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Murcko scaffold

Ring system with 4 rings and 22 atoms

840 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
840
With full pages
15
Scaffold SMILES

O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 529 to 576 of 840 chemicals

3-(Dimethylamino)-2-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}propanoic acid chemical structure, C26H31N3O5, CAS 2171677-94-2
3-(Dimethylamino)-2-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}propanoic acid
CAS 2171677-94-2C26H31N3O5
4-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(propan-2-yl)formamido}butanoic acid chemical structure, C27H32N2O5, CAS 2171179-64-7
4-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(propan-2-yl)formamido}butanoic acid
CAS 2171179-64-7C27H32N2O5
3-{N-tert-Butyl-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid chemical structure, C27H32N2O5, CAS 2171196-57-7
3-{N-tert-Butyl-1-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid
CAS 2171196-57-7C27H32N2O5
(2S)-2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methylpentanoic acid chemical structure, C26H30N2O5, CAS 2171250-20-5
(2S)-2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methylpentanoic acid
CAS 2171250-20-5C26H30N2O5
(2S)-2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-methylbutanoic acid chemical structure, C25H28N2O5, CAS 2171161-44-5
(2S)-2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-methylbutanoic acid
CAS 2171161-44-5C25H28N2O5
2-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}butanoic acid chemical structure, C25H28N2O5, CAS 2171291-39-5
2-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}butanoic acid
CAS 2171291-39-5C25H28N2O5
(4S)-4-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-5,5,5-trifluoropentanoic acid chemical structure, C25H25F3N2O5, CAS 2171195-83-6
(4S)-4-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-5,5,5-trifluoropentanoic acid
CAS 2171195-83-6C25H25F3N2O5
2-[(2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}ethyl)sulfanyl]acetic acid chemical structure, C24H26N2O5S, CAS 2171145-05-2
2-[(2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}ethyl)sulfanyl]acetic acid
CAS 2171145-05-2C24H26N2O5S
2-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}-4,4-dimethylpentanoic acid chemical structure, C28H34N2O5, CAS 2171291-52-2
2-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylformamido}-4,4-dimethylpentanoic acid
CAS 2171291-52-2C28H34N2O5
4-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3,3-dimethylbutanoic acid chemical structure, C26H30N2O5, CAS 2171152-45-5
4-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3,3-dimethylbutanoic acid
CAS 2171152-45-5C26H30N2O5
4-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methoxybutanoic acid chemical structure, C25H28N2O6, CAS 2171331-87-4
4-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methoxybutanoic acid
CAS 2171331-87-4C25H28N2O6
3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4,4-dimethylpentanoic acid chemical structure, C27H32N2O5, CAS 2171430-30-9
3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4,4-dimethylpentanoic acid
CAS 2171430-30-9C27H32N2O5
4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3,3-dimethylbutanoic acid chemical structure, C27H32N2O5, CAS 2172108-03-9
4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3,3-dimethylbutanoic acid
CAS 2172108-03-9C27H32N2O5
2-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(prop-2-en-1-yl)formamido}acetic acid chemical structure, C25H26N2O5, CAS 2171230-58-1
2-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(prop-2-en-1-yl)formamido}acetic acid
CAS 2171230-58-1C25H26N2O5
2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}pent-4-enoic acid chemical structure, C25H26N2O5, CAS 2171292-19-4
2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}pent-4-enoic acid
CAS 2171292-19-4C25H26N2O5
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2-hydroxyethyl)acetamido}acetic acid chemical structure, C25H28N2O6, CAS 2172493-79-5
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2-hydroxyethyl)acetamido}acetic acid
CAS 2172493-79-5C25H28N2O6
3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid chemical structure, C23H24N2O5, CAS 2171139-93-6
3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid
CAS 2171139-93-6C23H24N2O5
(2S)-2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-(methylsulfanyl)butanoic acid chemical structure, C25H28N2O5S, CAS 2171280-33-2
(2S)-2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-(methylsulfanyl)butanoic acid
CAS 2171280-33-2C25H28N2O5S
(3S)-3-({[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)-5-methylhexanoic acid chemical structure, C28H34N2O5, CAS 2171289-78-2
(3S)-3-({[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)-5-methylhexanoic acid
CAS 2171289-78-2C28H34N2O5
2-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2-hydroxyethyl)formamido}acetic acid chemical structure, C24H26N2O6, CAS 2171175-43-0
2-{1-[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2-hydroxyethyl)formamido}acetic acid
CAS 2171175-43-0C24H26N2O6
(2R)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-methylbutanoic acid chemical structure, C25H28N2O5, CAS 2171244-38-3
(2R)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-methylbutanoic acid
CAS 2171244-38-3C25H28N2O5
2-(2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}ethoxy)acetic acid chemical structure, C24H26N2O6, CAS 2171246-22-1
2-(2-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}ethoxy)acetic acid
CAS 2171246-22-1C24H26N2O6
3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}pentanoic acid chemical structure, C25H28N2O5, CAS 2172264-57-0
3-{[3-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}pentanoic acid
CAS 2172264-57-0C25H28N2O5
2-[N-(2,2-Dimethylpropyl)-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido]acetic acid chemical structure, C28H34N2O5, CAS 2172168-80-6
2-[N-(2,2-Dimethylpropyl)-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido]acetic acid
CAS 2172168-80-6C28H34N2O5