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Murcko scaffold

Ring system with 4 rings and 22 atoms

840 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
840
With full pages
15
Scaffold SMILES

O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 577 to 624 of 840 chemicals

(2R)-2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-hydroxypropanoic acid chemical structure, C23H24N2O6, CAS 2171287-02-6
(2R)-2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-hydroxypropanoic acid
CAS 2171287-02-6C23H24N2O6
2-{N-[2-(Dimethylamino)ethyl]-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}acetic acid chemical structure, C26H31N3O5, CAS 2171202-79-0
2-{N-[2-(Dimethylamino)ethyl]-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}acetic acid
CAS 2171202-79-0C26H31N3O5
1-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}cyclobutane-1,3-dicarboxylic acid chemical structure, C21H19NO6, CAS 2171237-20-8
1-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}cyclobutane-1,3-dicarboxylic acid
CAS 2171237-20-8C21H19NO6
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-methoxypropanoic acid chemical structure, C24H26N2O6, CAS 2171226-89-2
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-methoxypropanoic acid
CAS 2171226-89-2C24H26N2O6
5-{N-Ethyl-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}pentanoic acid chemical structure, C28H34N2O5, CAS 2172599-81-2
5-{N-Ethyl-2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}pentanoic acid
CAS 2172599-81-2C28H34N2O5
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-formylcyclobutane-1-carboxylic acid chemical structure, C21H19NO5, CAS 2219374-70-4
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-formylcyclobutane-1-carboxylic acid
CAS 2219374-70-4C21H19NO5
2-({2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}oxy)acetic acid chemical structure, C23H24N2O6, CAS 2172567-76-7
2-({2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}oxy)acetic acid
CAS 2172567-76-7C23H24N2O6
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2,2-difluoropropanoic acid chemical structure, C24H24F2N2O5, CAS 2172585-14-5
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2,2-difluoropropanoic acid
CAS 2172585-14-5C24H24F2N2O5
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid chemical structure, C25H28N2O5, CAS 2171481-12-0
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid
CAS 2171481-12-0C25H28N2O5
2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]aceticacid,Mixtureofdiastereomers chemical structure, C21H21NO4, CAS 2408963-86-8
2-[2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]aceticacid,Mixtureofdiastereomers
CAS 2408963-86-8C21H21NO4
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-5-methylhex-4-enoic acid chemical structure, C28H32N2O5, CAS 2171729-73-8
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-5-methylhex-4-enoic acid
CAS 2171729-73-8C28H32N2O5
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(methoxycarbonyl)cyclobutane-1-carboxylic acid chemical structure, C22H21NO6, CAS 2219419-14-2
3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-(methoxycarbonyl)cyclobutane-1-carboxylic acid
CAS 2219419-14-2C22H21NO6
3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4,4,4-trifluorobutanoic acid chemical structure, C24H23F3N2O5, CAS 2171435-60-0
3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4,4,4-trifluorobutanoic acid
CAS 2171435-60-0C24H23F3N2O5
2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3,3,3-trifluoro-2-methylpropanoic acid chemical structure, C24H23F3N2O5, CAS 2171394-85-5
2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3,3,3-trifluoro-2-methylpropanoic acid
CAS 2171394-85-5C24H23F3N2O5
(2S,3R)-2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-hydroxybutanoic acid chemical structure, C25H28N2O6, CAS 2171251-41-3
(2S,3R)-2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-hydroxybutanoic acid
CAS 2171251-41-3C25H28N2O6
5-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpentanoic acid chemical structure, C27H32N2O5, CAS 2172294-87-8
5-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpentanoic acid
CAS 2172294-87-8C27H32N2O5
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4,4,4-trifluorobutanoic acid chemical structure, C25H25F3N2O5, CAS 2171786-99-3
2-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4,4,4-trifluorobutanoic acid
CAS 2171786-99-3C25H25F3N2O5
2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutyl]acetic acid chemical structure, C23H25NO4, CAS 2287322-88-5
2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutyl]acetic acid
CAS 2287322-88-5C23H25NO4
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}hex-4-ynoic acid chemical structure, C27H28N2O5, CAS 2171642-44-5
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}hex-4-ynoic acid
CAS 2171642-44-5C27H28N2O5
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}(2-hydroxyethyl)amino)cyclobutane-1-carboxylic acid chemical structure, C22H23NO5, CAS 2219379-47-0
1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}(2-hydroxyethyl)amino)cyclobutane-1-carboxylic acid
CAS 2219379-47-0C22H23NO5
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4,4,4-trifluorobutanoic acid chemical structure, C24H23F3N2O5, CAS 2171732-64-0
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4,4,4-trifluorobutanoic acid
CAS 2171732-64-0C24H23F3N2O5
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-5-methoxy-5-oxopentanoic acid chemical structure, C26H28N2O7, CAS 2171253-20-4
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-5-methoxy-5-oxopentanoic acid
CAS 2171253-20-4C26H28N2O7
(2S)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}propanoic acid chemical structure, C25H28N2O5, CAS 2171178-16-6
(2S)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}propanoic acid
CAS 2171178-16-6C25H28N2O5
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-(methoxymethyl)butanoic acid chemical structure, C26H30N2O6, CAS 2172442-67-8
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-(methoxymethyl)butanoic acid
CAS 2172442-67-8C26H30N2O6