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Murcko scaffold

Ring system with 4 rings and 22 atoms

840 chemicals on CompoundList share this ring system.

Rings
4
Scaffold atoms
22
Chemicals
840
With full pages
15
Scaffold SMILES

O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

A Bemis-Murcko scaffold is what remains of a molecule when every side chain is removed: the rings and the chains that link them. Chemicals that share a scaffold often belong to the same compound series, which helps when you look for analogues, alternative suppliers or related building blocks.

Substructure search with this scaffold
Murcko scaffold O=C(NC1CCC1)OCC1c2ccccc2-c2ccccc21

Computed from the structures of the chemicals listed here. Stereo and charges are removed before the scaffold is taken.

Chemicals with this scaffold

Open one to see its structure, properties and suppliers.

Showing 289 to 336 of 840 chemicals

2-[N-(Butan-2-yl)-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido]acetic acid chemical structure, C27H32N2O5, CAS 2171988-44-4
2-[N-(Butan-2-yl)-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido]acetic acid
CAS 2171988-44-4C27H32N2O5
5-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylpentanoic acid chemical structure, C26H30N2O5, CAS 2172376-46-2
5-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylpentanoic acid
CAS 2172376-46-2C26H30N2O5
5-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}pentanoic acid chemical structure, C25H28N2O5, CAS 2171796-06-6
5-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}pentanoic acid
CAS 2171796-06-6C25H28N2O5
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2,2-dimethylpropanoic acid chemical structure, C25H28N2O5, CAS 2172207-71-3
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2,2-dimethylpropanoic acid
CAS 2172207-71-3C25H28N2O5
2-{[3-Ethoxy-1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutyl]formamido}acetic acid chemical structure, C26H30N2O6, CAS 2171655-80-2
2-{[3-Ethoxy-1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2,2-dimethylcyclobutyl]formamido}acetic acid
CAS 2171655-80-2C26H30N2O6
6-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylheptanoic acid chemical structure, C28H34N2O5, CAS 2171798-30-2
6-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methylheptanoic acid
CAS 2171798-30-2C28H34N2O5
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylbutanoic acid chemical structure, C26H30N2O5, CAS 2171912-81-3
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylbutanoic acid
CAS 2171912-81-3C26H30N2O5
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methoxypropanoic acid chemical structure, C24H26N2O6, CAS 2172149-78-7
3-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-2-methoxypropanoic acid
CAS 2172149-78-7C24H26N2O6
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4,4,4-trifluorobutanoic acid chemical structure, C25H25F3N2O5, CAS 2171653-85-1
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-4,4,4-trifluorobutanoic acid
CAS 2171653-85-1C25H25F3N2O5
(2S,3R)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-hydroxybutanoic acid chemical structure, C25H28N2O6, CAS 2171232-26-9
(2S,3R)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-hydroxybutanoic acid
CAS 2171232-26-9C25H28N2O6
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}butanoic acid chemical structure, C26H30N2O5, CAS 2171687-71-9
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}butanoic acid
CAS 2171687-71-9C26H30N2O5
2-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)butanoic acid chemical structure, C26H30N2O5, CAS 2172118-81-7
2-({2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}methyl)butanoic acid
CAS 2172118-81-7C26H30N2O5
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2-hydroxyethyl)formamido}acetic acid chemical structure, C24H26N2O6, CAS 2172185-99-6
2-{1-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(2-hydroxyethyl)formamido}acetic acid
CAS 2172185-99-6C24H26N2O6
4-Ethyl-6-{[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}hexanoic acid chemical structure, C28H34N2O5, CAS 2171815-04-4
4-Ethyl-6-{[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}hexanoic acid
CAS 2171815-04-4C28H34N2O5
(2R)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-methylbutanoic acid chemical structure, C26H30N2O5, CAS 2171212-56-7
(2R)-2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-methylbutanoic acid
CAS 2171212-56-7C26H30N2O5
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(prop-2-en-1-yl)acetamido}acetic acid chemical structure, C26H28N2O5, CAS 2171814-00-7
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-(prop-2-en-1-yl)acetamido}acetic acid
CAS 2171814-00-7C26H28N2O5
2-(2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}ethoxy)acetic acid chemical structure, C25H28N2O6, CAS 2172187-47-0
2-(2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}ethoxy)acetic acid
CAS 2172187-47-0C25H28N2O6
4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}butanoic acid chemical structure, C26H30N2O5, CAS 2171916-82-6
4-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]-N-methylacetamido}butanoic acid
CAS 2171916-82-6C26H30N2O5
3-{N-Ethyl-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}butanoic acid chemical structure, C26H30N2O5, CAS 2172441-12-0
3-{N-Ethyl-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}butanoic acid
CAS 2172441-12-0C26H30N2O5
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3,3-dimethylbutanoic acid chemical structure, C26H30N2O5, CAS 2171178-23-5
(2S)-2-{[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}-3,3-dimethylbutanoic acid
CAS 2171178-23-5C26H30N2O5
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3,3-dimethylbutanoic acid chemical structure, C27H32N2O5, CAS 2171599-49-6
2-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3,3-dimethylbutanoic acid
CAS 2171599-49-6C27H32N2O5
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-methylbutanoic acid chemical structure, C26H30N2O5, CAS 2171817-30-2
3-{2-[1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-3-methylbutanoic acid
CAS 2171817-30-2C26H30N2O5
3-{N-Ethyl-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid chemical structure, C25H28N2O5, CAS 2172144-59-9
3-{N-Ethyl-1-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]formamido}propanoic acid
CAS 2172144-59-9C25H28N2O5
3-{N-Ethyl-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpropanoic acid chemical structure, C27H32N2O5, CAS 2172190-54-2
3-{N-Ethyl-2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclobutyl]acetamido}-2-methylpropanoic acid
CAS 2172190-54-2C27H32N2O5