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Murcko scaffold

Ring system with 4 rings and 22 atoms

840 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
840
With full pages
15
Scaffold SMILES

O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 385 to 432 of 840 chemicals

2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}-2-methylpropanoic acid chemical structure, C25H28N2O5, CAS 2172066-20-3
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}-2-methylpropanoic acid
CAS 2172066-20-3C25H28N2O5
(2R)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-hydroxypropanoic acid chemical structure, C24H26N2O6, CAS 2171197-17-2
(2R)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-hydroxypropanoic acid
CAS 2171197-17-2C24H26N2O6
2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}hex-4-ynoic acid chemical structure, C26H26N2O5, CAS 2171299-00-4
2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}hex-4-ynoic acid
CAS 2171299-00-4C26H26N2O5
3-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}-2-methylpropanoic acid chemical structure, C25H28N2O5, CAS 2171849-74-2
3-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}-2-methylpropanoic acid
CAS 2171849-74-2C25H28N2O5
4-{N-Ethyl-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid chemical structure, C27H32N2O5, CAS 2172000-44-9
4-{N-Ethyl-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid
CAS 2172000-44-9C27H32N2O5
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-methylhexanoic acid chemical structure, C28H34N2O5, CAS 2171710-11-3
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4-methylhexanoic acid
CAS 2171710-11-3C28H34N2O5
3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}heptanoic acid chemical structure, C28H34N2O5, CAS 2172154-61-7
3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}heptanoic acid
CAS 2172154-61-7C28H34N2O5
(2R)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-(methylsulfanyl)butanoic acid chemical structure, C25H28N2O5S, CAS 2171198-33-5
(2R)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-(methylsulfanyl)butanoic acid
CAS 2171198-33-5C25H28N2O5S
(3R)-3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}heptanoic acid chemical structure, C28H34N2O5, CAS 2171158-62-4
(3R)-3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}heptanoic acid
CAS 2171158-62-4C28H34N2O5
3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-(trifluoromethyl)propanoic acid chemical structure, C25H25F3N2O5, CAS 2171850-81-8
3-{2-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-(trifluoromethyl)propanoic acid
CAS 2171850-81-8C25H25F3N2O5
(3S)-3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}heptanoic acid chemical structure, C27H32N2O5, CAS 2171272-77-6
(3S)-3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}heptanoic acid
CAS 2171272-77-6C27H32N2O5
(3S)-3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}hexanoic acid chemical structure, C26H30N2O5, CAS 2171185-16-1
(3S)-3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}hexanoic acid
CAS 2171185-16-1C26H30N2O5
4-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}but-2-enoic acid chemical structure, C24H24N2O5, CAS 2172609-53-7
4-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}but-2-enoic acid
CAS 2172609-53-7C24H24N2O5
4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}pentanoic acid chemical structure, C26H30N2O5, CAS 2171998-01-7
4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}pentanoic acid
CAS 2171998-01-7C26H30N2O5
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylpentanoic acid chemical structure, C26H30N2O5, CAS 2171863-25-3
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylpentanoic acid
CAS 2171863-25-3C26H30N2O5
(2S,3R)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-hydroxybutanoic acid chemical structure, C24H26N2O6, CAS 2171199-66-7
(2S,3R)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-hydroxybutanoic acid
CAS 2171199-66-7C24H26N2O6
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}butanoic acid chemical structure, C25H28N2O5, CAS 2171676-09-6
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}butanoic acid
CAS 2171676-09-6C25H28N2O5
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3,3,3-trifluoropropanoic acid chemical structure, C24H23F3N2O5, CAS 2171712-69-7
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3,3,3-trifluoropropanoic acid
CAS 2171712-69-7C24H23F3N2O5
2-({[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}oxy)propanoic acid chemical structure, C23H24N2O6, CAS 2171359-62-7
2-({[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}oxy)propanoic acid
CAS 2171359-62-7C23H24N2O6
2-({[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}oxy)-3-methoxypropanoic acid chemical structure, C24H26N2O7, CAS 2171424-05-6
2-({[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}oxy)-3-methoxypropanoic acid
CAS 2171424-05-6C24H26N2O7
4-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}butanoic acid chemical structure, C25H28N2O5, CAS 2171169-96-1
4-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}butanoic acid
CAS 2171169-96-1C25H28N2O5
2-[N-(Butan-2-yl)-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido]acetic acid chemical structure, C26H30N2O5, CAS 2171356-53-7
2-[N-(Butan-2-yl)-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido]acetic acid
CAS 2171356-53-7C26H30N2O5
2-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2-methoxyethyl)formamido}acetic acid chemical structure, C25H28N2O6, CAS 2171155-59-0
2-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2-methoxyethyl)formamido}acetic acid
CAS 2171155-59-0C25H28N2O6
(2R)-2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid chemical structure, C23H24N2O5, CAS 2171206-10-1
(2R)-2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid
CAS 2171206-10-1C23H24N2O5