H34N2O5, CAS 2172035-80-0
3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4,4-dimethylpentanoic acid
CAS 2172035-80-0C28H34N2O5
2-({[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)butanoic acid chemical structure, C25H28N2O5, CAS 2171365-90-3
2-({[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)butanoic acid
CAS 2171365-90-3C25H28N2O5
5-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}pentanoic acid chemical structure, C25H28N2O5, CAS 2171149-66-7
5-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}pentanoic acid
CAS 2171149-66-7C25H28N2O5
2-({[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)-4,4-dimethylpentanoic acid chemical structure, C28H34N2O5, CAS 2171307-36-9
2-({[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)-4,4-dimethylpentanoic acid
CAS 2171307-36-9C28H34N2O5
6-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4,4-dimethylhexanoic acid chemical structure, C28H34N2O5, CAS 2171193-77-2
6-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4,4-dimethylhexanoic acid
CAS 2171193-77-2C28H34N2O5
6-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylheptanoic acid chemical structure, C28H34N2O5, CAS 2171375-18-9
6-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylheptanoic acid
CAS 2171375-18-9C28H34N2O5
(2S)-3-(tert-Butoxy)-2-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid chemical structure, C27H32N2O6, CAS 2171161-61-6
(2S)-3-(tert-Butoxy)-2-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid
CAS 2171161-61-6C27H32N2O6
6-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}hexanoic acid chemical structure, C26H30N2O5, CAS 2171149-83-8
6-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}hexanoic acid
CAS 2171149-83-8C26H30N2O5
2-({[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)-3-methylbutanoic acid chemical structure, C26H30N2O5, CAS 2171309-84-3
2-({[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)-3-methylbutanoic acid
CAS 2171309-84-3C26H30N2O5
3-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}-2-methylpropanoic acid chemical structure, C25H28N2O5, CAS 2171333-34-7
3-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}-2-methylpropanoic acid
CAS 2171333-34-7C25H28N2O5
3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2,2,3-trimethylbutanoic acid chemical structure, C27H32N2O5, CAS 2171171-81-4
3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2,2,3-trimethylbutanoic acid
CAS 2171171-81-4C27H32N2O5