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Murcko scaffold

Ring system with 4 rings and 22 atoms

840 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
840
With full pages
15
Scaffold SMILES

O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 193 to 240 of 840 chemicals

4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}hexanoic acid chemical structure, C27H32N2O5, CAS 2172191-81-8
4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}hexanoic acid
CAS 2172191-81-8C27H32N2O5
(2R)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3,3-dimethylbutanoic acid chemical structure, C27H32N2O5, CAS 2171228-67-2
(2R)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3,3-dimethylbutanoic acid
CAS 2171228-67-2C27H32N2O5
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-5-methoxypentanoic acid chemical structure, C26H30N2O6, CAS 2171636-63-6
2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-5-methoxypentanoic acid
CAS 2171636-63-6C26H30N2O6
4-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-hydroxybutanoic acid chemical structure, C24H26N2O6, CAS 2171865-17-9
4-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-hydroxybutanoic acid
CAS 2171865-17-9C24H26N2O6
(2R)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-hydroxybutanoic acid chemical structure, C24H26N2O6, CAS 2171167-66-9
(2R)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-hydroxybutanoic acid
CAS 2171167-66-9C24H26N2O6
2-[(2-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}ethyl)sulfanyl]acetic acid chemical structure, C25H28N2O5S, CAS 2171929-93-2
2-[(2-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}ethyl)sulfanyl]acetic acid
CAS 2171929-93-2C25H28N2O5S
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}hexanoic acid chemical structure, C27H32N2O5, CAS 2171866-34-3
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}hexanoic acid
CAS 2171866-34-3C27H32N2O5
(2S)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-methylbutanoic acid chemical structure, C26H30N2O5, CAS 2171220-82-7
(2S)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-methylbutanoic acid
CAS 2171220-82-7C26H30N2O5
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid chemical structure, C25H28N2O5, CAS 2172387-71-0
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid
CAS 2172387-71-0C25H28N2O5
2-({[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)butanoic acid chemical structure, C25H28N2O5, CAS 2172196-55-1
2-({[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)butanoic acid
CAS 2172196-55-1C25H28N2O5
4-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-methylbutanoic acid chemical structure, C25H28N2O5, CAS 2172120-72-6
4-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-methylbutanoic acid
CAS 2172120-72-6C25H28N2O5
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2,2,3-trimethylbutanoic acid chemical structure, C27H32N2O5, CAS 2171804-46-7
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2,2,3-trimethylbutanoic acid
CAS 2171804-46-7C27H32N2O5
2-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)-3-methylbutanoic acid chemical structure, C27H32N2O5, CAS 2172121-22-9
2-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)-3-methylbutanoic acid
CAS 2172121-22-9C27H32N2O5
(2S)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}propanoic acid chemical structure, C24H26N2O5, CAS 2171175-01-0
(2S)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}propanoic acid
CAS 2171175-01-0C24H26N2O5
(2S,3S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-methylpentanoic acid chemical structure, C26H30N2O5, CAS 2171141-44-7
(2S,3S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3-methylpentanoic acid
CAS 2171141-44-7C26H30N2O5
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2,2-difluoropropanoic acid chemical structure, C23H22F2N2O5, CAS 2172508-05-1
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2,2-difluoropropanoic acid
CAS 2172508-05-1C23H22F2N2O5
2-{N-[2-(Dimethylamino)ethyl]-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}acetic acid chemical structure, C27H33N3O5, CAS 2172195-46-7
2-{N-[2-(Dimethylamino)ethyl]-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}acetic acid
CAS 2172195-46-7C27H33N3O5
2-Ethyl-2-({[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)butanoic acid chemical structure, C27H32N2O5, CAS 2172396-68-6
2-Ethyl-2-({[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}methyl)butanoic acid
CAS 2172396-68-6C27H32N2O5
2-{N-Ethyl-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpropanoic acid chemical structure, C27H32N2O5, CAS 2172316-49-1
2-{N-Ethyl-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpropanoic acid
CAS 2172316-49-1C27H32N2O5
2-Ethyl-2-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid chemical structure, C27H32N2O5, CAS 2172108-65-3
2-Ethyl-2-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}butanoic acid
CAS 2172108-65-3C27H32N2O5
(2S)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3,3-dimethylbutanoic acid chemical structure, C27H32N2O5, CAS 2171172-44-2
(2S)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3,3-dimethylbutanoic acid
CAS 2171172-44-2C27H32N2O5
6-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methylhexanoic acid chemical structure, C27H32N2O5, CAS 2172061-80-0
6-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-4-methylhexanoic acid
CAS 2172061-80-0C27H32N2O5
(2R)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}pentanoic acid chemical structure, C26H30N2O5, CAS 2171172-49-7
(2R)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}pentanoic acid
CAS 2171172-49-7C26H30N2O5
4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(propan-2-yl)acetamido}butanoic acid chemical structure, C28H34N2O5, CAS 2172110-02-8
4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(propan-2-yl)acetamido}butanoic acid
CAS 2172110-02-8C28H34N2O5